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Lower serum testosterone associated with elevated polychlorinated biphenyl concentrations in Native American men.

Goncharov A, Rej R, Negoita S, Schymura M, Santiago-Rivera A, Morse G, Akwesasne Task Force on the EnvironmentCarpenter DO - Environ. Health Perspect. (2009)

Bottom Line: Testosterone concentrations in females are much lower than in males, and not significantly related to serum PCBs.HCB, DDE, and mirex were not associated with testosterone concentration in either men or women.Elevation in serum PCB levels is associated with a lower concentration of serum testosterone in Native American men.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental Health Sciences, University at Albany, 5 University Place, Rensselaer, NY 12144, USA.

ABSTRACT

Background: Polychlorinated biphenyls (PCBs) and chlorinated pesticides are endocrine disruptors, altering both thyroid and estrogen hormonal systems. Less is known of action on androgenic systems.

Objective: We studied the relationship between serum concentrations of testosterone in relation to levels of PCBs and three chlorinated pesticides in an adult Native American (Mohawk) population.

Methods: We collected fasting serum samples from 703 adult Mohawks (257 men and 436 women) and analyzed samples for 101 PCB congeners, hexachlorobenzene (HCB), dichlorodiphenyldichloroethylene (DDE), and mirex, as well as testosterone, cholesterol, and triglycerides. The associations between testosterone and tertiles of serum organochlorine levels (both wet weight and lipid adjusted) were assessed using a logistic regression model while controlling for age, body mass index (BMI), and other analytes, with the lowest tertile being considered the referent. Males and females were considered separately.

Results: Testosterone concentrations in males were inversely correlated with total PCB concentration, whether using wet-weight or lipid-adjusted values. The odds ratio (OR) of having a testosterone concentration above the median was 0.17 [95% confidence interval (CI), 0.05-0.69] for total wet-weight PCBs (highest vs. lowest tertile) after adjustment for age, BMI, total serum lipids, and three pesticides. The OR for lipid-adjusted total PCB concentration was 0.23 (95% CI, 0.06-0.78) after adjustment for other analytes. Testosterone levels were significantly and inversely related to concentrations of PCBs 74, 99, 153, and 206, but not PCBs 52, 105, 118, 138, 170, 180, 201, or 203. Testosterone concentrations in females are much lower than in males, and not significantly related to serum PCBs. HCB, DDE, and mirex were not associated with testosterone concentration in either men or women.

Conclusions: Elevation in serum PCB levels is associated with a lower concentration of serum testosterone in Native American men.

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Related in: MedlinePlus

ORs (A) and RRs (B) showing association of testosterone levels in men with tertile of total PCBs expressed as either wet-weight (with lipids as a covariate) or lipid-adjusted values. Error bars show 95% CIs.
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f2-ehp-117-1454: ORs (A) and RRs (B) showing association of testosterone levels in men with tertile of total PCBs expressed as either wet-weight (with lipids as a covariate) or lipid-adjusted values. Error bars show 95% CIs.

Mentions: Figure 2 shows the association between testosterone concentration and levels of total serum PCBs in tertiles in males. Figure 2A shows results by logistic regression, whereas Figure 2B shows the more stringent log-binomial regression. We observed a significant inverse association (OR = 0.17; RR = 0.77) between serum testosterone and highest versus lowest tertile of total wet-weight PCBs after adjustment for age, BMI, total serum lipids, and concentrations of the three pesticides. When the PCB concentration was expressed after lipid adjustment, the relationship was very similar (OR = 0.22; RR = 0.80) after concurrent adjustment for pesticides. There was no significant association between testosterone and any of the three pesticides, whether considered as wet-weight or lipid-adjusted concentrations. For wet-weight measurements for HCB, OR = 0.54 [95% confidence interval (CI), 0.19–1.55]; for DDE, OR = 1.18 (95% CI, 0.37–3.69); and for mirex, OR = 1.30 (95% CI, 0.48–3.48) comparing highest with lowest tertiles.


Lower serum testosterone associated with elevated polychlorinated biphenyl concentrations in Native American men.

Goncharov A, Rej R, Negoita S, Schymura M, Santiago-Rivera A, Morse G, Akwesasne Task Force on the EnvironmentCarpenter DO - Environ. Health Perspect. (2009)

ORs (A) and RRs (B) showing association of testosterone levels in men with tertile of total PCBs expressed as either wet-weight (with lipids as a covariate) or lipid-adjusted values. Error bars show 95% CIs.
© Copyright Policy - public-domain
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2737025&req=5

f2-ehp-117-1454: ORs (A) and RRs (B) showing association of testosterone levels in men with tertile of total PCBs expressed as either wet-weight (with lipids as a covariate) or lipid-adjusted values. Error bars show 95% CIs.
Mentions: Figure 2 shows the association between testosterone concentration and levels of total serum PCBs in tertiles in males. Figure 2A shows results by logistic regression, whereas Figure 2B shows the more stringent log-binomial regression. We observed a significant inverse association (OR = 0.17; RR = 0.77) between serum testosterone and highest versus lowest tertile of total wet-weight PCBs after adjustment for age, BMI, total serum lipids, and concentrations of the three pesticides. When the PCB concentration was expressed after lipid adjustment, the relationship was very similar (OR = 0.22; RR = 0.80) after concurrent adjustment for pesticides. There was no significant association between testosterone and any of the three pesticides, whether considered as wet-weight or lipid-adjusted concentrations. For wet-weight measurements for HCB, OR = 0.54 [95% confidence interval (CI), 0.19–1.55]; for DDE, OR = 1.18 (95% CI, 0.37–3.69); and for mirex, OR = 1.30 (95% CI, 0.48–3.48) comparing highest with lowest tertiles.

Bottom Line: Testosterone concentrations in females are much lower than in males, and not significantly related to serum PCBs.HCB, DDE, and mirex were not associated with testosterone concentration in either men or women.Elevation in serum PCB levels is associated with a lower concentration of serum testosterone in Native American men.

View Article: PubMed Central - PubMed

Affiliation: Department of Environmental Health Sciences, University at Albany, 5 University Place, Rensselaer, NY 12144, USA.

ABSTRACT

Background: Polychlorinated biphenyls (PCBs) and chlorinated pesticides are endocrine disruptors, altering both thyroid and estrogen hormonal systems. Less is known of action on androgenic systems.

Objective: We studied the relationship between serum concentrations of testosterone in relation to levels of PCBs and three chlorinated pesticides in an adult Native American (Mohawk) population.

Methods: We collected fasting serum samples from 703 adult Mohawks (257 men and 436 women) and analyzed samples for 101 PCB congeners, hexachlorobenzene (HCB), dichlorodiphenyldichloroethylene (DDE), and mirex, as well as testosterone, cholesterol, and triglycerides. The associations between testosterone and tertiles of serum organochlorine levels (both wet weight and lipid adjusted) were assessed using a logistic regression model while controlling for age, body mass index (BMI), and other analytes, with the lowest tertile being considered the referent. Males and females were considered separately.

Results: Testosterone concentrations in males were inversely correlated with total PCB concentration, whether using wet-weight or lipid-adjusted values. The odds ratio (OR) of having a testosterone concentration above the median was 0.17 [95% confidence interval (CI), 0.05-0.69] for total wet-weight PCBs (highest vs. lowest tertile) after adjustment for age, BMI, total serum lipids, and three pesticides. The OR for lipid-adjusted total PCB concentration was 0.23 (95% CI, 0.06-0.78) after adjustment for other analytes. Testosterone levels were significantly and inversely related to concentrations of PCBs 74, 99, 153, and 206, but not PCBs 52, 105, 118, 138, 170, 180, 201, or 203. Testosterone concentrations in females are much lower than in males, and not significantly related to serum PCBs. HCB, DDE, and mirex were not associated with testosterone concentration in either men or women.

Conclusions: Elevation in serum PCB levels is associated with a lower concentration of serum testosterone in Native American men.

Show MeSH
Related in: MedlinePlus