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RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer.

Church RD, Yu J, Fleshman JW, Shannon WD, Govindan R, McLeod HL - Br. J. Cancer (2004)

Bottom Line: Cyclooxygenases (particularily Cox-2) are involved in carcinogenesis and metastatic cancer progression.The expression profiles of the cyclooxygenases and the roles they play in established tumours of similar stage remains unclear.We report that Cox-1 and Cox-2 expression is highly variable in Dukes' C tumours, and changes in Cox-1 expression may be of importance.

View Article: PubMed Central - PubMed

Affiliation: 1Department of Surgery, Washington University School of Medicine, St Louis, MO 63110-1093, USA.

ABSTRACT
Cyclooxygenases (particularily Cox-2) are involved in carcinogenesis and metastatic cancer progression. The expression profiles of the cyclooxygenases and the roles they play in established tumours of similar stage remains unclear. We report that Cox-1 and Cox-2 expression is highly variable in Dukes' C tumours, and changes in Cox-1 expression may be of importance.

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Related in: MedlinePlus

Comparison of variations in expression of Cox 1 (A) and Cox 2 (B) paired normal mucosa and tumour tissue samples. Horizontal lines represent the mean for each population.
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fig1: Comparison of variations in expression of Cox 1 (A) and Cox 2 (B) paired normal mucosa and tumour tissue samples. Horizontal lines represent the mean for each population.

Mentions: Substantial variation in the expression of Cyclooxygenase 2 mRNA was observed in normal mucosa (33-fold) and tumour tissues (51-fold). Variable Cox-1 expression was also seen in normal mucosa (68-fold) and tumour (40-fold). Cox-2 was significantly upregulated in the tumour samples compared to paired mucosal tissues (median tumour : normal ratio=1.54, range 0.20–8.96, P=0.012, Figure 1BFigure 1


RNA profiling of cyclooxygenases 1 and 2 in colorectal cancer.

Church RD, Yu J, Fleshman JW, Shannon WD, Govindan R, McLeod HL - Br. J. Cancer (2004)

Comparison of variations in expression of Cox 1 (A) and Cox 2 (B) paired normal mucosa and tumour tissue samples. Horizontal lines represent the mean for each population.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2747709&req=5

fig1: Comparison of variations in expression of Cox 1 (A) and Cox 2 (B) paired normal mucosa and tumour tissue samples. Horizontal lines represent the mean for each population.
Mentions: Substantial variation in the expression of Cyclooxygenase 2 mRNA was observed in normal mucosa (33-fold) and tumour tissues (51-fold). Variable Cox-1 expression was also seen in normal mucosa (68-fold) and tumour (40-fold). Cox-2 was significantly upregulated in the tumour samples compared to paired mucosal tissues (median tumour : normal ratio=1.54, range 0.20–8.96, P=0.012, Figure 1BFigure 1

Bottom Line: Cyclooxygenases (particularily Cox-2) are involved in carcinogenesis and metastatic cancer progression.The expression profiles of the cyclooxygenases and the roles they play in established tumours of similar stage remains unclear.We report that Cox-1 and Cox-2 expression is highly variable in Dukes' C tumours, and changes in Cox-1 expression may be of importance.

View Article: PubMed Central - PubMed

Affiliation: 1Department of Surgery, Washington University School of Medicine, St Louis, MO 63110-1093, USA.

ABSTRACT
Cyclooxygenases (particularily Cox-2) are involved in carcinogenesis and metastatic cancer progression. The expression profiles of the cyclooxygenases and the roles they play in established tumours of similar stage remains unclear. We report that Cox-1 and Cox-2 expression is highly variable in Dukes' C tumours, and changes in Cox-1 expression may be of importance.

Show MeSH
Related in: MedlinePlus