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Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2).

Salucci M, Stivala LA, Maiani G, Bugianesi R, Vannini V - Br. J. Cancer (2002)

Bottom Line: Quercetin, the major flavonoid present in vegetables and fruit, exerts potential anticarcinogenic effects in animal models and cell cultures, but less is known about quercetin glucosides.The results of this study indicate that all dietary flavonoids studied (epicatechin, epigallocatechin gallate, gallic acid and quercetin-3-glucoside) show a significant antioxidant effect in a chemical model system, but only epigallocatechin gallate or gallic acid are able to interfere with the cell cycle in Caco2 cell lines.From a structural point of view, the galloyl moiety appears to be required for both the antioxidant and the antiproliferative effects.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Food and Nutrition Research, Via Ardeatina 546, 00178, Rome, Italy. salucci@inran.it

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Time course of cellular uptake of EC, EGCG and IQ on Caco2 cells. Cells were incubated for 24, 48 and 72 h with 100 μM of EGCG, EC and with 70 μM of IQ, and the cellular uptake was analysed by HPLC. Three independent experiments were made. Bars indicate standard deviation of the mean. *P<0.05 (Anova test).
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fig3: Time course of cellular uptake of EC, EGCG and IQ on Caco2 cells. Cells were incubated for 24, 48 and 72 h with 100 μM of EGCG, EC and with 70 μM of IQ, and the cellular uptake was analysed by HPLC. Three independent experiments were made. Bars indicate standard deviation of the mean. *P<0.05 (Anova test).

Mentions: Figure 3Figure 3


Flavonoids uptake and their effect on cell cycle of human colon adenocarcinoma cells (Caco2).

Salucci M, Stivala LA, Maiani G, Bugianesi R, Vannini V - Br. J. Cancer (2002)

Time course of cellular uptake of EC, EGCG and IQ on Caco2 cells. Cells were incubated for 24, 48 and 72 h with 100 μM of EGCG, EC and with 70 μM of IQ, and the cellular uptake was analysed by HPLC. Three independent experiments were made. Bars indicate standard deviation of the mean. *P<0.05 (Anova test).
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2746583&req=5

fig3: Time course of cellular uptake of EC, EGCG and IQ on Caco2 cells. Cells were incubated for 24, 48 and 72 h with 100 μM of EGCG, EC and with 70 μM of IQ, and the cellular uptake was analysed by HPLC. Three independent experiments were made. Bars indicate standard deviation of the mean. *P<0.05 (Anova test).
Mentions: Figure 3Figure 3

Bottom Line: Quercetin, the major flavonoid present in vegetables and fruit, exerts potential anticarcinogenic effects in animal models and cell cultures, but less is known about quercetin glucosides.The results of this study indicate that all dietary flavonoids studied (epicatechin, epigallocatechin gallate, gallic acid and quercetin-3-glucoside) show a significant antioxidant effect in a chemical model system, but only epigallocatechin gallate or gallic acid are able to interfere with the cell cycle in Caco2 cell lines.From a structural point of view, the galloyl moiety appears to be required for both the antioxidant and the antiproliferative effects.

View Article: PubMed Central - PubMed

Affiliation: National Institute of Food and Nutrition Research, Via Ardeatina 546, 00178, Rome, Italy. salucci@inran.it

Show MeSH
Related in: MedlinePlus