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Salivary cotinine concentrations in daily smokers in Barcelona, Spain: a cross-sectional study.

Fu M, Fernandez E, Martínez-Sánchez JM, Pascual JA, Schiaffino A, Agudo A, Ariza C, Borràs JM, Samet JM, DCOT Study investigato - BMC Public Health (2009)

Bottom Line: The inclusion of a quadratic component for number of cigarettes smoked in the regression analyses resulted in an improvement of the fit (R2 = 0.386; p < 0.05).Cotinine concentration differed significantly by sex, with men having higher levels.This study shows that salivary cotinine concentration is significantly associated with the number of cigarettes smoked and sex, but not with other smoking-related variables.

View Article: PubMed Central - HTML - PubMed

Affiliation: Tobacco Control & Research Unit, Institut Català d'Oncologia (ICO-IDIBELL), Av. Gran Via de L'Hospitalet 199-203, 08907 L'Hospitalet de Llobregat (Barcelona), Spain. mfu@iconcologia.net

ABSTRACT

Background: Characterizing and comparing the determinant of cotinine concentrations in different populations should facilitate a better understanding of smoking patterns and addiction. This study describes and characterizes determinants of salivary cotinine concentration in a sample of Spanish adult daily smoker men and women.

Methods: A cross-sectional study was carried out between March 2004 and December 2005 in a representative sample of 1245 people from the general population of Barcelona, Spain. A standard questionnaire was used to gather information on active tobacco smoking and passive exposure, and a saliva specimen was obtained to determine salivary cotinine concentration. Two hundred and eleven adult smokers (>16 years old) with complete data were included in the analysis. Determinants of cotinine concentrations were assessed using linear regression models.

Results: Salivary cotinine concentration was associated with the reported number of cigarettes smoked in the previous 24 hours (R2 = 0.339; p < 0.05). The inclusion of a quadratic component for number of cigarettes smoked in the regression analyses resulted in an improvement of the fit (R2 = 0.386; p < 0.05). Cotinine concentration differed significantly by sex, with men having higher levels.

Conclusion: This study shows that salivary cotinine concentration is significantly associated with the number of cigarettes smoked and sex, but not with other smoking-related variables.

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Related in: MedlinePlus

The distribution of salivary cotinine concentration in relation to the number of cigarettes smoked during the 24 hours prior to saliva collection.
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Figure 1: The distribution of salivary cotinine concentration in relation to the number of cigarettes smoked during the 24 hours prior to saliva collection.

Mentions: The distribution of salivary cotinine concentration in relation to the number of cigarettes smoked during the 24 hours prior to saliva collection is shown in Fig 1. In the simple unadjusted linear model the number of cigarettes smoked in the last 24 hours was a predictor of cotinine concentrations (R2 = 0.339; solid line). A significant improvement of the fit was obtained with a quadratic model, in which the number of cigarettes smoked accounted for almost 39% (adjusted R2) of the variance, and the exposure-response relationship leveled-off near 20 cigarettes (Fig. 1; dashed line). [see Additional file 1]


Salivary cotinine concentrations in daily smokers in Barcelona, Spain: a cross-sectional study.

Fu M, Fernandez E, Martínez-Sánchez JM, Pascual JA, Schiaffino A, Agudo A, Ariza C, Borràs JM, Samet JM, DCOT Study investigato - BMC Public Health (2009)

The distribution of salivary cotinine concentration in relation to the number of cigarettes smoked during the 24 hours prior to saliva collection.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2749042&req=5

Figure 1: The distribution of salivary cotinine concentration in relation to the number of cigarettes smoked during the 24 hours prior to saliva collection.
Mentions: The distribution of salivary cotinine concentration in relation to the number of cigarettes smoked during the 24 hours prior to saliva collection is shown in Fig 1. In the simple unadjusted linear model the number of cigarettes smoked in the last 24 hours was a predictor of cotinine concentrations (R2 = 0.339; solid line). A significant improvement of the fit was obtained with a quadratic model, in which the number of cigarettes smoked accounted for almost 39% (adjusted R2) of the variance, and the exposure-response relationship leveled-off near 20 cigarettes (Fig. 1; dashed line). [see Additional file 1]

Bottom Line: The inclusion of a quadratic component for number of cigarettes smoked in the regression analyses resulted in an improvement of the fit (R2 = 0.386; p < 0.05).Cotinine concentration differed significantly by sex, with men having higher levels.This study shows that salivary cotinine concentration is significantly associated with the number of cigarettes smoked and sex, but not with other smoking-related variables.

View Article: PubMed Central - HTML - PubMed

Affiliation: Tobacco Control & Research Unit, Institut Català d'Oncologia (ICO-IDIBELL), Av. Gran Via de L'Hospitalet 199-203, 08907 L'Hospitalet de Llobregat (Barcelona), Spain. mfu@iconcologia.net

ABSTRACT

Background: Characterizing and comparing the determinant of cotinine concentrations in different populations should facilitate a better understanding of smoking patterns and addiction. This study describes and characterizes determinants of salivary cotinine concentration in a sample of Spanish adult daily smoker men and women.

Methods: A cross-sectional study was carried out between March 2004 and December 2005 in a representative sample of 1245 people from the general population of Barcelona, Spain. A standard questionnaire was used to gather information on active tobacco smoking and passive exposure, and a saliva specimen was obtained to determine salivary cotinine concentration. Two hundred and eleven adult smokers (>16 years old) with complete data were included in the analysis. Determinants of cotinine concentrations were assessed using linear regression models.

Results: Salivary cotinine concentration was associated with the reported number of cigarettes smoked in the previous 24 hours (R2 = 0.339; p < 0.05). The inclusion of a quadratic component for number of cigarettes smoked in the regression analyses resulted in an improvement of the fit (R2 = 0.386; p < 0.05). Cotinine concentration differed significantly by sex, with men having higher levels.

Conclusion: This study shows that salivary cotinine concentration is significantly associated with the number of cigarettes smoked and sex, but not with other smoking-related variables.

Show MeSH
Related in: MedlinePlus