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Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma.

Takemoto S, Ushijima K, Kawano K, Yamaguchi T, Terada A, Fujiyoshi N, Nishio S, Tsuda N, Ijichi M, Kakuma T, Kage M, Hori D, Kamura T - Br. J. Cancer (2009)

Bottom Line: Positive p-Stat3 expression was observed in 71 of 125 (56.8%) cases and was significantly correlated with lymph node metastasis, lymph vascular space invasion, and large tumour diameter (>4 cm) by Fisher's exact test.Kaplan-Meier survival analysis showed that p-Stat3 expression was statistically indicative of a poor prognosis for overall survival (P=0.006) and disease-free survival (P=0.010) by log-rank test.These data showed that p-Stat3 expression in cervical cancer acts as a predictor of poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Kurume University School of Medicine, Fukuoka, Japan. takemoto_shyuuji@kurume-u.ac.jp

ABSTRACT

Background: Stat3 is a member of the Janus-activated kinase/STAT signalling pathway. It normally resides in the cytoplasm and can be activated through phosphorylation. Activated Stat3 (p-Stat3) translocates to the nucleus to activate the transcription of several molecules involved in cell survival and proliferation. The constitutive activation of Stat3 has been shown in various types of malignancies, and its expression has been reported to indicate a poor prognosis. However, the correlation between the constitutive activation of Stat3 and the prognosis of cervical cancer patients has not been reported.

Methods: The immunohistochemical analysis of p-Stat3 expression was performed on tissues from 125 cervical squamous-cell carcinoma patients who underwent extended hysterectomy and pelvic lymphadenectomy, and the association of p-Stat3 expression with several clinicopathological factors and survival was investigated.

Results: Positive p-Stat3 expression was observed in 71 of 125 (56.8%) cases and was significantly correlated with lymph node metastasis, lymph vascular space invasion, and large tumour diameter (>4 cm) by Fisher's exact test. Kaplan-Meier survival analysis showed that p-Stat3 expression was statistically indicative of a poor prognosis for overall survival (P=0.006) and disease-free survival (P=0.010) by log-rank test.

Conclusion: These data showed that p-Stat3 expression in cervical cancer acts as a predictor of poor prognosis.

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Related in: MedlinePlus

Correlation between the number of metastatic lymph nodes and p-Stat3 expression. The percentages of ‘++,' ‘+,' and negative p-Stat3 expression in each group are plotted.
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fig2: Correlation between the number of metastatic lymph nodes and p-Stat3 expression. The percentages of ‘++,' ‘+,' and negative p-Stat3 expression in each group are plotted.

Mentions: Of the 32 patients with lymph node metastasis, 14 had one node, 7 had two nodes, and 11 had three or more nodes with metastasis. The percentage of p-Stat3 expression status in each group is shown in Figure 2. The relationship between p-Stat3 expression and these three groups was significant, accounting for ordered categories on both factors (P=0.022; Jonckheere–Terpstra test).


Expression of activated signal transducer and activator of transcription-3 predicts poor prognosis in cervical squamous-cell carcinoma.

Takemoto S, Ushijima K, Kawano K, Yamaguchi T, Terada A, Fujiyoshi N, Nishio S, Tsuda N, Ijichi M, Kakuma T, Kage M, Hori D, Kamura T - Br. J. Cancer (2009)

Correlation between the number of metastatic lymph nodes and p-Stat3 expression. The percentages of ‘++,' ‘+,' and negative p-Stat3 expression in each group are plotted.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2743356&req=5

fig2: Correlation between the number of metastatic lymph nodes and p-Stat3 expression. The percentages of ‘++,' ‘+,' and negative p-Stat3 expression in each group are plotted.
Mentions: Of the 32 patients with lymph node metastasis, 14 had one node, 7 had two nodes, and 11 had three or more nodes with metastasis. The percentage of p-Stat3 expression status in each group is shown in Figure 2. The relationship between p-Stat3 expression and these three groups was significant, accounting for ordered categories on both factors (P=0.022; Jonckheere–Terpstra test).

Bottom Line: Positive p-Stat3 expression was observed in 71 of 125 (56.8%) cases and was significantly correlated with lymph node metastasis, lymph vascular space invasion, and large tumour diameter (>4 cm) by Fisher's exact test.Kaplan-Meier survival analysis showed that p-Stat3 expression was statistically indicative of a poor prognosis for overall survival (P=0.006) and disease-free survival (P=0.010) by log-rank test.These data showed that p-Stat3 expression in cervical cancer acts as a predictor of poor prognosis.

View Article: PubMed Central - PubMed

Affiliation: Department of Obstetrics and Gynecology, Kurume University School of Medicine, Fukuoka, Japan. takemoto_shyuuji@kurume-u.ac.jp

ABSTRACT

Background: Stat3 is a member of the Janus-activated kinase/STAT signalling pathway. It normally resides in the cytoplasm and can be activated through phosphorylation. Activated Stat3 (p-Stat3) translocates to the nucleus to activate the transcription of several molecules involved in cell survival and proliferation. The constitutive activation of Stat3 has been shown in various types of malignancies, and its expression has been reported to indicate a poor prognosis. However, the correlation between the constitutive activation of Stat3 and the prognosis of cervical cancer patients has not been reported.

Methods: The immunohistochemical analysis of p-Stat3 expression was performed on tissues from 125 cervical squamous-cell carcinoma patients who underwent extended hysterectomy and pelvic lymphadenectomy, and the association of p-Stat3 expression with several clinicopathological factors and survival was investigated.

Results: Positive p-Stat3 expression was observed in 71 of 125 (56.8%) cases and was significantly correlated with lymph node metastasis, lymph vascular space invasion, and large tumour diameter (>4 cm) by Fisher's exact test. Kaplan-Meier survival analysis showed that p-Stat3 expression was statistically indicative of a poor prognosis for overall survival (P=0.006) and disease-free survival (P=0.010) by log-rank test.

Conclusion: These data showed that p-Stat3 expression in cervical cancer acts as a predictor of poor prognosis.

Show MeSH
Related in: MedlinePlus