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Methicillin-resistant Staphylococcus aureus ST398 in swine farm personnel, Belgium.

Denis O, Suetens C, Hallin M, Catry B, Ramboer I, Dispas M, Willems G, Gordts B, Butaye P, Struelens MJ - Emerging Infect. Dis. (2009)

Bottom Line: We assessed methicillin-resistant Staphylococcus aureus (MRSA) in persons on 49 swine farms in Belgium.Surveys showed that 48 (37.8%) persons carried MRSA ST398 and 1 (0.8%) had concurrent skin infection.Risk factors for carriage were MRSA carriage by pigs, regular contact with pigs and companion animals, and use of protective clothing.

View Article: PubMed Central - PubMed

Affiliation: Université Libre de Bruxelles Hôpital Erasme, Brussels, Belgium. odenis@ulb.ac.be

ABSTRACT
We assessed methicillin-resistant Staphylococcus aureus (MRSA) in persons on 49 swine farms in Belgium. Surveys showed that 48 (37.8%) persons carried MRSA ST398 and 1 (0.8%) had concurrent skin infection. Risk factors for carriage were MRSA carriage by pigs, regular contact with pigs and companion animals, and use of protective clothing.

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Antimicrobial drug susceptibility of Staphylococcus aureus strains recovered from pig farmers, Belgium, 2007. MRSA, methicillin-resistant S. aureus; MSSA, methicillin-susceptible S. aureus.
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Figure 2: Antimicrobial drug susceptibility of Staphylococcus aureus strains recovered from pig farmers, Belgium, 2007. MRSA, methicillin-resistant S. aureus; MSSA, methicillin-susceptible S. aureus.

Mentions: The 48 MRSA isolates were nontypeable by SmaI; some harbored SCCmec type IVa (n = 26), type V (n = 20), or were nontypeable (n = 2), and some exhibited 3 related spa types, t011 (n = 45), t034 (n = 2), and t567 (n = 1) (Table 2). Of the spa types, 4 representative strains belonged to ST398. Of the strains, 94% were classified into 2 genotypes, t011-SCCmec type IVa and t011-SCCmec type V, each found on 14 and 10 farms, respectively. In 8 of 11 farms with >2 MRSA carriers, all carriers harbored the same spa-SCCmec genotype. On 17 of 24 farms with MRSA colonization of humans and pigs, both groups carried the same genotype, suggesting animal-to-human transmission (Figure 1). Of MRSA isolates, 40 (83%) were resistant to tetracycline, cotrimoxazole, macrolides-lincosamides, aminoglycosides, and ciprofloxacin (Figure 2). Nearly all strains were susceptible to fusidic acid and mupirocin; all were susceptible to linezolid, rifampin, and glycopeptides. Resistance to aminoglycosides was conferred by the aac(6′)–aph(2′′) gene (n = 23) and the ant(4′) gene (n = 9). Resistance to macrolides-lincosamides was mainly mediated by ermC gene (n = 24). Tetracycline resistance was encoded by tetM and tetK genes in 48 (100%) and 23 (50%) isolates, respectively. Resistance profiles were related to clonal types (Table 2).


Methicillin-resistant Staphylococcus aureus ST398 in swine farm personnel, Belgium.

Denis O, Suetens C, Hallin M, Catry B, Ramboer I, Dispas M, Willems G, Gordts B, Butaye P, Struelens MJ - Emerging Infect. Dis. (2009)

Antimicrobial drug susceptibility of Staphylococcus aureus strains recovered from pig farmers, Belgium, 2007. MRSA, methicillin-resistant S. aureus; MSSA, methicillin-susceptible S. aureus.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2744256&req=5

Figure 2: Antimicrobial drug susceptibility of Staphylococcus aureus strains recovered from pig farmers, Belgium, 2007. MRSA, methicillin-resistant S. aureus; MSSA, methicillin-susceptible S. aureus.
Mentions: The 48 MRSA isolates were nontypeable by SmaI; some harbored SCCmec type IVa (n = 26), type V (n = 20), or were nontypeable (n = 2), and some exhibited 3 related spa types, t011 (n = 45), t034 (n = 2), and t567 (n = 1) (Table 2). Of the spa types, 4 representative strains belonged to ST398. Of the strains, 94% were classified into 2 genotypes, t011-SCCmec type IVa and t011-SCCmec type V, each found on 14 and 10 farms, respectively. In 8 of 11 farms with >2 MRSA carriers, all carriers harbored the same spa-SCCmec genotype. On 17 of 24 farms with MRSA colonization of humans and pigs, both groups carried the same genotype, suggesting animal-to-human transmission (Figure 1). Of MRSA isolates, 40 (83%) were resistant to tetracycline, cotrimoxazole, macrolides-lincosamides, aminoglycosides, and ciprofloxacin (Figure 2). Nearly all strains were susceptible to fusidic acid and mupirocin; all were susceptible to linezolid, rifampin, and glycopeptides. Resistance to aminoglycosides was conferred by the aac(6′)–aph(2′′) gene (n = 23) and the ant(4′) gene (n = 9). Resistance to macrolides-lincosamides was mainly mediated by ermC gene (n = 24). Tetracycline resistance was encoded by tetM and tetK genes in 48 (100%) and 23 (50%) isolates, respectively. Resistance profiles were related to clonal types (Table 2).

Bottom Line: We assessed methicillin-resistant Staphylococcus aureus (MRSA) in persons on 49 swine farms in Belgium.Surveys showed that 48 (37.8%) persons carried MRSA ST398 and 1 (0.8%) had concurrent skin infection.Risk factors for carriage were MRSA carriage by pigs, regular contact with pigs and companion animals, and use of protective clothing.

View Article: PubMed Central - PubMed

Affiliation: Université Libre de Bruxelles Hôpital Erasme, Brussels, Belgium. odenis@ulb.ac.be

ABSTRACT
We assessed methicillin-resistant Staphylococcus aureus (MRSA) in persons on 49 swine farms in Belgium. Surveys showed that 48 (37.8%) persons carried MRSA ST398 and 1 (0.8%) had concurrent skin infection. Risk factors for carriage were MRSA carriage by pigs, regular contact with pigs and companion animals, and use of protective clothing.

Show MeSH
Related in: MedlinePlus