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The role of integrins in cancer and the development of anti-integrin therapeutic agents for cancer therapy.

Lu X, Lu D, Scully M, Kakkar V - Perspect Medicin Chem (2008)

Bottom Line: Integrins have been reported to mediate cell survival, proliferation, differentiation, and migration programs.For this reason, the past few years have seen an increased interest in the implications of integrin receptors in cancer biology and tumor cell aggression.It discusses of the several properties of the integrin-based chemotherapeutic agents currently under consideration clinically and provides an insight into cancer drug development using integrin as a target.

View Article: PubMed Central - PubMed

Affiliation: Thrombosis Research Institute, Manresa Road, London, SW3 6LR U.K.

ABSTRACT
Integrins have been reported to mediate cell survival, proliferation, differentiation, and migration programs. For this reason, the past few years have seen an increased interest in the implications of integrin receptors in cancer biology and tumor cell aggression. This review considers the potential role of integrins in cancer and also addresses why integrins are present attractive targets for drug design. It discusses of the several properties of the integrin-based chemotherapeutic agents currently under consideration clinically and provides an insight into cancer drug development using integrin as a target.

No MeSH data available.


Related in: MedlinePlus

Structure of the extracellular segment of αVβ3 derived with permission from Xiong et al. 2002. (A) Bent conformation of αVβ3 as it was present in the crystal. (B) Extension of the structure to reveal its domains.
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f1-pmc-2008-057: Structure of the extracellular segment of αVβ3 derived with permission from Xiong et al. 2002. (A) Bent conformation of αVβ3 as it was present in the crystal. (B) Extension of the structure to reveal its domains.

Mentions: The first three-dimensional structure of the extracellular domain of an integrin was published in October 2001, a decade and a half after the family was first defined (Xiong et al. 2001, 2002, 2004) (Fig. 1).


The role of integrins in cancer and the development of anti-integrin therapeutic agents for cancer therapy.

Lu X, Lu D, Scully M, Kakkar V - Perspect Medicin Chem (2008)

Structure of the extracellular segment of αVβ3 derived with permission from Xiong et al. 2002. (A) Bent conformation of αVβ3 as it was present in the crystal. (B) Extension of the structure to reveal its domains.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2746574&req=5

f1-pmc-2008-057: Structure of the extracellular segment of αVβ3 derived with permission from Xiong et al. 2002. (A) Bent conformation of αVβ3 as it was present in the crystal. (B) Extension of the structure to reveal its domains.
Mentions: The first three-dimensional structure of the extracellular domain of an integrin was published in October 2001, a decade and a half after the family was first defined (Xiong et al. 2001, 2002, 2004) (Fig. 1).

Bottom Line: Integrins have been reported to mediate cell survival, proliferation, differentiation, and migration programs.For this reason, the past few years have seen an increased interest in the implications of integrin receptors in cancer biology and tumor cell aggression.It discusses of the several properties of the integrin-based chemotherapeutic agents currently under consideration clinically and provides an insight into cancer drug development using integrin as a target.

View Article: PubMed Central - PubMed

Affiliation: Thrombosis Research Institute, Manresa Road, London, SW3 6LR U.K.

ABSTRACT
Integrins have been reported to mediate cell survival, proliferation, differentiation, and migration programs. For this reason, the past few years have seen an increased interest in the implications of integrin receptors in cancer biology and tumor cell aggression. This review considers the potential role of integrins in cancer and also addresses why integrins are present attractive targets for drug design. It discusses of the several properties of the integrin-based chemotherapeutic agents currently under consideration clinically and provides an insight into cancer drug development using integrin as a target.

No MeSH data available.


Related in: MedlinePlus