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Dual-tasking and gait in people with mild cognitive impairment. The effect of working memory.

Montero-Odasso M, Bergman H, Phillips NA, Wong CH, Sourial N, Chertkow H - BMC Geriatr (2009)

Bottom Line: After adjustments, working memory was the only cognitive factor which remained significantly associated with a slow GV.In older adults with MCI, low working memory performance was associated with slow GV.Our findings suggest that cortical control of gait is associated with decline in working memory in people with MCI.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medicine, Division of Geriatric Medicine, Parkwood Hospital, The University of Western Ontario, London, ON Canada. Manuel.MonteroOdasso@sjhc.london.on.ca

ABSTRACT

Background: Cognition and mobility in older adults are closely associated and they decline together with aging. Studies evaluating associations between cognitive factors and gait performance in people with Mild Cognitive Impairment (MCI) are scarce. In this study, our aim was to determine whether specific cognitive factors have a more identifiable effect on gait velocity during dual-tasking in people with MCI.

Methods: Fifty-five participants, mean age 77.7 (SD = 5.9), 45% women, with MCI were evaluated for global cognition, working memory, executive function, and attention. Gait Velocity (GV) was measured under a single-task condition (single GV) and under two dual-task conditions: 1) while counting backwards (counting GV), 2) while naming animals (verbal GV). Multivariable linear regression analysis was used to examine associations with an alpha-level of 0.05.

Results: Participants experienced a reduction in GV while engaging in dual-task challenges (p < 0.005). Low executive function and working memory performances were associated with slow single GV (p = 0.038), slow counting GV (p = 0.017), and slow verbal GV (p = 0.031). After adjustments, working memory was the only cognitive factor which remained significantly associated with a slow GV.

Conclusion: In older adults with MCI, low working memory performance was associated with slow GV. Dual-task conditions showed the strongest associations with gait slowing. Our findings suggest that cortical control of gait is associated with decline in working memory in people with MCI.

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Related in: MedlinePlus

Mean gait velocity under single (sGV) and dual tasks (vGV, cGV). Note: sGV: single task gait velocity; vGV: verbal gait velocity; cGV: counting gait velocity.
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Figure 2: Mean gait velocity under single (sGV) and dual tasks (vGV, cGV). Note: sGV: single task gait velocity; vGV: verbal gait velocity; cGV: counting gait velocity.

Mentions: Participants experienced a significant decrease in gait velocity while engaging dual-task conditions when compared with single GV (p < 0.0001, Figure 2). A significant correlation between GV under both types of dual-task (verbal GV = 0.65 m/s, SD = 0.2, and counting GV = 0.63 m/s, SD = 0.2, r = 0.89) was found. The associations between GVs under dual-tasks and the cognitive functions explored on the multivariable analysis were analogous, as presented in Additional file 1.


Dual-tasking and gait in people with mild cognitive impairment. The effect of working memory.

Montero-Odasso M, Bergman H, Phillips NA, Wong CH, Sourial N, Chertkow H - BMC Geriatr (2009)

Mean gait velocity under single (sGV) and dual tasks (vGV, cGV). Note: sGV: single task gait velocity; vGV: verbal gait velocity; cGV: counting gait velocity.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2748075&req=5

Figure 2: Mean gait velocity under single (sGV) and dual tasks (vGV, cGV). Note: sGV: single task gait velocity; vGV: verbal gait velocity; cGV: counting gait velocity.
Mentions: Participants experienced a significant decrease in gait velocity while engaging dual-task conditions when compared with single GV (p < 0.0001, Figure 2). A significant correlation between GV under both types of dual-task (verbal GV = 0.65 m/s, SD = 0.2, and counting GV = 0.63 m/s, SD = 0.2, r = 0.89) was found. The associations between GVs under dual-tasks and the cognitive functions explored on the multivariable analysis were analogous, as presented in Additional file 1.

Bottom Line: After adjustments, working memory was the only cognitive factor which remained significantly associated with a slow GV.In older adults with MCI, low working memory performance was associated with slow GV.Our findings suggest that cortical control of gait is associated with decline in working memory in people with MCI.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medicine, Division of Geriatric Medicine, Parkwood Hospital, The University of Western Ontario, London, ON Canada. Manuel.MonteroOdasso@sjhc.london.on.ca

ABSTRACT

Background: Cognition and mobility in older adults are closely associated and they decline together with aging. Studies evaluating associations between cognitive factors and gait performance in people with Mild Cognitive Impairment (MCI) are scarce. In this study, our aim was to determine whether specific cognitive factors have a more identifiable effect on gait velocity during dual-tasking in people with MCI.

Methods: Fifty-five participants, mean age 77.7 (SD = 5.9), 45% women, with MCI were evaluated for global cognition, working memory, executive function, and attention. Gait Velocity (GV) was measured under a single-task condition (single GV) and under two dual-task conditions: 1) while counting backwards (counting GV), 2) while naming animals (verbal GV). Multivariable linear regression analysis was used to examine associations with an alpha-level of 0.05.

Results: Participants experienced a reduction in GV while engaging in dual-task challenges (p < 0.005). Low executive function and working memory performances were associated with slow single GV (p = 0.038), slow counting GV (p = 0.017), and slow verbal GV (p = 0.031). After adjustments, working memory was the only cognitive factor which remained significantly associated with a slow GV.

Conclusion: In older adults with MCI, low working memory performance was associated with slow GV. Dual-task conditions showed the strongest associations with gait slowing. Our findings suggest that cortical control of gait is associated with decline in working memory in people with MCI.

Show MeSH
Related in: MedlinePlus