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Construct validation of the Health Utilities Index and the Child Health Questionnaire in children undergoing cancer chemotherapy.

Sung L, Greenberg ML, Doyle JJ, Young NL, Ingber S, Rubenstein J, Wong J, Samanta T, McLimont M, Feldman BM - Br. J. Cancer (2003)

Bottom Line: HUI and CHQ summary scores were compared to visual analogue scale (VAS) scores.The HUI questionnaires required less time to complete (mean=3.1, s.d.=1 min) compared with CHQ (mean=13.1, s.d.=3.4 min, P<0.0001).The Health Utilities Index is subject to a ceiling effect whereas CHQ requires more time to complete.

View Article: PubMed Central - PubMed

Affiliation: Department of Health Policy Management and Evaluation, University of Toronto, Ontario, Canada. Lillian.sung@sickkids.ca

ABSTRACT
The objective of this study was to evaluate the construct validity of two questionnaire-based measures of health-related quality of life (HRQL) in children undergoing cancer chemotherapy: the Health Utilities Index (HUI) and the Child Health Questionnaire (CHQ). Subjects were children hospitalised for chemotherapy. To examine construct validity: (1). a priori expected relations between CHQ concepts and HUI attributes were examined; (2). HUI and CHQ summary scores were compared to visual analogue scale (VAS) scores. Ease of completion was rated using a 5-point categorical scale and completion time was recorded. A total of 36 subjects were included. The maximum score was seen in 15 (47%) of HUI3 assessments. As predicted, CHQ body pain was moderately correlated with HUI3 pain (r=0.51), CHQ physical functioning was moderately correlated with HUI2 mobility (r=0.58) and CHQ mental health was moderately correlated with HUI2 emotion (r=0.53). Only the CHQ psychosocial subscale (and not HUI) was correlated with VAS (r=0.44). The CHQ and the HUI were both easy to use. The HUI questionnaires required less time to complete (mean=3.1, s.d.=1 min) compared with CHQ (mean=13.1, s.d.=3.4 min, P<0.0001). In conclusion, HUI and CHQ demonstrated construct validity in children undergoing cancer chemotherapy. The Health Utilities Index is subject to a ceiling effect whereas CHQ requires more time to complete.

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Related in: MedlinePlus

Scatterplot of CHQ PsS and VAS. The y-axis represents the scores on the CHQ PsS in which higher scores reflect better HRQL. The x-axis represents the scores on the global HRQL VAS in which 0 is equal to death and 1 is equal to perfect health. The line represents the least-squares regression line.
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fig2: Scatterplot of CHQ PsS and VAS. The y-axis represents the scores on the CHQ PsS in which higher scores reflect better HRQL. The x-axis represents the scores on the global HRQL VAS in which 0 is equal to death and 1 is equal to perfect health. The line represents the least-squares regression line.

Mentions: Scatterplot of HUI2 and VAS. The y-axis represents the scores on the HUI2 where 0 represents HRQL equal to death and 1 represents HRQL equal to perfect health. The x-axis represents the scores on the global HRQL VAS with the same anchors.


Construct validation of the Health Utilities Index and the Child Health Questionnaire in children undergoing cancer chemotherapy.

Sung L, Greenberg ML, Doyle JJ, Young NL, Ingber S, Rubenstein J, Wong J, Samanta T, McLimont M, Feldman BM - Br. J. Cancer (2003)

Scatterplot of CHQ PsS and VAS. The y-axis represents the scores on the CHQ PsS in which higher scores reflect better HRQL. The x-axis represents the scores on the global HRQL VAS in which 0 is equal to death and 1 is equal to perfect health. The line represents the least-squares regression line.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2747569&req=5

fig2: Scatterplot of CHQ PsS and VAS. The y-axis represents the scores on the CHQ PsS in which higher scores reflect better HRQL. The x-axis represents the scores on the global HRQL VAS in which 0 is equal to death and 1 is equal to perfect health. The line represents the least-squares regression line.
Mentions: Scatterplot of HUI2 and VAS. The y-axis represents the scores on the HUI2 where 0 represents HRQL equal to death and 1 represents HRQL equal to perfect health. The x-axis represents the scores on the global HRQL VAS with the same anchors.

Bottom Line: HUI and CHQ summary scores were compared to visual analogue scale (VAS) scores.The HUI questionnaires required less time to complete (mean=3.1, s.d.=1 min) compared with CHQ (mean=13.1, s.d.=3.4 min, P<0.0001).The Health Utilities Index is subject to a ceiling effect whereas CHQ requires more time to complete.

View Article: PubMed Central - PubMed

Affiliation: Department of Health Policy Management and Evaluation, University of Toronto, Ontario, Canada. Lillian.sung@sickkids.ca

ABSTRACT
The objective of this study was to evaluate the construct validity of two questionnaire-based measures of health-related quality of life (HRQL) in children undergoing cancer chemotherapy: the Health Utilities Index (HUI) and the Child Health Questionnaire (CHQ). Subjects were children hospitalised for chemotherapy. To examine construct validity: (1). a priori expected relations between CHQ concepts and HUI attributes were examined; (2). HUI and CHQ summary scores were compared to visual analogue scale (VAS) scores. Ease of completion was rated using a 5-point categorical scale and completion time was recorded. A total of 36 subjects were included. The maximum score was seen in 15 (47%) of HUI3 assessments. As predicted, CHQ body pain was moderately correlated with HUI3 pain (r=0.51), CHQ physical functioning was moderately correlated with HUI2 mobility (r=0.58) and CHQ mental health was moderately correlated with HUI2 emotion (r=0.53). Only the CHQ psychosocial subscale (and not HUI) was correlated with VAS (r=0.44). The CHQ and the HUI were both easy to use. The HUI questionnaires required less time to complete (mean=3.1, s.d.=1 min) compared with CHQ (mean=13.1, s.d.=3.4 min, P<0.0001). In conclusion, HUI and CHQ demonstrated construct validity in children undergoing cancer chemotherapy. The Health Utilities Index is subject to a ceiling effect whereas CHQ requires more time to complete.

Show MeSH
Related in: MedlinePlus