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Clinical applications of functional MRI in epilepsy.

Kesavadas C, Thomas B - Indian J Radiol Imaging (2008)

Bottom Line: It has become a noninvasive alternative to intraoperative cortical stimulation and the Wada test for eloquent cortex mapping and language lateralization, respectively.Its role in predicting postsurgical memory outcome and in localizing the ictal activity is being recognized.Illustrative cases have been discussed, wherein the fMRI results influenced the seizure team's decisions with regard to diagnosis and therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum - 695 011, India.

ABSTRACT
The role of functional MRI (fMRI) in the presurgical evaluation of patients with intractable epilepsy is being increasingly recognized. Real-time fMRI is an easily performable diagnostic technique in the clinical setting. It has become a noninvasive alternative to intraoperative cortical stimulation and the Wada test for eloquent cortex mapping and language lateralization, respectively. Its role in predicting postsurgical memory outcome and in localizing the ictal activity is being recognized. This review article describes the biophysical basis of blood-oxygen-level-dependent (BOLD) fMRI and the methodology adopted, including the design, paradigms, the fMRI setup, and data analysis. Illustrative cases have been discussed, wherein the fMRI results influenced the seizure team's decisions with regard to diagnosis and therapy. Finally, the special issues involved in fMRI of epilepsy patients and the various challenges of clinical fMRI are detailed.

No MeSH data available.


Related in: MedlinePlus

Event-related design: Stimuli repeated at variable intervals
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Figure 0003: Event-related design: Stimuli repeated at variable intervals

Mentions: An alternative approach, which is more physiological, is an ‘event’-related paradigm [Figure 3], in which discrete stimuli are repeated at variable times while scanning is in progress. However, this design needs longer acquisition times and is statistically more difficult to analyze and, hence, is used less often in clinical practice.


Clinical applications of functional MRI in epilepsy.

Kesavadas C, Thomas B - Indian J Radiol Imaging (2008)

Event-related design: Stimuli repeated at variable intervals
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2747426&req=5

Figure 0003: Event-related design: Stimuli repeated at variable intervals
Mentions: An alternative approach, which is more physiological, is an ‘event’-related paradigm [Figure 3], in which discrete stimuli are repeated at variable times while scanning is in progress. However, this design needs longer acquisition times and is statistically more difficult to analyze and, hence, is used less often in clinical practice.

Bottom Line: It has become a noninvasive alternative to intraoperative cortical stimulation and the Wada test for eloquent cortex mapping and language lateralization, respectively.Its role in predicting postsurgical memory outcome and in localizing the ictal activity is being recognized.Illustrative cases have been discussed, wherein the fMRI results influenced the seizure team's decisions with regard to diagnosis and therapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Imaging Sciences and Interventional Radiology, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum - 695 011, India.

ABSTRACT
The role of functional MRI (fMRI) in the presurgical evaluation of patients with intractable epilepsy is being increasingly recognized. Real-time fMRI is an easily performable diagnostic technique in the clinical setting. It has become a noninvasive alternative to intraoperative cortical stimulation and the Wada test for eloquent cortex mapping and language lateralization, respectively. Its role in predicting postsurgical memory outcome and in localizing the ictal activity is being recognized. This review article describes the biophysical basis of blood-oxygen-level-dependent (BOLD) fMRI and the methodology adopted, including the design, paradigms, the fMRI setup, and data analysis. Illustrative cases have been discussed, wherein the fMRI results influenced the seizure team's decisions with regard to diagnosis and therapy. Finally, the special issues involved in fMRI of epilepsy patients and the various challenges of clinical fMRI are detailed.

No MeSH data available.


Related in: MedlinePlus