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Expression of multidrug resistance-associated protein1,P-glycoprotein, and thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection.

Choi JH, Lim HY, Joo HJ, Kim HS, Yi JW, Kim HC, Cho YK, Kim MW, Lee KB - Br. J. Cancer (2002)

Bottom Line: There was a significant association between multidrug resistance-associated protein1 and P-glycoprotein expression (P<0.0001) as well as P-glycoprotein and thymidylate synthase expression (P<0.0001).There were no significant differences in disease-free survival and overall survival according to the expression of multidrug resistance-associated protein1 (P=0.902 and P=0.975, respectively), P-glycoprotein (P=0.987 and P=0.955, respectively), and thymidylate synthase (P=0.604 and P=0.802, respectively).Concurrent high expression of these proteins (high multidrug resistance-associated protein1/P-glycoprotein, high multidrug resistance-associated protein1/thymidylate synthase, high P-glycoprotein/thymidylate synthase) did not correlate with disease-free survival or overall survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, 442-721, Korea (Rep.).

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Related in: MedlinePlus

Disease-free survival (A) and overall survival (B) of gastric cancer patients according to TS expression.
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Related In: Results  -  Collection


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fig4: Disease-free survival (A) and overall survival (B) of gastric cancer patients according to TS expression.

Mentions: Disease-free survival (A) and overall survival (B) of gastric cancer patients according to P-gp expression.


Expression of multidrug resistance-associated protein1,P-glycoprotein, and thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection.

Choi JH, Lim HY, Joo HJ, Kim HS, Yi JW, Kim HC, Cho YK, Kim MW, Lee KB - Br. J. Cancer (2002)

Disease-free survival (A) and overall survival (B) of gastric cancer patients according to TS expression.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2746581&req=5

fig4: Disease-free survival (A) and overall survival (B) of gastric cancer patients according to TS expression.
Mentions: Disease-free survival (A) and overall survival (B) of gastric cancer patients according to P-gp expression.

Bottom Line: There was a significant association between multidrug resistance-associated protein1 and P-glycoprotein expression (P<0.0001) as well as P-glycoprotein and thymidylate synthase expression (P<0.0001).There were no significant differences in disease-free survival and overall survival according to the expression of multidrug resistance-associated protein1 (P=0.902 and P=0.975, respectively), P-glycoprotein (P=0.987 and P=0.955, respectively), and thymidylate synthase (P=0.604 and P=0.802, respectively).Concurrent high expression of these proteins (high multidrug resistance-associated protein1/P-glycoprotein, high multidrug resistance-associated protein1/thymidylate synthase, high P-glycoprotein/thymidylate synthase) did not correlate with disease-free survival or overall survival.

View Article: PubMed Central - PubMed

Affiliation: Department of Hematology-Oncology, Ajou University School of Medicine, Suwon, 442-721, Korea (Rep.).

Show MeSH
Related in: MedlinePlus