Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2).
Bottom Line: Quercetin, the major flavonoid present in vegetables and fruit, exerts potential anticarcinogenic effects in animal models and cell cultures, but less is known about quercetin glucosides.The results of this study indicate that all dietary flavonoids studied (epicatechin, epigallocatechin gallate, gallic acid and quercetin-3-glucoside) show a significant antioxidant effect in a chemical model system, but only epigallocatechin gallate or gallic acid are able to interfere with the cell cycle in Caco2 cell lines.From a structural point of view, the galloyl moiety appears to be required for both the antioxidant and the antiproliferative effects.
Affiliation: National Institute of Food and Nutrition Research, Via Ardeatina 546, 00178, Rome, Italy. email@example.comShow MeSH
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Affiliation: National Institute of Food and Nutrition Research, Via Ardeatina 546, 00178, Rome, Italy. firstname.lastname@example.org