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A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs.

Hori K, Saito S, Kubota K - Br. J. Cancer (2002)

Bottom Line: In every tumour, tumour blood flow began to decrease immediately after AC7700 administration and reached a minimum at approximately 30 min after injection.These results demonstrate that AC7700 is effective for tumours growing in various tissues and organs and for metastases.We conclude that tumour blood flow stanching induced by AC7700 may become an effective therapeutic strategy for all cancers, including refractory cancers because the therapeutic effect is independent of tumour site and specific type of cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Vascular Biology, Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan. k-hori@idac.tohoku.ac.jp

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Photomicrograph of a measured region in a renal tumour. A typical histological feature is present: glomerulus survives within the tumour. H&E-stained tissue section. Original magnification, ×400. Bar, 50 μm.
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fig3: Photomicrograph of a measured region in a renal tumour. A typical histological feature is present: glomerulus survives within the tumour. H&E-stained tissue section. Original magnification, ×400. Bar, 50 μm.

Mentions: In tumours within muscle, liver, and lymph nodes, no preexisting tissues remained within the regions measured. In particular, in lymph node metastases, even in very small growing foci (less than 4 mm in diameter), preexisting tissues were not observed (data not shown). In contrast, in renal tumours, even in tumours with a diameter greater than 8 mm, glomeruli survived within regions assayed (Figure 3Figure 3


A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs.

Hori K, Saito S, Kubota K - Br. J. Cancer (2002)

Photomicrograph of a measured region in a renal tumour. A typical histological feature is present: glomerulus survives within the tumour. H&E-stained tissue section. Original magnification, ×400. Bar, 50 μm.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2746587&req=5

fig3: Photomicrograph of a measured region in a renal tumour. A typical histological feature is present: glomerulus survives within the tumour. H&E-stained tissue section. Original magnification, ×400. Bar, 50 μm.
Mentions: In tumours within muscle, liver, and lymph nodes, no preexisting tissues remained within the regions measured. In particular, in lymph node metastases, even in very small growing foci (less than 4 mm in diameter), preexisting tissues were not observed (data not shown). In contrast, in renal tumours, even in tumours with a diameter greater than 8 mm, glomeruli survived within regions assayed (Figure 3Figure 3

Bottom Line: In every tumour, tumour blood flow began to decrease immediately after AC7700 administration and reached a minimum at approximately 30 min after injection.These results demonstrate that AC7700 is effective for tumours growing in various tissues and organs and for metastases.We conclude that tumour blood flow stanching induced by AC7700 may become an effective therapeutic strategy for all cancers, including refractory cancers because the therapeutic effect is independent of tumour site and specific type of cancer.

View Article: PubMed Central - PubMed

Affiliation: Department of Vascular Biology, Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan. k-hori@idac.tohoku.ac.jp

Show MeSH
Related in: MedlinePlus