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Prognostic value of Goseki histological classification in adenocarcinoma of the cardia.

Fontana MG, La Pinta M, Moneghini D, Villanacci V, Donato F, Rindi G, Paparini S, Baronchelli C, Bertoli G, Alquati P - Br. J. Cancer (2003)

Bottom Line: Various histologic classification systems have been proposed as prognostic factors for gastric cancer.Multivariate analysis showed that the only lymph node positivity was a significant predictor of survival: 7.2% of patients with, but 41.5% of those without nodal involvement were alive after five years (P=0.0001).In conclusion, we found no prognostic role for Goseki or the traditional histological indexes, while the TNM staging system and particularly lymph node positivity were the main predictors of survival in patients with cardia adenocarcinoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, University of Brescisa and Spedali Civili, P. le Spedali Civili, Italy. nnxspa@tin.it

ABSTRACT
Various histologic classification systems have been proposed as prognostic factors for gastric cancer. We assessed the prognostic value of Goseki classification as well as the TNM staging system, histological tumour grading, Lauren, WHO, Goseki and Siewert classifications in 100 patients with cardia carcinoma undergoing curative surgery. Two patients were lost at follow-up. The median time of follow-up in the remaining patients was 32.9 months after surgery (range: 0.1-142.1 months). No differences in survival rates were observed according to tumour grading, Lauren or WHO histologic or Siewert topographical classification. No differences were found according to Goseki classes, when considering either the mucin content of the carcinoma (types I and III vs II and IV) or the differentiation grade (types I and II vs III and IV). Multivariate analysis showed that the only lymph node positivity was a significant predictor of survival: 7.2% of patients with, but 41.5% of those without nodal involvement were alive after five years (P=0.0001). In conclusion, we found no prognostic role for Goseki or the traditional histological indexes, while the TNM staging system and particularly lymph node positivity were the main predictors of survival in patients with cardia adenocarcinoma.

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Related in: MedlinePlus

Survival curves according to Goseki classes.
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fig4: Survival curves according to Goseki classes.

Mentions: No differences in survival were observed for the different Goseki classes (Figure 4Figure 4


Prognostic value of Goseki histological classification in adenocarcinoma of the cardia.

Fontana MG, La Pinta M, Moneghini D, Villanacci V, Donato F, Rindi G, Paparini S, Baronchelli C, Bertoli G, Alquati P - Br. J. Cancer (2003)

Survival curves according to Goseki classes.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2747543&req=5

fig4: Survival curves according to Goseki classes.
Mentions: No differences in survival were observed for the different Goseki classes (Figure 4Figure 4

Bottom Line: Various histologic classification systems have been proposed as prognostic factors for gastric cancer.Multivariate analysis showed that the only lymph node positivity was a significant predictor of survival: 7.2% of patients with, but 41.5% of those without nodal involvement were alive after five years (P=0.0001).In conclusion, we found no prognostic role for Goseki or the traditional histological indexes, while the TNM staging system and particularly lymph node positivity were the main predictors of survival in patients with cardia adenocarcinoma.

View Article: PubMed Central - PubMed

Affiliation: Department of Surgery, University of Brescisa and Spedali Civili, P. le Spedali Civili, Italy. nnxspa@tin.it

ABSTRACT
Various histologic classification systems have been proposed as prognostic factors for gastric cancer. We assessed the prognostic value of Goseki classification as well as the TNM staging system, histological tumour grading, Lauren, WHO, Goseki and Siewert classifications in 100 patients with cardia carcinoma undergoing curative surgery. Two patients were lost at follow-up. The median time of follow-up in the remaining patients was 32.9 months after surgery (range: 0.1-142.1 months). No differences in survival rates were observed according to tumour grading, Lauren or WHO histologic or Siewert topographical classification. No differences were found according to Goseki classes, when considering either the mucin content of the carcinoma (types I and III vs II and IV) or the differentiation grade (types I and II vs III and IV). Multivariate analysis showed that the only lymph node positivity was a significant predictor of survival: 7.2% of patients with, but 41.5% of those without nodal involvement were alive after five years (P=0.0001). In conclusion, we found no prognostic role for Goseki or the traditional histological indexes, while the TNM staging system and particularly lymph node positivity were the main predictors of survival in patients with cardia adenocarcinoma.

Show MeSH
Related in: MedlinePlus