Limits...
Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.

Broutet N, Plebani M, Sakarovitch C, Sipponen P, Mégraud F, Eurohepygast Study Gro - Br. J. Cancer (2003)

Bottom Line: For ACG patients, the areas under the PGA, PGC, PGA/PGC, and gastrin ROC curves were 0.55, 0.62, 0.73, and 0.58, respectively.The best cut-off point for PGA/PGC was 5.6, with sensitivity 65% and specificity 77.9%.The best cut-off point for PGA/PGC was 4.7, with sensitivity 77.1% and specificity 87.4%.

View Article: PubMed Central - PubMed

Affiliation: Unité d'Epidémiologie des Maladies Digestives, Université Victor Segalen Bordeaux, Cedex, France.

ABSTRACT
Serum levels of pepsinogen and gastrin are parameters that can be used as biomarkers for gastric mucosa. The aim of this study was to validate these serum biomarkers, that is pepsinogen A (PGA), pepsinogen C (PGC), PGA/PGC ratio, and gastrin, as screening tests for precancerous lesions: atrophic chronic gastritis (ACG) or Helicobacter pylori-related corpus-predominant or multifocal atrophy. The study population was comprised of a subsample of 284 patients from the 451 included in the Eurohepygast cohort, between 1995 and 1997. The concentrations of PGA, PGC, and gastrin were measured by radioimmunoassays. Histological diagnosis was the gold standard. Cut-off points were calculated using receiving operator characteristics (ROC) curves. Factors linked to variation of biomarkers were identified using multivariate linear regression. The mean of each biomarker in the sample was: PGA, 77.4 microg x l(-1); PGC, 13.2 microg x l(-1); PGA/PGC, 6.7; and gastrin, 62.4 ng x l(-1). For ACG patients, the areas under the PGA, PGC, PGA/PGC, and gastrin ROC curves were 0.55, 0.62, 0.73, and 0.58, respectively. The best cut-off point for PGA/PGC was 5.6, with sensitivity 65% and specificity 77.9%. For H. pylori-related corpus-predominant or multifocal atrophy, the areas under the respective ROC curves were 0.57, 0.67, 0.84, and 0.69. The best cut-off point for PGA/PGC was 4.7, with sensitivity 77.1% and specificity 87.4%. The results suggested that only the PGA/PGC ratio can be considered as a biomarker for precancerous lesions of the stomach, and may be useful as a screening test.

Show MeSH

Related in: MedlinePlus

Patients included in the Eurohepygast study and reasons for exclusion of the present study.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2747577&req=5

fig1: Patients included in the Eurohepygast study and reasons for exclusion of the present study.

Mentions: This cross-sectional study was based on data from the Eurohepygast cohort collected between 1995 and 1997 at the inclusion of patients. A total of 451 patients were enrolled from 14 different European countries. To be included, patients with dyspepsia had to present themselves at one of the 19 participating European centres, to be between 18 and 75 years of age, and to have received no previous H. pylori eradication treatment nor proton pump inhibitors. Endoscopy with biopsies was performed. A questionnaire was filled out by the clinician and a blood sample was taken from nonfasting patients. Only a subsample of 284 patients was included in this study (Figure 1Figure 1


Pepsinogen A, pepsinogen C, and gastrin as markers of atrophic chronic gastritis in European dyspeptics.

Broutet N, Plebani M, Sakarovitch C, Sipponen P, Mégraud F, Eurohepygast Study Gro - Br. J. Cancer (2003)

Patients included in the Eurohepygast study and reasons for exclusion of the present study.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2747577&req=5

fig1: Patients included in the Eurohepygast study and reasons for exclusion of the present study.
Mentions: This cross-sectional study was based on data from the Eurohepygast cohort collected between 1995 and 1997 at the inclusion of patients. A total of 451 patients were enrolled from 14 different European countries. To be included, patients with dyspepsia had to present themselves at one of the 19 participating European centres, to be between 18 and 75 years of age, and to have received no previous H. pylori eradication treatment nor proton pump inhibitors. Endoscopy with biopsies was performed. A questionnaire was filled out by the clinician and a blood sample was taken from nonfasting patients. Only a subsample of 284 patients was included in this study (Figure 1Figure 1

Bottom Line: For ACG patients, the areas under the PGA, PGC, PGA/PGC, and gastrin ROC curves were 0.55, 0.62, 0.73, and 0.58, respectively.The best cut-off point for PGA/PGC was 5.6, with sensitivity 65% and specificity 77.9%.The best cut-off point for PGA/PGC was 4.7, with sensitivity 77.1% and specificity 87.4%.

View Article: PubMed Central - PubMed

Affiliation: Unité d'Epidémiologie des Maladies Digestives, Université Victor Segalen Bordeaux, Cedex, France.

ABSTRACT
Serum levels of pepsinogen and gastrin are parameters that can be used as biomarkers for gastric mucosa. The aim of this study was to validate these serum biomarkers, that is pepsinogen A (PGA), pepsinogen C (PGC), PGA/PGC ratio, and gastrin, as screening tests for precancerous lesions: atrophic chronic gastritis (ACG) or Helicobacter pylori-related corpus-predominant or multifocal atrophy. The study population was comprised of a subsample of 284 patients from the 451 included in the Eurohepygast cohort, between 1995 and 1997. The concentrations of PGA, PGC, and gastrin were measured by radioimmunoassays. Histological diagnosis was the gold standard. Cut-off points were calculated using receiving operator characteristics (ROC) curves. Factors linked to variation of biomarkers were identified using multivariate linear regression. The mean of each biomarker in the sample was: PGA, 77.4 microg x l(-1); PGC, 13.2 microg x l(-1); PGA/PGC, 6.7; and gastrin, 62.4 ng x l(-1). For ACG patients, the areas under the PGA, PGC, PGA/PGC, and gastrin ROC curves were 0.55, 0.62, 0.73, and 0.58, respectively. The best cut-off point for PGA/PGC was 5.6, with sensitivity 65% and specificity 77.9%. For H. pylori-related corpus-predominant or multifocal atrophy, the areas under the respective ROC curves were 0.57, 0.67, 0.84, and 0.69. The best cut-off point for PGA/PGC was 4.7, with sensitivity 77.1% and specificity 87.4%. The results suggested that only the PGA/PGC ratio can be considered as a biomarker for precancerous lesions of the stomach, and may be useful as a screening test.

Show MeSH
Related in: MedlinePlus