Apoptosis control and proliferation marker in human normal and neoplastic adrenocortical tissues.
Bottom Line: MIB-1 was expressed in all carcinomas with values (13.7+/-3.1%) significantly (P<0.0006) higher than in the other groups.Therefore, these immunohistochemical markers, overexpressed in carcinomas only, may be useful in the diagnosis of malignancy in adrenocortical tumours.Whether Bcl-2 positivity found in some carcinomas and non-functioning adenomas may constitute, in the latter, a negative prognostic marker is still unknown.
Affiliation: Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy. email@example.comShow MeSH
Related in: MedlinePlus
Mentions: No p53 protein was detected in any sample of N, APA and NFA. In contrast, p53 was expressed in 15 out of 16 (94%) CA and in 10 specimens the staining involved between 10–50% of the malignant cells (Figures 1Figure 1
Affiliation: Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy. firstname.lastname@example.org