Limits...
Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model.

Mukherjee P, El-Abbadi MM, Kasperzyk JL, Ranes MK, Seyfried TN - Br. J. Cancer (2002)

Bottom Line: We found that a moderate dietary restriction of 30-40% significantly inhibited the intracerebral growth of the CT-2A syngeneic malignant mouse astrocytoma by almost 80%.These findings indicate that dietary restriction inhibited CT-2A growth by reducing angiogenesis and by enhancing apoptosis.Our data suggest that moderate dietary restriction may be an effective antiangiogenic therapy for recurrent malignant brain cancers.

View Article: PubMed Central - PubMed

Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, MA 02467, USA.

Show MeSH

Related in: MedlinePlus

Energy intake in male C57BL6/J mice bearing the intracerebral CT-2A brain tumour. DR was initiated on day 1 and tumours were implanted on day 8. Values are expressed as means±s.e.m. and n=the number of tumour-bearing mice examined in each group.
© Copyright Policy
Related In: Results  -  Collection


getmorefigures.php?uid=PMC2746602&req=5

fig1: Energy intake in male C57BL6/J mice bearing the intracerebral CT-2A brain tumour. DR was initiated on day 1 and tumours were implanted on day 8. Values are expressed as means±s.e.m. and n=the number of tumour-bearing mice examined in each group.

Mentions: Our experimental design involved pretreatment with DR for 7 days prior to intracerebral tumour implantation. This was done to separate the physiological stress of single cage housing and food restriction from surgical brain trauma. A slight reduction in energy intake was noticed in both the AL-fed and the DR-fed mice at the initiation of the experiment (Figure 1Figure 1


Dietary restriction reduces angiogenesis and growth in an orthotopic mouse brain tumour model.

Mukherjee P, El-Abbadi MM, Kasperzyk JL, Ranes MK, Seyfried TN - Br. J. Cancer (2002)

Energy intake in male C57BL6/J mice bearing the intracerebral CT-2A brain tumour. DR was initiated on day 1 and tumours were implanted on day 8. Values are expressed as means±s.e.m. and n=the number of tumour-bearing mice examined in each group.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2746602&req=5

fig1: Energy intake in male C57BL6/J mice bearing the intracerebral CT-2A brain tumour. DR was initiated on day 1 and tumours were implanted on day 8. Values are expressed as means±s.e.m. and n=the number of tumour-bearing mice examined in each group.
Mentions: Our experimental design involved pretreatment with DR for 7 days prior to intracerebral tumour implantation. This was done to separate the physiological stress of single cage housing and food restriction from surgical brain trauma. A slight reduction in energy intake was noticed in both the AL-fed and the DR-fed mice at the initiation of the experiment (Figure 1Figure 1

Bottom Line: We found that a moderate dietary restriction of 30-40% significantly inhibited the intracerebral growth of the CT-2A syngeneic malignant mouse astrocytoma by almost 80%.These findings indicate that dietary restriction inhibited CT-2A growth by reducing angiogenesis and by enhancing apoptosis.Our data suggest that moderate dietary restriction may be an effective antiangiogenic therapy for recurrent malignant brain cancers.

View Article: PubMed Central - PubMed

Affiliation: Biology Department, Boston College, Chestnut Hill, Massachusetts, MA 02467, USA.

Show MeSH
Related in: MedlinePlus