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Orthogonal polarisation spectral imaging as a new tool for the assessment of antivascular tumour treatment in vivo: a validation study.

Pahernik S, Harris AG, Schmitt-Sody M, Krasnici S, Goetz AE, Dellian M, Messmer K - Br. J. Cancer (2002)

Bottom Line: Correlation parameters for diameter of microvessels and red blood cell velocity were similar (r2=0.97, R(S)=0.99 and r2=0.93, R(S)=0.94 for diameter of microvessels and red blood cell velocity, respectively).Treatment with SU5416 reduced tumour angiogenesis.In addition to the inhibition of tumour angiogenesis, tumour growth and the development of metastasis was strongly reduced in SU5416 treated animals.

View Article: PubMed Central - PubMed

Affiliation: Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany. Pahernik@Urologie.Klinik.Uni-Mainz.de

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Correlation of functional microvessel density between OPS imaging and fluorescence microscopy and effect of SU5416 on tumour angiogenesis and tumour growth. (A) Linear regression analysis between these techniques, lines indicate 95% coinfidence and precision intervals. Correlation parameters for functional microvessel density revealed an excellent correlation for the tumours investigated (y=0.99x+0.48, r2=0.97, RS=0.98, P<0.05, n=180). (B) Agreement between these two identical measurement techniques illustrated as Bland–Altman analysis. Precision and bias calculated by the Bland–Altman analysis between these two measurements techniques was 8.22 cm−1 and −0.32 cm−1, respectively.
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fig3: Correlation of functional microvessel density between OPS imaging and fluorescence microscopy and effect of SU5416 on tumour angiogenesis and tumour growth. (A) Linear regression analysis between these techniques, lines indicate 95% coinfidence and precision intervals. Correlation parameters for functional microvessel density revealed an excellent correlation for the tumours investigated (y=0.99x+0.48, r2=0.97, RS=0.98, P<0.05, n=180). (B) Agreement between these two identical measurement techniques illustrated as Bland–Altman analysis. Precision and bias calculated by the Bland–Altman analysis between these two measurements techniques was 8.22 cm−1 and −0.32 cm−1, respectively.

Mentions: The ability of OPS imaging to analyse tumour angiogenesis was validated by quantifying the functional vessel density, defined as the length of red blood cell perfused capillaries per observation area. Results obtained were compared with data obtained by fluorescence microscopy which is regarded as gold standard for such measurements. Data of functional microvessel density obtained by the two methods revealed an excellent correlation for the tumours investigated (y=0.99x+0.48, r2=0.97, RS=0.98, P<0.05, n=180, Figure 3AFigure 3


Orthogonal polarisation spectral imaging as a new tool for the assessment of antivascular tumour treatment in vivo: a validation study.

Pahernik S, Harris AG, Schmitt-Sody M, Krasnici S, Goetz AE, Dellian M, Messmer K - Br. J. Cancer (2002)

Correlation of functional microvessel density between OPS imaging and fluorescence microscopy and effect of SU5416 on tumour angiogenesis and tumour growth. (A) Linear regression analysis between these techniques, lines indicate 95% coinfidence and precision intervals. Correlation parameters for functional microvessel density revealed an excellent correlation for the tumours investigated (y=0.99x+0.48, r2=0.97, RS=0.98, P<0.05, n=180). (B) Agreement between these two identical measurement techniques illustrated as Bland–Altman analysis. Precision and bias calculated by the Bland–Altman analysis between these two measurements techniques was 8.22 cm−1 and −0.32 cm−1, respectively.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2746600&req=5

fig3: Correlation of functional microvessel density between OPS imaging and fluorescence microscopy and effect of SU5416 on tumour angiogenesis and tumour growth. (A) Linear regression analysis between these techniques, lines indicate 95% coinfidence and precision intervals. Correlation parameters for functional microvessel density revealed an excellent correlation for the tumours investigated (y=0.99x+0.48, r2=0.97, RS=0.98, P<0.05, n=180). (B) Agreement between these two identical measurement techniques illustrated as Bland–Altman analysis. Precision and bias calculated by the Bland–Altman analysis between these two measurements techniques was 8.22 cm−1 and −0.32 cm−1, respectively.
Mentions: The ability of OPS imaging to analyse tumour angiogenesis was validated by quantifying the functional vessel density, defined as the length of red blood cell perfused capillaries per observation area. Results obtained were compared with data obtained by fluorescence microscopy which is regarded as gold standard for such measurements. Data of functional microvessel density obtained by the two methods revealed an excellent correlation for the tumours investigated (y=0.99x+0.48, r2=0.97, RS=0.98, P<0.05, n=180, Figure 3AFigure 3

Bottom Line: Correlation parameters for diameter of microvessels and red blood cell velocity were similar (r2=0.97, R(S)=0.99 and r2=0.93, R(S)=0.94 for diameter of microvessels and red blood cell velocity, respectively).Treatment with SU5416 reduced tumour angiogenesis.In addition to the inhibition of tumour angiogenesis, tumour growth and the development of metastasis was strongly reduced in SU5416 treated animals.

View Article: PubMed Central - PubMed

Affiliation: Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany. Pahernik@Urologie.Klinik.Uni-Mainz.de

Show MeSH
Related in: MedlinePlus