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Dual-tasking and gait in people with mild cognitive impairment. The effect of working memory.

Montero-Odasso M, Bergman H, Phillips NA, Wong CH, Sourial N, Chertkow H - BMC Geriatr (2009)

Bottom Line: After adjustments, working memory was the only cognitive factor which remained significantly associated with a slow GV.In older adults with MCI, low working memory performance was associated with slow GV.Our findings suggest that cortical control of gait is associated with decline in working memory in people with MCI.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medicine, Division of Geriatric Medicine, Parkwood Hospital, The University of Western Ontario, London, ON Canada. Manuel.MonteroOdasso@sjhc.london.on.ca

ABSTRACT

Background: Cognition and mobility in older adults are closely associated and they decline together with aging. Studies evaluating associations between cognitive factors and gait performance in people with Mild Cognitive Impairment (MCI) are scarce. In this study, our aim was to determine whether specific cognitive factors have a more identifiable effect on gait velocity during dual-tasking in people with MCI.

Methods: Fifty-five participants, mean age 77.7 (SD = 5.9), 45% women, with MCI were evaluated for global cognition, working memory, executive function, and attention. Gait Velocity (GV) was measured under a single-task condition (single GV) and under two dual-task conditions: 1) while counting backwards (counting GV), 2) while naming animals (verbal GV). Multivariable linear regression analysis was used to examine associations with an alpha-level of 0.05.

Results: Participants experienced a reduction in GV while engaging in dual-task challenges (p < 0.005). Low executive function and working memory performances were associated with slow single GV (p = 0.038), slow counting GV (p = 0.017), and slow verbal GV (p = 0.031). After adjustments, working memory was the only cognitive factor which remained significantly associated with a slow GV.

Conclusion: In older adults with MCI, low working memory performance was associated with slow GV. Dual-task conditions showed the strongest associations with gait slowing. Our findings suggest that cortical control of gait is associated with decline in working memory in people with MCI.

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Related in: MedlinePlus

Selection of study participants. Note: MCI: mild cognitive impairment; GV: gait velocity; sGV: single task gait velocity; OA: osteoarthritis.
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Figure 1: Selection of study participants. Note: MCI: mild cognitive impairment; GV: gait velocity; sGV: single task gait velocity; OA: osteoarthritis.

Mentions: Sixty subjects with MCI were contacted and all agreed to participate in the study. Five individuals were excluded due to comorbidities that affected the gait performance. The assembly of the cohort is schematized in Figure 1 and divided in groups according to their gait velocity (GV) for descriptive purposes, based on cut-offs determined in previous studies[9,39,44]. Of study participants, 47.25% had a normal GV (> 1 m/s), 45.45% an intermediate GV (between 1 and 0.7 m/s) and 7.27% a slow GV (< 0.7 m/s)


Dual-tasking and gait in people with mild cognitive impairment. The effect of working memory.

Montero-Odasso M, Bergman H, Phillips NA, Wong CH, Sourial N, Chertkow H - BMC Geriatr (2009)

Selection of study participants. Note: MCI: mild cognitive impairment; GV: gait velocity; sGV: single task gait velocity; OA: osteoarthritis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2748075&req=5

Figure 1: Selection of study participants. Note: MCI: mild cognitive impairment; GV: gait velocity; sGV: single task gait velocity; OA: osteoarthritis.
Mentions: Sixty subjects with MCI were contacted and all agreed to participate in the study. Five individuals were excluded due to comorbidities that affected the gait performance. The assembly of the cohort is schematized in Figure 1 and divided in groups according to their gait velocity (GV) for descriptive purposes, based on cut-offs determined in previous studies[9,39,44]. Of study participants, 47.25% had a normal GV (> 1 m/s), 45.45% an intermediate GV (between 1 and 0.7 m/s) and 7.27% a slow GV (< 0.7 m/s)

Bottom Line: After adjustments, working memory was the only cognitive factor which remained significantly associated with a slow GV.In older adults with MCI, low working memory performance was associated with slow GV.Our findings suggest that cortical control of gait is associated with decline in working memory in people with MCI.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Medicine, Division of Geriatric Medicine, Parkwood Hospital, The University of Western Ontario, London, ON Canada. Manuel.MonteroOdasso@sjhc.london.on.ca

ABSTRACT

Background: Cognition and mobility in older adults are closely associated and they decline together with aging. Studies evaluating associations between cognitive factors and gait performance in people with Mild Cognitive Impairment (MCI) are scarce. In this study, our aim was to determine whether specific cognitive factors have a more identifiable effect on gait velocity during dual-tasking in people with MCI.

Methods: Fifty-five participants, mean age 77.7 (SD = 5.9), 45% women, with MCI were evaluated for global cognition, working memory, executive function, and attention. Gait Velocity (GV) was measured under a single-task condition (single GV) and under two dual-task conditions: 1) while counting backwards (counting GV), 2) while naming animals (verbal GV). Multivariable linear regression analysis was used to examine associations with an alpha-level of 0.05.

Results: Participants experienced a reduction in GV while engaging in dual-task challenges (p < 0.005). Low executive function and working memory performances were associated with slow single GV (p = 0.038), slow counting GV (p = 0.017), and slow verbal GV (p = 0.031). After adjustments, working memory was the only cognitive factor which remained significantly associated with a slow GV.

Conclusion: In older adults with MCI, low working memory performance was associated with slow GV. Dual-task conditions showed the strongest associations with gait slowing. Our findings suggest that cortical control of gait is associated with decline in working memory in people with MCI.

Show MeSH
Related in: MedlinePlus