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Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma.

Ueno T, Linder S, Elmberger G - Br. J. Cancer (2003)

Bottom Line: Napsin A is an aspartic proteinase expressed in lung and kidney.We have reported that napsin A is expressed in type II pneumocytes and in adenocarcinomas of the lung.The expression of napsin was examined in 118 lung tissues including 16 metastases by in situ hybridisation.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute and Hospital, Stockholm, Sweden.

ABSTRACT
Napsin A is an aspartic proteinase expressed in lung and kidney. We have reported that napsin A is expressed in type II pneumocytes and in adenocarcinomas of the lung. The expression of napsin was examined in 118 lung tissues including 16 metastases by in situ hybridisation. Napsin was expressed in the tumour cell compartment in 33 of 39 adenocarcinomas (84.6%), in two of 11 large cell carcinomas and in one lung metastasis of a renal cell carcinoma. Expression of napsin was found to be associated with a high degree of differentiation in adenocarcinoma. Immunohistochemistry was performed for three proteins currently used as markers for lung adenocarcinoma : surfactant protein-A, surfactant protein-B and thyroid transcription factor-1. Thyroid transcription factor-1 showed the same sensitivity (84.6%) as napsin for adenocarcinoma, whereas surfactant protein-A and surfactant protein-B showed lower sensitivities. Among these markers, napsin showed the highest specificity (94.3%) for adenocarcinoma in nonsmall cell lung carcinoma. We conclude that napsin is a promising marker for the diagnosis of primary lung adenocarcinoma.

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Expression of each marker in relation to differentiation grade of lung adenocarcinoma. Napsin showed an association with the differentiation grade of adenocarcinoma. A similar association was observed for Sp-A.
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fig3: Expression of each marker in relation to differentiation grade of lung adenocarcinoma. Napsin showed an association with the differentiation grade of adenocarcinoma. A similar association was observed for Sp-A.

Mentions: The association between the expression of each marker and differentiation grade of the adenocarcinoma is presented in Figure 3Figure 3


Aspartic proteinase napsin is a useful marker for diagnosis of primary lung adenocarcinoma.

Ueno T, Linder S, Elmberger G - Br. J. Cancer (2003)

Expression of each marker in relation to differentiation grade of lung adenocarcinoma. Napsin showed an association with the differentiation grade of adenocarcinoma. A similar association was observed for Sp-A.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2747556&req=5

fig3: Expression of each marker in relation to differentiation grade of lung adenocarcinoma. Napsin showed an association with the differentiation grade of adenocarcinoma. A similar association was observed for Sp-A.
Mentions: The association between the expression of each marker and differentiation grade of the adenocarcinoma is presented in Figure 3Figure 3

Bottom Line: Napsin A is an aspartic proteinase expressed in lung and kidney.We have reported that napsin A is expressed in type II pneumocytes and in adenocarcinomas of the lung.The expression of napsin was examined in 118 lung tissues including 16 metastases by in situ hybridisation.

View Article: PubMed Central - PubMed

Affiliation: Department of Oncology-Pathology, Cancer Center Karolinska, Karolinska Institute and Hospital, Stockholm, Sweden.

ABSTRACT
Napsin A is an aspartic proteinase expressed in lung and kidney. We have reported that napsin A is expressed in type II pneumocytes and in adenocarcinomas of the lung. The expression of napsin was examined in 118 lung tissues including 16 metastases by in situ hybridisation. Napsin was expressed in the tumour cell compartment in 33 of 39 adenocarcinomas (84.6%), in two of 11 large cell carcinomas and in one lung metastasis of a renal cell carcinoma. Expression of napsin was found to be associated with a high degree of differentiation in adenocarcinoma. Immunohistochemistry was performed for three proteins currently used as markers for lung adenocarcinoma : surfactant protein-A, surfactant protein-B and thyroid transcription factor-1. Thyroid transcription factor-1 showed the same sensitivity (84.6%) as napsin for adenocarcinoma, whereas surfactant protein-A and surfactant protein-B showed lower sensitivities. Among these markers, napsin showed the highest specificity (94.3%) for adenocarcinoma in nonsmall cell lung carcinoma. We conclude that napsin is a promising marker for the diagnosis of primary lung adenocarcinoma.

Show MeSH
Related in: MedlinePlus