Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model.
Bottom Line: We found that a moderate dietary restriction of 30-40% significantly inhibited the intracerebral growth of the CT-2A syngeneic malignant mouse astrocytoma by almost 80%.These findings indicate that dietary restriction inhibited CT-2A growth by reducing angiogenesis and by enhancing apoptosis.Our data suggest that moderate dietary restriction may be an effective antiangiogenic therapy for recurrent malignant brain cancers.
Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, MA 02467, USA.Show MeSH
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Mentions: We next examined tumour morphology and blood vessel densities using H&E staining and Factor VIII immunostaining to determine if DR influenced tumour angiogenesis. Three independent tumours from the AL and DR groups were chosen at random for these studies. The number and size of blood vessels and tumour cell density were noticeably less in the DR-fed mice than in the AL-fed mice (Figure 3A,BFigure 3
Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, MA 02467, USA.