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Concentration polarization of high-density lipoprotein and its relation with shear stress in an in vitro model.

Meng W, Yu F, Chen H, Zhang J, Zhang E, Dian K, Shi Y - J. Biomed. Biotechnol. (2009)

Bottom Line: HDL showed concentration polarization at the surface of the carotid artery model, particularly in the internal carotid artery sinus.With decreasing flow velocity, the shear stress at the surface also decreased, and HDL concentration polarization increased.The concentration polarization of HDL was negatively and strongly correlated with shear stress at both low- (r = -0.872, P < .001) and high-speed flow (r = -0.592, P = .0018).

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic and Cardiovascular Surgery, West China Medical Center, Sichuan University, Chengdu, China.

ABSTRACT
The purpose of this study was to determine the concentration polarization of high-density lipoprotein (HDL) at the surface of the carotid artery under conditions of steady flow and to establish its relationship with shear stress using an in vitro vascular simulation model of carotid bifurcation. Shear stress, HDL concentration at the surface, and the ratio of HDL concentration at the surface to concentration in bulk flow were measured at different locations within the model under high-speed (1.451 m/s) and low-speed (0.559 m/s) flow. HDL showed concentration polarization at the surface of the carotid artery model, particularly in the internal carotid artery sinus. With decreasing flow velocity, the shear stress at the surface also decreased, and HDL concentration polarization increased. The concentration polarization of HDL was negatively and strongly correlated with shear stress at both low- (r = -0.872, P < .001) and high-speed flow (r = -0.592, P = .0018).

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Scatter diagrams of shear stress and ratio of CS/C0 under low- and high-speed flow and correlation coefficients (r).
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Related In: Results  -  Collection


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fig5: Scatter diagrams of shear stress and ratio of CS/C0 under low- and high-speed flow and correlation coefficients (r).

Mentions: Concentration polarization of HDL (ratio of CS/C0 > 1.000) was present at all locations, except location 1 (control location of CCA) under low-speed flow. The data indicate that a reverse association exists between shear stress and both CS and the ratio of CS/C0 in that the lower the shear stress, the higher the CS and ratio of CS/C0 (Figure 5). In the correlation analysis, the ratio of CS/C0 was negatively and strongly correlated with shear stress at both low- and high-speed flow (correlation coefficient r = −0.872, P < .001; r = −0.592, P = .0018, resp.).


Concentration polarization of high-density lipoprotein and its relation with shear stress in an in vitro model.

Meng W, Yu F, Chen H, Zhang J, Zhang E, Dian K, Shi Y - J. Biomed. Biotechnol. (2009)

Scatter diagrams of shear stress and ratio of CS/C0 under low- and high-speed flow and correlation coefficients (r).
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2742649&req=5

fig5: Scatter diagrams of shear stress and ratio of CS/C0 under low- and high-speed flow and correlation coefficients (r).
Mentions: Concentration polarization of HDL (ratio of CS/C0 > 1.000) was present at all locations, except location 1 (control location of CCA) under low-speed flow. The data indicate that a reverse association exists between shear stress and both CS and the ratio of CS/C0 in that the lower the shear stress, the higher the CS and ratio of CS/C0 (Figure 5). In the correlation analysis, the ratio of CS/C0 was negatively and strongly correlated with shear stress at both low- and high-speed flow (correlation coefficient r = −0.872, P < .001; r = −0.592, P = .0018, resp.).

Bottom Line: HDL showed concentration polarization at the surface of the carotid artery model, particularly in the internal carotid artery sinus.With decreasing flow velocity, the shear stress at the surface also decreased, and HDL concentration polarization increased.The concentration polarization of HDL was negatively and strongly correlated with shear stress at both low- (r = -0.872, P < .001) and high-speed flow (r = -0.592, P = .0018).

View Article: PubMed Central - PubMed

Affiliation: Department of Thoracic and Cardiovascular Surgery, West China Medical Center, Sichuan University, Chengdu, China.

ABSTRACT
The purpose of this study was to determine the concentration polarization of high-density lipoprotein (HDL) at the surface of the carotid artery under conditions of steady flow and to establish its relationship with shear stress using an in vitro vascular simulation model of carotid bifurcation. Shear stress, HDL concentration at the surface, and the ratio of HDL concentration at the surface to concentration in bulk flow were measured at different locations within the model under high-speed (1.451 m/s) and low-speed (0.559 m/s) flow. HDL showed concentration polarization at the surface of the carotid artery model, particularly in the internal carotid artery sinus. With decreasing flow velocity, the shear stress at the surface also decreased, and HDL concentration polarization increased. The concentration polarization of HDL was negatively and strongly correlated with shear stress at both low- (r = -0.872, P < .001) and high-speed flow (r = -0.592, P = .0018).

Show MeSH