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Apoptosis control and proliferation marker in human normal and neoplastic adrenocortical tissues.

Bernini GP, Moretti A, Viacava P, Bonadio AG, Iacconi P, Miccoli P, Salvetti A - Br. J. Cancer (2002)

Bottom Line: MIB-1 was expressed in all carcinomas with values (13.7+/-3.1%) significantly (P<0.0006) higher than in the other groups.Therefore, these immunohistochemical markers, overexpressed in carcinomas only, may be useful in the diagnosis of malignancy in adrenocortical tumours.Whether Bcl-2 positivity found in some carcinomas and non-functioning adenomas may constitute, in the latter, a negative prognostic marker is still unknown.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy. g.bernini@med.unipi.it

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Mean percentage (±s.e.m.) of p53 positive cells in normal cortex (N), Aldosterone-producing adenomas (APA), non-functioning adenomas (NFA) and carcinomas (CA).
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fig1: Mean percentage (±s.e.m.) of p53 positive cells in normal cortex (N), Aldosterone-producing adenomas (APA), non-functioning adenomas (NFA) and carcinomas (CA).

Mentions: No p53 protein was detected in any sample of N, APA and NFA. In contrast, p53 was expressed in 15 out of 16 (94%) CA and in 10 specimens the staining involved between 10–50% of the malignant cells (Figures 1Figure 1


Apoptosis control and proliferation marker in human normal and neoplastic adrenocortical tissues.

Bernini GP, Moretti A, Viacava P, Bonadio AG, Iacconi P, Miccoli P, Salvetti A - Br. J. Cancer (2002)

Mean percentage (±s.e.m.) of p53 positive cells in normal cortex (N), Aldosterone-producing adenomas (APA), non-functioning adenomas (NFA) and carcinomas (CA).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2746588&req=5

fig1: Mean percentage (±s.e.m.) of p53 positive cells in normal cortex (N), Aldosterone-producing adenomas (APA), non-functioning adenomas (NFA) and carcinomas (CA).
Mentions: No p53 protein was detected in any sample of N, APA and NFA. In contrast, p53 was expressed in 15 out of 16 (94%) CA and in 10 specimens the staining involved between 10–50% of the malignant cells (Figures 1Figure 1

Bottom Line: MIB-1 was expressed in all carcinomas with values (13.7+/-3.1%) significantly (P<0.0006) higher than in the other groups.Therefore, these immunohistochemical markers, overexpressed in carcinomas only, may be useful in the diagnosis of malignancy in adrenocortical tumours.Whether Bcl-2 positivity found in some carcinomas and non-functioning adenomas may constitute, in the latter, a negative prognostic marker is still unknown.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy. g.bernini@med.unipi.it

Show MeSH
Related in: MedlinePlus