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Surveillance for endometrial cancer with transvaginal ultrasonography of breast cancer patients under tamoxifen treatment.

Ciatto S, Cecchini S, Gervasi G, Landini A, Zappa M, Crocetti E - Br. J. Cancer (2003)

Bottom Line: Raising this threshold increased specificity with a substantial loss of sensitivity (>or=3, >or=4, >or=6, >or=9 mm; spec.=25.8, 44.5, 76.1, 91.5%, sens.=100, 91.6, 75.0, 66.6%).The presence of AUB was rather specific (88.94%) but poorly sensitive (41.67%).A combination of AUB presence/absence and thickness allowed the best accuracy (AUB + thickness >or=3, >or=4 or >or=5; sens.=100, 81.6 or 91.6%; spec.=22.8, 40.4, or 56.7%).

View Article: PubMed Central - PubMed

Affiliation: Centro per lo Studio e la Prevenzione Oncologica, Firenze, Italy. s.ciatto@cspo.it

ABSTRACT
The association of endometrial thickness with the risk of developing endometrial cancer (EC) within 2 years was investigated in a consecutive cohort of 1205 breast cancer patients under tamoxifen treatment, undergoing transvaginal ultrasonography (TVUS) for follow-up purpose (asymptomatic, 1068) or for abnormal uterine bleeding (AUB, 137). Linkage with tumour registry allowed for the follow-up of 3184.3 person-years. According to underlying incidence, 1.85 EC cases were expected in the study cohort while 12 were observed (observed/expected ratio=6.49, 95% CI 3.35-11.33; asymptomatic=4.09, 95% CI 1.65-8.43, symptomatic=35.71, 95% CI 11.59-83.34). No EC was observed with thickness (half layer) <3 mm. Raising this threshold increased specificity with a substantial loss of sensitivity (>or=3, >or=4, >or=6, >or=9 mm; spec.=25.8, 44.5, 76.1, 91.5%, sens.=100, 91.6, 75.0, 66.6%). The presence of AUB was rather specific (88.94%) but poorly sensitive (41.67%). A combination of AUB presence/absence and thickness allowed the best accuracy (AUB + thickness >or=3, >or=4 or >or=5; sens.=100, 81.6 or 91.6%; spec.=22.8, 40.4, or 56.7%). Breast cancer patients under tamoxifen might be selected for further invasive assessment on the basis of AUB and endometrial thickness assessed at TVUS.

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Related in: MedlinePlus

ROC curve of sensitivity and specificity for EC based on different cutoff levels (1–20 mm) of endometrial thickness (half thickness).
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Related In: Results  -  Collection


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fig1: ROC curve of sensitivity and specificity for EC based on different cutoff levels (1–20 mm) of endometrial thickness (half thickness).

Mentions: Number of EC delayed diagnoses and of unnecessary assessments , sensitivity, specificity and predictive values (PV) for different cutoffs of endometrial thickness (half layer) and for different protocols prompting immediate invasive diagnostic assessment for EC


Surveillance for endometrial cancer with transvaginal ultrasonography of breast cancer patients under tamoxifen treatment.

Ciatto S, Cecchini S, Gervasi G, Landini A, Zappa M, Crocetti E - Br. J. Cancer (2003)

ROC curve of sensitivity and specificity for EC based on different cutoff levels (1–20 mm) of endometrial thickness (half thickness).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2747558&req=5

fig1: ROC curve of sensitivity and specificity for EC based on different cutoff levels (1–20 mm) of endometrial thickness (half thickness).
Mentions: Number of EC delayed diagnoses and of unnecessary assessments , sensitivity, specificity and predictive values (PV) for different cutoffs of endometrial thickness (half layer) and for different protocols prompting immediate invasive diagnostic assessment for EC

Bottom Line: Raising this threshold increased specificity with a substantial loss of sensitivity (>or=3, >or=4, >or=6, >or=9 mm; spec.=25.8, 44.5, 76.1, 91.5%, sens.=100, 91.6, 75.0, 66.6%).The presence of AUB was rather specific (88.94%) but poorly sensitive (41.67%).A combination of AUB presence/absence and thickness allowed the best accuracy (AUB + thickness >or=3, >or=4 or >or=5; sens.=100, 81.6 or 91.6%; spec.=22.8, 40.4, or 56.7%).

View Article: PubMed Central - PubMed

Affiliation: Centro per lo Studio e la Prevenzione Oncologica, Firenze, Italy. s.ciatto@cspo.it

ABSTRACT
The association of endometrial thickness with the risk of developing endometrial cancer (EC) within 2 years was investigated in a consecutive cohort of 1205 breast cancer patients under tamoxifen treatment, undergoing transvaginal ultrasonography (TVUS) for follow-up purpose (asymptomatic, 1068) or for abnormal uterine bleeding (AUB, 137). Linkage with tumour registry allowed for the follow-up of 3184.3 person-years. According to underlying incidence, 1.85 EC cases were expected in the study cohort while 12 were observed (observed/expected ratio=6.49, 95% CI 3.35-11.33; asymptomatic=4.09, 95% CI 1.65-8.43, symptomatic=35.71, 95% CI 11.59-83.34). No EC was observed with thickness (half layer) <3 mm. Raising this threshold increased specificity with a substantial loss of sensitivity (>or=3, >or=4, >or=6, >or=9 mm; spec.=25.8, 44.5, 76.1, 91.5%, sens.=100, 91.6, 75.0, 66.6%). The presence of AUB was rather specific (88.94%) but poorly sensitive (41.67%). A combination of AUB presence/absence and thickness allowed the best accuracy (AUB + thickness >or=3, >or=4 or >or=5; sens.=100, 81.6 or 91.6%; spec.=22.8, 40.4, or 56.7%). Breast cancer patients under tamoxifen might be selected for further invasive assessment on the basis of AUB and endometrial thickness assessed at TVUS.

Show MeSH
Related in: MedlinePlus