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Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.

Broutet N, Plebani M, Sakarovitch C, Sipponen P, Mégraud F, Eurohepygast Study Gro - Br. J. Cancer (2003)

Bottom Line: For ACG patients, the areas under the PGA, PGC, PGA/PGC, and gastrin ROC curves were 0.55, 0.62, 0.73, and 0.58, respectively.The best cut-off point for PGA/PGC was 5.6, with sensitivity 65% and specificity 77.9%.The best cut-off point for PGA/PGC was 4.7, with sensitivity 77.1% and specificity 87.4%.

View Article: PubMed Central - PubMed

Affiliation: Unité d'Epidémiologie des Maladies Digestives, Université Victor Segalen Bordeaux, Cedex, France.

ABSTRACT
Serum levels of pepsinogen and gastrin are parameters that can be used as biomarkers for gastric mucosa. The aim of this study was to validate these serum biomarkers, that is pepsinogen A (PGA), pepsinogen C (PGC), PGA/PGC ratio, and gastrin, as screening tests for precancerous lesions: atrophic chronic gastritis (ACG) or Helicobacter pylori-related corpus-predominant or multifocal atrophy. The study population was comprised of a subsample of 284 patients from the 451 included in the Eurohepygast cohort, between 1995 and 1997. The concentrations of PGA, PGC, and gastrin were measured by radioimmunoassays. Histological diagnosis was the gold standard. Cut-off points were calculated using receiving operator characteristics (ROC) curves. Factors linked to variation of biomarkers were identified using multivariate linear regression. The mean of each biomarker in the sample was: PGA, 77.4 microg x l(-1); PGC, 13.2 microg x l(-1); PGA/PGC, 6.7; and gastrin, 62.4 ng x l(-1). For ACG patients, the areas under the PGA, PGC, PGA/PGC, and gastrin ROC curves were 0.55, 0.62, 0.73, and 0.58, respectively. The best cut-off point for PGA/PGC was 5.6, with sensitivity 65% and specificity 77.9%. For H. pylori-related corpus-predominant or multifocal atrophy, the areas under the respective ROC curves were 0.57, 0.67, 0.84, and 0.69. The best cut-off point for PGA/PGC was 4.7, with sensitivity 77.1% and specificity 87.4%. The results suggested that only the PGA/PGC ratio can be considered as a biomarker for precancerous lesions of the stomach, and may be useful as a screening test.

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Mean PGA/PGC ratio according to age group and gender (interaction), in dyspeptic patients. Results of the Eurohepygast study.
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fig6: Mean PGA/PGC ratio according to age group and gender (interaction), in dyspeptic patients. Results of the Eurohepygast study.

Mentions: A multivariable linear regression considering the PGA/PGC ratio as the outcome, was performed using all 34 variables available in the database. In the final linear model performed on the sample, few variables remained associated with a variation of PGA/PGC: presence of ACG, and presence of H. pylori and CagA antibodies. In this model, an interaction between age and gender was found, demonstrating a different age effect on the variation of PGA/PGC according to gender (Figure 6Figure 6


Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.

Broutet N, Plebani M, Sakarovitch C, Sipponen P, Mégraud F, Eurohepygast Study Gro - Br. J. Cancer (2003)

Mean PGA/PGC ratio according to age group and gender (interaction), in dyspeptic patients. Results of the Eurohepygast study.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2747577&req=5

fig6: Mean PGA/PGC ratio according to age group and gender (interaction), in dyspeptic patients. Results of the Eurohepygast study.
Mentions: A multivariable linear regression considering the PGA/PGC ratio as the outcome, was performed using all 34 variables available in the database. In the final linear model performed on the sample, few variables remained associated with a variation of PGA/PGC: presence of ACG, and presence of H. pylori and CagA antibodies. In this model, an interaction between age and gender was found, demonstrating a different age effect on the variation of PGA/PGC according to gender (Figure 6Figure 6

Bottom Line: For ACG patients, the areas under the PGA, PGC, PGA/PGC, and gastrin ROC curves were 0.55, 0.62, 0.73, and 0.58, respectively.The best cut-off point for PGA/PGC was 5.6, with sensitivity 65% and specificity 77.9%.The best cut-off point for PGA/PGC was 4.7, with sensitivity 77.1% and specificity 87.4%.

View Article: PubMed Central - PubMed

Affiliation: Unité d'Epidémiologie des Maladies Digestives, Université Victor Segalen Bordeaux, Cedex, France.

ABSTRACT
Serum levels of pepsinogen and gastrin are parameters that can be used as biomarkers for gastric mucosa. The aim of this study was to validate these serum biomarkers, that is pepsinogen A (PGA), pepsinogen C (PGC), PGA/PGC ratio, and gastrin, as screening tests for precancerous lesions: atrophic chronic gastritis (ACG) or Helicobacter pylori-related corpus-predominant or multifocal atrophy. The study population was comprised of a subsample of 284 patients from the 451 included in the Eurohepygast cohort, between 1995 and 1997. The concentrations of PGA, PGC, and gastrin were measured by radioimmunoassays. Histological diagnosis was the gold standard. Cut-off points were calculated using receiving operator characteristics (ROC) curves. Factors linked to variation of biomarkers were identified using multivariate linear regression. The mean of each biomarker in the sample was: PGA, 77.4 microg x l(-1); PGC, 13.2 microg x l(-1); PGA/PGC, 6.7; and gastrin, 62.4 ng x l(-1). For ACG patients, the areas under the PGA, PGC, PGA/PGC, and gastrin ROC curves were 0.55, 0.62, 0.73, and 0.58, respectively. The best cut-off point for PGA/PGC was 5.6, with sensitivity 65% and specificity 77.9%. For H. pylori-related corpus-predominant or multifocal atrophy, the areas under the respective ROC curves were 0.57, 0.67, 0.84, and 0.69. The best cut-off point for PGA/PGC was 4.7, with sensitivity 77.1% and specificity 87.4%. The results suggested that only the PGA/PGC ratio can be considered as a biomarker for precancerous lesions of the stomach, and may be useful as a screening test.

Show MeSH
Related in: MedlinePlus