Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model.
Bottom Line: We found that a moderate dietary restriction of 30-40% significantly inhibited the intracerebral growth of the CT-2A syngeneic malignant mouse astrocytoma by almost 80%.These findings indicate that dietary restriction inhibited CT-2A growth by reducing angiogenesis and by enhancing apoptosis.Our data suggest that moderate dietary restriction may be an effective antiangiogenic therapy for recurrent malignant brain cancers.
Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, MA 02467, USA.Show MeSH
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Mentions: Our experimental design involved pretreatment with DR for 7 days prior to intracerebral tumour implantation. This was done to separate the physiological stress of single cage housing and food restriction from surgical brain trauma. A slight reduction in energy intake was noticed in both the AL-fed and the DR-fed mice at the initiation of the experiment (Figure 1Figure 1
Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, MA 02467, USA.