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Apoptosis control and proliferation marker in human normal and neoplastic adrenocortical tissues.

Bernini GP, Moretti A, Viacava P, Bonadio AG, Iacconi P, Miccoli P, Salvetti A - Br. J. Cancer (2002)

Bottom Line: MIB-1 was expressed in all carcinomas with values (13.7+/-3.1%) significantly (P<0.0006) higher than in the other groups.In conclusion, the present data indicate that the apoptosis control and proliferation activity evaluated by the p53 and MIB-1 proteins are impaired in adrenal carcinomas but preserved in adenomas, independently of their functional status.Therefore, these immunohistochemical markers, overexpressed in carcinomas only, may be useful in the diagnosis of malignancy in adrenocortical tumours.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy. g.bernini@med.unipi.it

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Mean percentage (±s.e.m.) of p53 positive cells in normal cortex (N), Aldosterone-producing adenomas (APA), non-functioning adenomas (NFA) and carcinomas (CA).
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fig1: Mean percentage (±s.e.m.) of p53 positive cells in normal cortex (N), Aldosterone-producing adenomas (APA), non-functioning adenomas (NFA) and carcinomas (CA).

Mentions: No p53 protein was detected in any sample of N, APA and NFA. In contrast, p53 was expressed in 15 out of 16 (94%) CA and in 10 specimens the staining involved between 10–50% of the malignant cells (Figures 1Figure 1


Apoptosis control and proliferation marker in human normal and neoplastic adrenocortical tissues.

Bernini GP, Moretti A, Viacava P, Bonadio AG, Iacconi P, Miccoli P, Salvetti A - Br. J. Cancer (2002)

Mean percentage (±s.e.m.) of p53 positive cells in normal cortex (N), Aldosterone-producing adenomas (APA), non-functioning adenomas (NFA) and carcinomas (CA).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2746588&req=5

fig1: Mean percentage (±s.e.m.) of p53 positive cells in normal cortex (N), Aldosterone-producing adenomas (APA), non-functioning adenomas (NFA) and carcinomas (CA).
Mentions: No p53 protein was detected in any sample of N, APA and NFA. In contrast, p53 was expressed in 15 out of 16 (94%) CA and in 10 specimens the staining involved between 10–50% of the malignant cells (Figures 1Figure 1

Bottom Line: MIB-1 was expressed in all carcinomas with values (13.7+/-3.1%) significantly (P<0.0006) higher than in the other groups.In conclusion, the present data indicate that the apoptosis control and proliferation activity evaluated by the p53 and MIB-1 proteins are impaired in adrenal carcinomas but preserved in adenomas, independently of their functional status.Therefore, these immunohistochemical markers, overexpressed in carcinomas only, may be useful in the diagnosis of malignancy in adrenocortical tumours.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, University of Pisa, Via Roma 67, 56100 Pisa, Italy. g.bernini@med.unipi.it

Show MeSH
Related in: MedlinePlus