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Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer.

Ng K, Wolpin BM, Meyerhardt JA, Wu K, Chan AT, Hollis BW, Giovannucci EL, Stampfer MJ, Willett WC, Fuchs CS - Br. J. Cancer (2009)

Bottom Line: Cox proportional hazards models were used to calculate hazard ratios (HRs) adjusted for other risk factors of survival.Higher predicted 25(OH)D levels were associated with a significant reduction in colorectal cancer-specific (P trend=0.02) and overall mortality (P trend=0.002).Compared with levels in the lowest quintile, participants with predicted 25(OH)D levels in the highest quintile had an adjusted HR of 0.50 (95% CI, 0.26-0.95) for cancer-specific mortality and 0.62 (95% CI, 0.42-0.93) for overall mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA. Kimmie_Ng@dfci.harvard.edu

ABSTRACT

Background: In an earlier study, a 25-hydroxyvitamin D(3) (25(OH)D) score calculated from known predictors of vitamin D status significantly predicted plasma levels of 25(OH)D and the risk of colorectal cancer, but the influence of the 25(OH)D score on survival after diagnosis is unknown.

Materials and methods: We prospectively examined the influence of post-diagnosis predicted 25(OH)D levels on mortality among 1017 participants in the Nurses' Health Study and Health Professionals Follow-Up Study who were diagnosed with colorectal cancer from 1986 to 2004. Colorectal cancer-specific and overall mortality according to quintiles of predicted 25(OH)D levels were assessed. Cox proportional hazards models were used to calculate hazard ratios (HRs) adjusted for other risk factors of survival.

Results: Higher predicted 25(OH)D levels were associated with a significant reduction in colorectal cancer-specific (P trend=0.02) and overall mortality (P trend=0.002). Compared with levels in the lowest quintile, participants with predicted 25(OH)D levels in the highest quintile had an adjusted HR of 0.50 (95% CI, 0.26-0.95) for cancer-specific mortality and 0.62 (95% CI, 0.42-0.93) for overall mortality.

Conclusion: Higher predicted 25(OH)D levels after a diagnosis of colorectal cancer may be associated with improved survival. Further study of the vitamin D pathway in colorectal cancer is warranted.

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Related in: MedlinePlus

(A) Colorectal cancer-specific survival according to tertile of post-diagnosis predicted 25(OH)D levels. (B) Overall survival according to tertile of post-diagnosis predicted 25(OH)D levels.
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fig1: (A) Colorectal cancer-specific survival according to tertile of post-diagnosis predicted 25(OH)D levels. (B) Overall survival according to tertile of post-diagnosis predicted 25(OH)D levels.

Mentions: Higher post-diagnosis predicted 25(OH)D levels were associated with a significant reduction in colorectal cancer-specific and overall mortality (Figure 1A and B, respectively, and Table 3). This relationship remained largely unchanged after adjusting for other predictors of cancer survival (Table 3). Compared with patients with post-diagnosis 25(OH)D scores in the lowest quintile, those in the highest quintile had an adjusted HR of 0.50 (95% CI, 0.26–0.95; P trend=0.02) for cancer-specific mortality and 0.62 (95% CI, 0.42–0.93; P trend=0.002) for overall mortality.


Prospective study of predictors of vitamin D status and survival in patients with colorectal cancer.

Ng K, Wolpin BM, Meyerhardt JA, Wu K, Chan AT, Hollis BW, Giovannucci EL, Stampfer MJ, Willett WC, Fuchs CS - Br. J. Cancer (2009)

(A) Colorectal cancer-specific survival according to tertile of post-diagnosis predicted 25(OH)D levels. (B) Overall survival according to tertile of post-diagnosis predicted 25(OH)D levels.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2743349&req=5

fig1: (A) Colorectal cancer-specific survival according to tertile of post-diagnosis predicted 25(OH)D levels. (B) Overall survival according to tertile of post-diagnosis predicted 25(OH)D levels.
Mentions: Higher post-diagnosis predicted 25(OH)D levels were associated with a significant reduction in colorectal cancer-specific and overall mortality (Figure 1A and B, respectively, and Table 3). This relationship remained largely unchanged after adjusting for other predictors of cancer survival (Table 3). Compared with patients with post-diagnosis 25(OH)D scores in the lowest quintile, those in the highest quintile had an adjusted HR of 0.50 (95% CI, 0.26–0.95; P trend=0.02) for cancer-specific mortality and 0.62 (95% CI, 0.42–0.93; P trend=0.002) for overall mortality.

Bottom Line: Cox proportional hazards models were used to calculate hazard ratios (HRs) adjusted for other risk factors of survival.Higher predicted 25(OH)D levels were associated with a significant reduction in colorectal cancer-specific (P trend=0.02) and overall mortality (P trend=0.002).Compared with levels in the lowest quintile, participants with predicted 25(OH)D levels in the highest quintile had an adjusted HR of 0.50 (95% CI, 0.26-0.95) for cancer-specific mortality and 0.62 (95% CI, 0.42-0.93) for overall mortality.

View Article: PubMed Central - PubMed

Affiliation: Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA. Kimmie_Ng@dfci.harvard.edu

ABSTRACT

Background: In an earlier study, a 25-hydroxyvitamin D(3) (25(OH)D) score calculated from known predictors of vitamin D status significantly predicted plasma levels of 25(OH)D and the risk of colorectal cancer, but the influence of the 25(OH)D score on survival after diagnosis is unknown.

Materials and methods: We prospectively examined the influence of post-diagnosis predicted 25(OH)D levels on mortality among 1017 participants in the Nurses' Health Study and Health Professionals Follow-Up Study who were diagnosed with colorectal cancer from 1986 to 2004. Colorectal cancer-specific and overall mortality according to quintiles of predicted 25(OH)D levels were assessed. Cox proportional hazards models were used to calculate hazard ratios (HRs) adjusted for other risk factors of survival.

Results: Higher predicted 25(OH)D levels were associated with a significant reduction in colorectal cancer-specific (P trend=0.02) and overall mortality (P trend=0.002). Compared with levels in the lowest quintile, participants with predicted 25(OH)D levels in the highest quintile had an adjusted HR of 0.50 (95% CI, 0.26-0.95) for cancer-specific mortality and 0.62 (95% CI, 0.42-0.93) for overall mortality.

Conclusion: Higher predicted 25(OH)D levels after a diagnosis of colorectal cancer may be associated with improved survival. Further study of the vitamin D pathway in colorectal cancer is warranted.

Show MeSH
Related in: MedlinePlus