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A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs.

Hori K, Saito S, Kubota K - Br. J. Cancer (2002)

Bottom Line: The change in tumour blood flow and the therapeutic effect of AC7700 on microtumours were observed directly by using Sato lung carcinoma implanted in a rat transparent chamber.In every tumour, tumour blood flow began to decrease immediately after AC7700 administration and reached a minimum at approximately 30 min after injection.These results demonstrate that AC7700 is effective for tumours growing in various tissues and organs and for metastases.

View Article: PubMed Central - PubMed

Affiliation: Department of Vascular Biology, Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan. k-hori@idac.tohoku.ac.jp

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Photomicrograph of a measured region in a renal tumour. A typical histological feature is present: glomerulus survives within the tumour. H&E-stained tissue section. Original magnification, ×400. Bar, 50 μm.
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fig3: Photomicrograph of a measured region in a renal tumour. A typical histological feature is present: glomerulus survives within the tumour. H&E-stained tissue section. Original magnification, ×400. Bar, 50 μm.

Mentions: In tumours within muscle, liver, and lymph nodes, no preexisting tissues remained within the regions measured. In particular, in lymph node metastases, even in very small growing foci (less than 4 mm in diameter), preexisting tissues were not observed (data not shown). In contrast, in renal tumours, even in tumours with a diameter greater than 8 mm, glomeruli survived within regions assayed (Figure 3Figure 3


A novel combretastatin A-4 derivative, AC7700, strongly stanches tumour blood flow and inhibits growth of tumours developing in various tissues and organs.

Hori K, Saito S, Kubota K - Br. J. Cancer (2002)

Photomicrograph of a measured region in a renal tumour. A typical histological feature is present: glomerulus survives within the tumour. H&E-stained tissue section. Original magnification, ×400. Bar, 50 μm.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2746587&req=5

fig3: Photomicrograph of a measured region in a renal tumour. A typical histological feature is present: glomerulus survives within the tumour. H&E-stained tissue section. Original magnification, ×400. Bar, 50 μm.
Mentions: In tumours within muscle, liver, and lymph nodes, no preexisting tissues remained within the regions measured. In particular, in lymph node metastases, even in very small growing foci (less than 4 mm in diameter), preexisting tissues were not observed (data not shown). In contrast, in renal tumours, even in tumours with a diameter greater than 8 mm, glomeruli survived within regions assayed (Figure 3Figure 3

Bottom Line: The change in tumour blood flow and the therapeutic effect of AC7700 on microtumours were observed directly by using Sato lung carcinoma implanted in a rat transparent chamber.In every tumour, tumour blood flow began to decrease immediately after AC7700 administration and reached a minimum at approximately 30 min after injection.These results demonstrate that AC7700 is effective for tumours growing in various tissues and organs and for metastases.

View Article: PubMed Central - PubMed

Affiliation: Department of Vascular Biology, Division of Cancer Control, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryomachi, Aoba-ku, Sendai 980-8575, Japan. k-hori@idac.tohoku.ac.jp

Show MeSH
Related in: MedlinePlus