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Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.

Padhye S, Ahmad A, Oswal N, Sarkar FH - J Hematol Oncol (2009)

Bottom Line: Here we have summarized the progress of our current research knowledge on garcinol and its observed biological activities.We have also provided an explanation of observed properties based on its chemical structure and provided an insight into the structure and properties of chalcones, the precursors of garcinol.The available data is promising but more detailed investigations into the various properties of this compound, particularly its anti-cancer activity are urgently needed, and it is our hope that this review will stimulate further research for elucidating and appreciating the value of this nature's wonder agent.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Barbara Ann Karmanos Cancer Center and Wayne State University School of Medicine, Detroit, MI 48201, USA. sbpadhye@hotmail.com

ABSTRACT
Garcinol, harvested from Garcinia indica, has traditionally been used in tropical regions and appreciated for centuries; however its biological properties are only beginning to be elucidated. There is ample data to suggest potent antioxidant properties of this compound which have been used to explain most of its observed biological activities. However, emerging evidence suggests that garcinol could be useful as an anti-cancer agent, and it is increasingly being realized that garcinol is a pleiotropic agent capable of modulating key regulatory cell signaling pathways. Here we have summarized the progress of our current research knowledge on garcinol and its observed biological activities. We have also provided an explanation of observed properties based on its chemical structure and provided an insight into the structure and properties of chalcones, the precursors of garcinol. The available data is promising but more detailed investigations into the various properties of this compound, particularly its anti-cancer activity are urgently needed, and it is our hope that this review will stimulate further research for elucidating and appreciating the value of this nature's wonder agent.

Show MeSH
Structure of Garcinol, Curcumin and compounds extracted from Garcinia indica.
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Figure 1: Structure of Garcinol, Curcumin and compounds extracted from Garcinia indica.

Mentions: Garcinia indica extracts, especially from its rind, are rich in polyisoprenylated benzophenone derivatives such as Garcinol and its colorless isomer, Isogarcinol. The rind also contains hydroxycitric acid (HCA), hydroxycitric acid lactone, citric acid and oxalic acid. The structures of these compounds are shown in Figure 1. The fruit also contains other compounds including malic acid, polyphenols, carbohydrates, anthocyanin, pigments and ascorbic acid. Garcinol shows strong antioxidant activity since it contains both phenolic hydroxyl groups as well as a β-diketone moiety, and in this respect it resembles with the well-known antioxidant of plant origin, viz. Curcumin [5] (Figure 1).


Emerging role of Garcinol, the antioxidant chalcone from Garcinia indica Choisy and its synthetic analogs.

Padhye S, Ahmad A, Oswal N, Sarkar FH - J Hematol Oncol (2009)

Structure of Garcinol, Curcumin and compounds extracted from Garcinia indica.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2743703&req=5

Figure 1: Structure of Garcinol, Curcumin and compounds extracted from Garcinia indica.
Mentions: Garcinia indica extracts, especially from its rind, are rich in polyisoprenylated benzophenone derivatives such as Garcinol and its colorless isomer, Isogarcinol. The rind also contains hydroxycitric acid (HCA), hydroxycitric acid lactone, citric acid and oxalic acid. The structures of these compounds are shown in Figure 1. The fruit also contains other compounds including malic acid, polyphenols, carbohydrates, anthocyanin, pigments and ascorbic acid. Garcinol shows strong antioxidant activity since it contains both phenolic hydroxyl groups as well as a β-diketone moiety, and in this respect it resembles with the well-known antioxidant of plant origin, viz. Curcumin [5] (Figure 1).

Bottom Line: Here we have summarized the progress of our current research knowledge on garcinol and its observed biological activities.We have also provided an explanation of observed properties based on its chemical structure and provided an insight into the structure and properties of chalcones, the precursors of garcinol.The available data is promising but more detailed investigations into the various properties of this compound, particularly its anti-cancer activity are urgently needed, and it is our hope that this review will stimulate further research for elucidating and appreciating the value of this nature's wonder agent.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Barbara Ann Karmanos Cancer Center and Wayne State University School of Medicine, Detroit, MI 48201, USA. sbpadhye@hotmail.com

ABSTRACT
Garcinol, harvested from Garcinia indica, has traditionally been used in tropical regions and appreciated for centuries; however its biological properties are only beginning to be elucidated. There is ample data to suggest potent antioxidant properties of this compound which have been used to explain most of its observed biological activities. However, emerging evidence suggests that garcinol could be useful as an anti-cancer agent, and it is increasingly being realized that garcinol is a pleiotropic agent capable of modulating key regulatory cell signaling pathways. Here we have summarized the progress of our current research knowledge on garcinol and its observed biological activities. We have also provided an explanation of observed properties based on its chemical structure and provided an insight into the structure and properties of chalcones, the precursors of garcinol. The available data is promising but more detailed investigations into the various properties of this compound, particularly its anti-cancer activity are urgently needed, and it is our hope that this review will stimulate further research for elucidating and appreciating the value of this nature's wonder agent.

Show MeSH