Apoptosis control and proliferation marker in human normal and neoplastic adrenocortical tissues.
Bottom Line: MIB-1 was expressed in all carcinomas with values (13.7+/-3.1%) significantly (P<0.0006) higher than in the other groups.In conclusion, the present data indicate that the apoptosis control and proliferation activity evaluated by the p53 and MIB-1 proteins are impaired in adrenal carcinomas but preserved in adenomas, independently of their functional status.Therefore, these immunohistochemical markers, overexpressed in carcinomas only, may be useful in the diagnosis of malignancy in adrenocortical tumours.
Affiliation: Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy. firstname.lastname@example.orgShow MeSH
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Affiliation: Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy. email@example.com