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Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells.

Davies Cde L, Berk DA, Pluen A, Jain RK - Br. J. Cancer (2002)

Bottom Line: The tumour extracellular matrix acts as a barrier to the delivery of therapeutic agents.When grown as multicellular spheroids, no differences in either extracellular matrix composition or diffusion coefficient were found.Penetration of therapeutic macromolecules through tumour extracellular matrix might thus be largely determined by the host organ.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, MA 02110, USA.

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Related in: MedlinePlus

Haematoxylin-eosin stained sections of paraffin-embedded tumours (A) and multicellular spheroids (B). Images were obtained using 60× oil immersion objective. Bar=30 μm.
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fig3: Haematoxylin-eosin stained sections of paraffin-embedded tumours (A) and multicellular spheroids (B). Images were obtained using 60× oil immersion objective. Bar=30 μm.

Mentions: Haematoxylin-eosin stained sections of paraffin embedded tumours and spheroids showed a higher cell density in tumours growing in dorsal chambers compared to spheroids (Figure 3Figure 3


Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells.

Davies Cde L, Berk DA, Pluen A, Jain RK - Br. J. Cancer (2002)

Haematoxylin-eosin stained sections of paraffin-embedded tumours (A) and multicellular spheroids (B). Images were obtained using 60× oil immersion objective. Bar=30 μm.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2746604&req=5

fig3: Haematoxylin-eosin stained sections of paraffin-embedded tumours (A) and multicellular spheroids (B). Images were obtained using 60× oil immersion objective. Bar=30 μm.
Mentions: Haematoxylin-eosin stained sections of paraffin embedded tumours and spheroids showed a higher cell density in tumours growing in dorsal chambers compared to spheroids (Figure 3Figure 3

Bottom Line: The tumour extracellular matrix acts as a barrier to the delivery of therapeutic agents.When grown as multicellular spheroids, no differences in either extracellular matrix composition or diffusion coefficient were found.Penetration of therapeutic macromolecules through tumour extracellular matrix might thus be largely determined by the host organ.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, MA 02110, USA.

Show MeSH
Related in: MedlinePlus