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Left cytoarchitectonic area 44 supports selection in the mental lexicon during language production.

Heim S, Eickhoff SB, Friederici AD, Amunts K - Brain Struct Funct (2009)

Bottom Line: Here, homogenous (priming) blocks in which German picture names had the same semantic category, syntactic gender, or initial phoneme alternated with heterogeneous (non-priming) blocks.The different effects in area 44 are discussed in terms of psycholinguistic theory.Overall, the activation pattern is in line with the hypothesis that area 44 generally supports selection processes during noun production at several levels of the mental lexicon.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany. sheim@ukaachen.de

ABSTRACT
This functional magnetic resonance imaging (fMRI) study investigated the role of Broca's region for selecting semantic, syntactic, and phonological information during picture naming. According to psycholinguistic theory, selection is reflected in speech latency differences, e.g. during priming. Here, homogenous (priming) blocks in which German picture names had the same semantic category, syntactic gender, or initial phoneme alternated with heterogeneous (non-priming) blocks. Speech latencies revealed a negative priming effect. Speech latencies were used as regressors for the fMRI data in order to tap selection processes. In Broca's region (BA 44), among others, fMRI data showed repetition priming, which was positive for semantic and syntactic but negative for phonological selection. The different effects in area 44 are discussed in terms of psycholinguistic theory. Overall, the activation pattern is in line with the hypothesis that area 44 generally supports selection processes during noun production at several levels of the mental lexicon.

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Top Left: Surface rendering of the main effect for picture naming in the fMRI data at an FWE-corrected (Pcorr < 0.05) and uncorrected (Puncorr < 0.001) threshold. Top Middle fMRI signal that is correlated with the speech latencies. Top Rightand Bottom Within the brain regions where the fMRI signal correlated with the speech latencies (Top Middle), the main effect for priming (i.e. homogeneous vs. heterogeneous trials in each condition) was significant (Puncorr < 0.001) in (1) area 44 in the left inferior frontal gyrus; (2) area 6 in the precentral gyrus; (3) the hippocampus and the postcentral gyrus (area 3b); (4) the posterior middle temporal gyrus; and (5) precuneus and the cerebellum
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Fig3: Top Left: Surface rendering of the main effect for picture naming in the fMRI data at an FWE-corrected (Pcorr < 0.05) and uncorrected (Puncorr < 0.001) threshold. Top Middle fMRI signal that is correlated with the speech latencies. Top Rightand Bottom Within the brain regions where the fMRI signal correlated with the speech latencies (Top Middle), the main effect for priming (i.e. homogeneous vs. heterogeneous trials in each condition) was significant (Puncorr < 0.001) in (1) area 44 in the left inferior frontal gyrus; (2) area 6 in the precentral gyrus; (3) the hippocampus and the postcentral gyrus (area 3b); (4) the posterior middle temporal gyrus; and (5) precuneus and the cerebellum

Mentions: The effect of interest for picture naming yielded widespread activation in the left hemisphere (Pcorr < 0.001). Within this network, some brain regions revealed a significant correlation with the speech latencies (Fig. 3 top middle; for cytoarchitectonic details cf. Table 1). These regions included the IFG (area 44/45; Amunts et al. 2004), insula, parietal operculum (areas OP1/OP2/OP4; Eickhoff et al. 2007a), superior temporal gyrus (area TE1.0; Morosan et al. 2001), middle temporal gyrus, precentral gyrus (areas 4a/4p/6; Geyer et al. 1996; Geyer 2003), postcental gyrus (areas 1/2/3a/3b; Geyer et al. 1999, 2000; Grefkes et al. 2001), superior and inferior occipital gyrus (areas 17/18; Amunts et al. 2000), hippocampus (subiculum, SUB; cornu ammonis, CA; entorhinal cortex, EC; Amunts et al. 2005) and amygdala (superficial group, SF; Amunts et al. 2005).Fig. 3


Left cytoarchitectonic area 44 supports selection in the mental lexicon during language production.

Heim S, Eickhoff SB, Friederici AD, Amunts K - Brain Struct Funct (2009)

Top Left: Surface rendering of the main effect for picture naming in the fMRI data at an FWE-corrected (Pcorr < 0.05) and uncorrected (Puncorr < 0.001) threshold. Top Middle fMRI signal that is correlated with the speech latencies. Top Rightand Bottom Within the brain regions where the fMRI signal correlated with the speech latencies (Top Middle), the main effect for priming (i.e. homogeneous vs. heterogeneous trials in each condition) was significant (Puncorr < 0.001) in (1) area 44 in the left inferior frontal gyrus; (2) area 6 in the precentral gyrus; (3) the hippocampus and the postcentral gyrus (area 3b); (4) the posterior middle temporal gyrus; and (5) precuneus and the cerebellum
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Related In: Results  -  Collection

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Fig3: Top Left: Surface rendering of the main effect for picture naming in the fMRI data at an FWE-corrected (Pcorr < 0.05) and uncorrected (Puncorr < 0.001) threshold. Top Middle fMRI signal that is correlated with the speech latencies. Top Rightand Bottom Within the brain regions where the fMRI signal correlated with the speech latencies (Top Middle), the main effect for priming (i.e. homogeneous vs. heterogeneous trials in each condition) was significant (Puncorr < 0.001) in (1) area 44 in the left inferior frontal gyrus; (2) area 6 in the precentral gyrus; (3) the hippocampus and the postcentral gyrus (area 3b); (4) the posterior middle temporal gyrus; and (5) precuneus and the cerebellum
Mentions: The effect of interest for picture naming yielded widespread activation in the left hemisphere (Pcorr < 0.001). Within this network, some brain regions revealed a significant correlation with the speech latencies (Fig. 3 top middle; for cytoarchitectonic details cf. Table 1). These regions included the IFG (area 44/45; Amunts et al. 2004), insula, parietal operculum (areas OP1/OP2/OP4; Eickhoff et al. 2007a), superior temporal gyrus (area TE1.0; Morosan et al. 2001), middle temporal gyrus, precentral gyrus (areas 4a/4p/6; Geyer et al. 1996; Geyer 2003), postcental gyrus (areas 1/2/3a/3b; Geyer et al. 1999, 2000; Grefkes et al. 2001), superior and inferior occipital gyrus (areas 17/18; Amunts et al. 2000), hippocampus (subiculum, SUB; cornu ammonis, CA; entorhinal cortex, EC; Amunts et al. 2005) and amygdala (superficial group, SF; Amunts et al. 2005).Fig. 3

Bottom Line: Here, homogenous (priming) blocks in which German picture names had the same semantic category, syntactic gender, or initial phoneme alternated with heterogeneous (non-priming) blocks.The different effects in area 44 are discussed in terms of psycholinguistic theory.Overall, the activation pattern is in line with the hypothesis that area 44 generally supports selection processes during noun production at several levels of the mental lexicon.

View Article: PubMed Central - PubMed

Affiliation: Department of Psychiatry and Psychotherapy, RWTH Aachen University, Pauwelsstrasse 30, 52074, Aachen, Germany. sheim@ukaachen.de

ABSTRACT
This functional magnetic resonance imaging (fMRI) study investigated the role of Broca's region for selecting semantic, syntactic, and phonological information during picture naming. According to psycholinguistic theory, selection is reflected in speech latency differences, e.g. during priming. Here, homogenous (priming) blocks in which German picture names had the same semantic category, syntactic gender, or initial phoneme alternated with heterogeneous (non-priming) blocks. Speech latencies revealed a negative priming effect. Speech latencies were used as regressors for the fMRI data in order to tap selection processes. In Broca's region (BA 44), among others, fMRI data showed repetition priming, which was positive for semantic and syntactic but negative for phonological selection. The different effects in area 44 are discussed in terms of psycholinguistic theory. Overall, the activation pattern is in line with the hypothesis that area 44 generally supports selection processes during noun production at several levels of the mental lexicon.

Show MeSH
Related in: MedlinePlus