Orthogonal polarisation spectral imaging as a new tool for the assessment of antivascular tumour treatment in vivo: a validation study.
Bottom Line: Correlation parameters for diameter of microvessels and red blood cell velocity were similar (r2=0.97, R(S)=0.99 and r2=0.93, R(S)=0.94 for diameter of microvessels and red blood cell velocity, respectively).Treatment with SU5416 reduced tumour angiogenesis.In addition to the inhibition of tumour angiogenesis, tumour growth and the development of metastasis was strongly reduced in SU5416 treated animals.
Affiliation: Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany. Pahernik@Urologie.Klinik.Uni-Mainz.deShow MeSH
Related in: MedlinePlus
Mentions: The ability of OPS imaging to analyse tumour angiogenesis was validated by quantifying the functional vessel density, defined as the length of red blood cell perfused capillaries per observation area. Results obtained were compared with data obtained by fluorescence microscopy which is regarded as gold standard for such measurements. Data of functional microvessel density obtained by the two methods revealed an excellent correlation for the tumours investigated (y=0.99x+0.48, r2=0.97, RS=0.98, P<0.05, n=180, Figure 3AFigure 3
Affiliation: Institute for Surgical Research, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany. Pahernik@Urologie.Klinik.Uni-Mainz.de