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Apoptosis control and proliferation marker in human normal and neoplastic adrenocortical tissues.

Bernini GP, Moretti A, Viacava P, Bonadio AG, Iacconi P, Miccoli P, Salvetti A - Br. J. Cancer (2002)

Bottom Line: MIB-1 was expressed in all carcinomas with values (13.7+/-3.1%) significantly (P<0.0006) higher than in the other groups.In conclusion, the present data indicate that the apoptosis control and proliferation activity evaluated by the p53 and MIB-1 proteins are impaired in adrenal carcinomas but preserved in adenomas, independently of their functional status.Therefore, these immunohistochemical markers, overexpressed in carcinomas only, may be useful in the diagnosis of malignancy in adrenocortical tumours.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy. g.bernini@med.unipi.it

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Adrenocortical carcinoma with several p53 immunoreactive cells.
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fig2: Adrenocortical carcinoma with several p53 immunoreactive cells.

Mentions: Mean percentage (±s.e.m.) of p53 positive cells in normal cortex (N), Aldosterone-producing adenomas (APA), non-functioning adenomas (NFA) and carcinomas (CA).


Apoptosis control and proliferation marker in human normal and neoplastic adrenocortical tissues.

Bernini GP, Moretti A, Viacava P, Bonadio AG, Iacconi P, Miccoli P, Salvetti A - Br. J. Cancer (2002)

Adrenocortical carcinoma with several p53 immunoreactive cells.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2746588&req=5

fig2: Adrenocortical carcinoma with several p53 immunoreactive cells.
Mentions: Mean percentage (±s.e.m.) of p53 positive cells in normal cortex (N), Aldosterone-producing adenomas (APA), non-functioning adenomas (NFA) and carcinomas (CA).

Bottom Line: MIB-1 was expressed in all carcinomas with values (13.7+/-3.1%) significantly (P<0.0006) higher than in the other groups.In conclusion, the present data indicate that the apoptosis control and proliferation activity evaluated by the p53 and MIB-1 proteins are impaired in adrenal carcinomas but preserved in adenomas, independently of their functional status.Therefore, these immunohistochemical markers, overexpressed in carcinomas only, may be useful in the diagnosis of malignancy in adrenocortical tumours.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy. g.bernini@med.unipi.it

Show MeSH
Related in: MedlinePlus