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Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells.

Davies Cde L, Berk DA, Pluen A, Jain RK - Br. J. Cancer (2002)

Bottom Line: The tumour extracellular matrix acts as a barrier to the delivery of therapeutic agents.When grown as multicellular spheroids, no differences in either extracellular matrix composition or diffusion coefficient were found.Penetration of therapeutic macromolecules through tumour extracellular matrix might thus be largely determined by the host organ.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, MA 02110, USA.

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Collagen content in clone A, B, and C of BAHAN rhabdomyosarcoma growing as tumours or as multicellular spheroids. Each value represents the mean and standard error of 8–12 measurements of spheroids and 10 tumours. Significant difference between the clones is indicated (*).
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fig1: Collagen content in clone A, B, and C of BAHAN rhabdomyosarcoma growing as tumours or as multicellular spheroids. Each value represents the mean and standard error of 8–12 measurements of spheroids and 10 tumours. Significant difference between the clones is indicated (*).

Mentions: The three rhabdomyosarcoma clones exhibited different ECM composition when grown in vivo. In contrast, no difference in any of the measured ECM constituents was observed when the cells grew as multicellular spheroids (Figures 1Figure 1


Comparison of IgG diffusion and extracellular matrix composition in rhabdomyosarcomas grown in mice versus in vitro as spheroids reveals the role of host stromal cells.

Davies Cde L, Berk DA, Pluen A, Jain RK - Br. J. Cancer (2002)

Collagen content in clone A, B, and C of BAHAN rhabdomyosarcoma growing as tumours or as multicellular spheroids. Each value represents the mean and standard error of 8–12 measurements of spheroids and 10 tumours. Significant difference between the clones is indicated (*).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2746604&req=5

fig1: Collagen content in clone A, B, and C of BAHAN rhabdomyosarcoma growing as tumours or as multicellular spheroids. Each value represents the mean and standard error of 8–12 measurements of spheroids and 10 tumours. Significant difference between the clones is indicated (*).
Mentions: The three rhabdomyosarcoma clones exhibited different ECM composition when grown in vivo. In contrast, no difference in any of the measured ECM constituents was observed when the cells grew as multicellular spheroids (Figures 1Figure 1

Bottom Line: The tumour extracellular matrix acts as a barrier to the delivery of therapeutic agents.When grown as multicellular spheroids, no differences in either extracellular matrix composition or diffusion coefficient were found.Penetration of therapeutic macromolecules through tumour extracellular matrix might thus be largely determined by the host organ.

View Article: PubMed Central - PubMed

Affiliation: Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, MA 02110, USA.

Show MeSH
Related in: MedlinePlus