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Multiple origins of foot-and-mouth disease virus serotype Asia 1 outbreaks, 2003-2007.

Valarcher JF, Knowles NJ, Zakharov V, Scherbakov A, Zhang Z, Shang YJ, Liu ZX, Liu XT, Sanyal A, Hemadri D, Tosh C, Rasool TJ, Pattnaik B, Schumann KR, Beckham TR, Linchongsubongkoch W, Ferris NP, Roeder PL, Paton DJ - Emerging Infect. Dis. (2009)

Bottom Line: Since 2004, the region affected by outbreaks of this serotype has increased from disease-endemic countries in southern Asia (Afghanistan, India, Iran, Nepal, Pakistan) northward to encompass Kyrgyzstan, Tajikistan, Uzbekistan, several regions of the People's Republic of China, Mongolia, Eastern Russia, and North Korea.Some contemporary strains were genetically closely related to isolates collected historically from the region as far back as 25 years ago.Our analyses also indicated that some viruses have spread large distances between countries in Asia within a short time.

View Article: PubMed Central - PubMed

Affiliation: Institute for Animal Health, Pirbright, UK.

ABSTRACT
We investigated the molecular epidemiology of foot-and-mouth disease virus (FMDV) serotype Asia 1, which caused outbreaks of disease in Asia during 2003-2007. Since 2004, the region affected by outbreaks of this serotype has increased from disease-endemic countries in southern Asia (Afghanistan, India, Iran, Nepal, Pakistan) northward to encompass Kyrgyzstan, Tajikistan, Uzbekistan, several regions of the People's Republic of China, Mongolia, Eastern Russia, and North Korea. Phylogenetic analysis of complete virus capsid protein 1 (VP1) gene sequences demonstrated that the FMDV isolates responsible for these outbreaks belonged to 6 groups within the Asia 1 serotype. Some contemporary strains were genetically closely related to isolates collected historically from the region as far back as 25 years ago. Our analyses also indicated that some viruses have spread large distances between countries in Asia within a short time.

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Related in: MedlinePlus

Midpoint-rooted neighbor-joining tree showing the relationships between the complete VP1 sequences of Asia 1 foot-and-mouth disease virus isolates studied. Only the tree structure is shown; details of the labeled groups are given in Figure 3. Scale bar indicates nucleotide substitutions per site. The complete tree with all viruses labeled is shown in the Technical Appendix. SEA, group of viruses found in only in Southeast Asia and Hong Kong.
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Figure 2: Midpoint-rooted neighbor-joining tree showing the relationships between the complete VP1 sequences of Asia 1 foot-and-mouth disease virus isolates studied. Only the tree structure is shown; details of the labeled groups are given in Figure 3. Scale bar indicates nucleotide substitutions per site. The complete tree with all viruses labeled is shown in the Technical Appendix. SEA, group of viruses found in only in Southeast Asia and Hong Kong.

Mentions: The phylogenetic analysis of the complete VP1 gene sequences from isolates of serotype Asia 1 characterized in this study showed that recent viruses (isolated during 2003–2007) belonged to 6 different groups (I–VI) (Figure 2; Technical Appendix). These groups were defined by members of a group having 95%–100% nucleotide identity (Technical Appendix). All groups were supported by bootstrap values of 80%–100% (Technical Appendix) and were found by using alternative phylogenetic algorithms (maximum parsimony and maximum likelihood) (data not shown). Most virus groups were monophyletic. However, 1 group (VI) fell into 3 distinct lineages (a, b, c) and appeared to be ancestral to group II viruses (Figure 3, panel B). This grouping was also evident from the percentage identity matrix, in which the values between viruses in group VI and those in group II were 91.8%–95.9% (Technical Appendix). Relationships between groups II, III, and VI and between group IV and some unnumbered groups were also evident (Technical Appendix).


Multiple origins of foot-and-mouth disease virus serotype Asia 1 outbreaks, 2003-2007.

Valarcher JF, Knowles NJ, Zakharov V, Scherbakov A, Zhang Z, Shang YJ, Liu ZX, Liu XT, Sanyal A, Hemadri D, Tosh C, Rasool TJ, Pattnaik B, Schumann KR, Beckham TR, Linchongsubongkoch W, Ferris NP, Roeder PL, Paton DJ - Emerging Infect. Dis. (2009)

Midpoint-rooted neighbor-joining tree showing the relationships between the complete VP1 sequences of Asia 1 foot-and-mouth disease virus isolates studied. Only the tree structure is shown; details of the labeled groups are given in Figure 3. Scale bar indicates nucleotide substitutions per site. The complete tree with all viruses labeled is shown in the Technical Appendix. SEA, group of viruses found in only in Southeast Asia and Hong Kong.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2744236&req=5

Figure 2: Midpoint-rooted neighbor-joining tree showing the relationships between the complete VP1 sequences of Asia 1 foot-and-mouth disease virus isolates studied. Only the tree structure is shown; details of the labeled groups are given in Figure 3. Scale bar indicates nucleotide substitutions per site. The complete tree with all viruses labeled is shown in the Technical Appendix. SEA, group of viruses found in only in Southeast Asia and Hong Kong.
Mentions: The phylogenetic analysis of the complete VP1 gene sequences from isolates of serotype Asia 1 characterized in this study showed that recent viruses (isolated during 2003–2007) belonged to 6 different groups (I–VI) (Figure 2; Technical Appendix). These groups were defined by members of a group having 95%–100% nucleotide identity (Technical Appendix). All groups were supported by bootstrap values of 80%–100% (Technical Appendix) and were found by using alternative phylogenetic algorithms (maximum parsimony and maximum likelihood) (data not shown). Most virus groups were monophyletic. However, 1 group (VI) fell into 3 distinct lineages (a, b, c) and appeared to be ancestral to group II viruses (Figure 3, panel B). This grouping was also evident from the percentage identity matrix, in which the values between viruses in group VI and those in group II were 91.8%–95.9% (Technical Appendix). Relationships between groups II, III, and VI and between group IV and some unnumbered groups were also evident (Technical Appendix).

Bottom Line: Since 2004, the region affected by outbreaks of this serotype has increased from disease-endemic countries in southern Asia (Afghanistan, India, Iran, Nepal, Pakistan) northward to encompass Kyrgyzstan, Tajikistan, Uzbekistan, several regions of the People's Republic of China, Mongolia, Eastern Russia, and North Korea.Some contemporary strains were genetically closely related to isolates collected historically from the region as far back as 25 years ago.Our analyses also indicated that some viruses have spread large distances between countries in Asia within a short time.

View Article: PubMed Central - PubMed

Affiliation: Institute for Animal Health, Pirbright, UK.

ABSTRACT
We investigated the molecular epidemiology of foot-and-mouth disease virus (FMDV) serotype Asia 1, which caused outbreaks of disease in Asia during 2003-2007. Since 2004, the region affected by outbreaks of this serotype has increased from disease-endemic countries in southern Asia (Afghanistan, India, Iran, Nepal, Pakistan) northward to encompass Kyrgyzstan, Tajikistan, Uzbekistan, several regions of the People's Republic of China, Mongolia, Eastern Russia, and North Korea. Phylogenetic analysis of complete virus capsid protein 1 (VP1) gene sequences demonstrated that the FMDV isolates responsible for these outbreaks belonged to 6 groups within the Asia 1 serotype. Some contemporary strains were genetically closely related to isolates collected historically from the region as far back as 25 years ago. Our analyses also indicated that some viruses have spread large distances between countries in Asia within a short time.

Show MeSH
Related in: MedlinePlus