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CT perfusion in acute stroke.

Khandelwal N - Indian J Radiol Imaging (2008)

Bottom Line: Stroke is a heterogeneous syndrome caused by multiple mechanisms, all of which result in disruption of normal cerebral blood flow and thereby cause cerebral dysfunction.Delay in diagnosis and treatment translates into increase neuronal loss and thereby increased morbidity.This article is an endeavor to explain the pathophysiology of cerebral ischemia and the role of CT perfusion in detecting it.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiodiagnosis and Imaging, PGIMER, Sector 12, Chandigarh, India.

ABSTRACT
Stroke is a heterogeneous syndrome caused by multiple mechanisms, all of which result in disruption of normal cerebral blood flow and thereby cause cerebral dysfunction. Its early diagnosis is important as its treatment is dependent on the time elapsed since ictus. Delay in diagnosis and treatment translates into increase neuronal loss and thereby increased morbidity. CT scan, and in particular perfusion CT, has helped greatly in the early diagnosis of stroke. This article is an endeavor to explain the pathophysiology of cerebral ischemia and the role of CT perfusion in detecting it.

No MeSH data available.


Related in: MedlinePlus

Color-coded maps and time–attenuation curve (bottom right panel) from the umbra (arrow) showing significant reduction in the flow as compared with the normal side (block arrow)
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Figure 0007: Color-coded maps and time–attenuation curve (bottom right panel) from the umbra (arrow) showing significant reduction in the flow as compared with the normal side (block arrow)

Mentions: MTT, CBV, and CBF values from multiple areas under consideration on the affected as well as the normal hemisphere are obtained first. Then the MTT values are evaluated. If the MTT is raised as compared to the normal side, ischemia/infarction is present. Next, to differentiate ischemic and infarcted tissues, CBF and CBV values are compared. If CBF is reduced and CBV is normal or slightly reduced, the tissue ischemia is likely to be reversible [Figure 6]; if CBF and CBV are markedly reduced or if TTP is not measurable, the tissue may be infarcted [Figure 7].


CT perfusion in acute stroke.

Khandelwal N - Indian J Radiol Imaging (2008)

Color-coded maps and time–attenuation curve (bottom right panel) from the umbra (arrow) showing significant reduction in the flow as compared with the normal side (block arrow)
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2747454&req=5

Figure 0007: Color-coded maps and time–attenuation curve (bottom right panel) from the umbra (arrow) showing significant reduction in the flow as compared with the normal side (block arrow)
Mentions: MTT, CBV, and CBF values from multiple areas under consideration on the affected as well as the normal hemisphere are obtained first. Then the MTT values are evaluated. If the MTT is raised as compared to the normal side, ischemia/infarction is present. Next, to differentiate ischemic and infarcted tissues, CBF and CBV values are compared. If CBF is reduced and CBV is normal or slightly reduced, the tissue ischemia is likely to be reversible [Figure 6]; if CBF and CBV are markedly reduced or if TTP is not measurable, the tissue may be infarcted [Figure 7].

Bottom Line: Stroke is a heterogeneous syndrome caused by multiple mechanisms, all of which result in disruption of normal cerebral blood flow and thereby cause cerebral dysfunction.Delay in diagnosis and treatment translates into increase neuronal loss and thereby increased morbidity.This article is an endeavor to explain the pathophysiology of cerebral ischemia and the role of CT perfusion in detecting it.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiodiagnosis and Imaging, PGIMER, Sector 12, Chandigarh, India.

ABSTRACT
Stroke is a heterogeneous syndrome caused by multiple mechanisms, all of which result in disruption of normal cerebral blood flow and thereby cause cerebral dysfunction. Its early diagnosis is important as its treatment is dependent on the time elapsed since ictus. Delay in diagnosis and treatment translates into increase neuronal loss and thereby increased morbidity. CT scan, and in particular perfusion CT, has helped greatly in the early diagnosis of stroke. This article is an endeavor to explain the pathophysiology of cerebral ischemia and the role of CT perfusion in detecting it.

No MeSH data available.


Related in: MedlinePlus