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A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers.

Fang RC, Galiano RD - Biologics (2008)

Bottom Line: Diabetic neuropathic foot ulcers represent a serious health care burden to patients and to society.This review examines the scientific underpinnings supporting the use of becaplermin (Regranex((R)); Ortho-McNeil Pharmaceutical, Raritan, NJ), or recombinant human platelet-derived growth factor (rhPDGF-BB), in diabetic forefoot wounds.A focus on the cost-effectiveness of this form of therapy in the treatment of diabetic foot ulcers is also outlined.

View Article: PubMed Central - PubMed

Affiliation: Division of Plastic and Reconstructive Surgery and Wound Healing Research Laboratory, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

ABSTRACT
Diabetic neuropathic foot ulcers represent a serious health care burden to patients and to society. While the management of chronic diabetic foot ulcers has improved in recent years, it remains a frustrating problem for a variety of clinicians. This review examines the scientific underpinnings supporting the use of becaplermin (Regranex((R)); Ortho-McNeil Pharmaceutical, Raritan, NJ), or recombinant human platelet-derived growth factor (rhPDGF-BB), in diabetic forefoot wounds. An emphasis is placed upon proper medical and surgical care of diabetic foot wounds, as multiple studies have demonstrated that the success of this growth factor in accelerating healing is ultimately dependent on proper ulcer care. A focus on the cost-effectiveness of this form of therapy in the treatment of diabetic foot ulcers is also outlined.

No MeSH data available.


Related in: MedlinePlus

Hyperglycemia induces biochemical derangements in susceptible cells that increases free radical production, activates 4 pathways of cellular damage, and culminates in the complications that are seen in diabetic individuals.
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f1-btt-2-1: Hyperglycemia induces biochemical derangements in susceptible cells that increases free radical production, activates 4 pathways of cellular damage, and culminates in the complications that are seen in diabetic individuals.

Mentions: The molecular pathways that culminate in wound healing deficiencies in diabetic individuals have been the focus of numerous studies. From a biochemical approach, metabolic mechanisms have been demonstrated to result in increased oxidative stress in cell types susceptible to hyperglycemia. Brownlee (2005) has recently laid out a unifying hypothesis that places the overproduction of reactive oxygen species (ROS) at the center of the four main biochemical derangements present in hyperglycemia: (1) overstimulation of the protein kinase C (PKC) signaling pathway, (2) overproduction and accumulation of advanced glycation end products (AGES), (3) increased accumulation of the sorbitol pathway, and (4) increased flux through the hexosamine pathway (Figure 1).


A review of becaplermin gel in the treatment of diabetic neuropathic foot ulcers.

Fang RC, Galiano RD - Biologics (2008)

Hyperglycemia induces biochemical derangements in susceptible cells that increases free radical production, activates 4 pathways of cellular damage, and culminates in the complications that are seen in diabetic individuals.
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2727777&req=5

f1-btt-2-1: Hyperglycemia induces biochemical derangements in susceptible cells that increases free radical production, activates 4 pathways of cellular damage, and culminates in the complications that are seen in diabetic individuals.
Mentions: The molecular pathways that culminate in wound healing deficiencies in diabetic individuals have been the focus of numerous studies. From a biochemical approach, metabolic mechanisms have been demonstrated to result in increased oxidative stress in cell types susceptible to hyperglycemia. Brownlee (2005) has recently laid out a unifying hypothesis that places the overproduction of reactive oxygen species (ROS) at the center of the four main biochemical derangements present in hyperglycemia: (1) overstimulation of the protein kinase C (PKC) signaling pathway, (2) overproduction and accumulation of advanced glycation end products (AGES), (3) increased accumulation of the sorbitol pathway, and (4) increased flux through the hexosamine pathway (Figure 1).

Bottom Line: Diabetic neuropathic foot ulcers represent a serious health care burden to patients and to society.This review examines the scientific underpinnings supporting the use of becaplermin (Regranex((R)); Ortho-McNeil Pharmaceutical, Raritan, NJ), or recombinant human platelet-derived growth factor (rhPDGF-BB), in diabetic forefoot wounds.A focus on the cost-effectiveness of this form of therapy in the treatment of diabetic foot ulcers is also outlined.

View Article: PubMed Central - PubMed

Affiliation: Division of Plastic and Reconstructive Surgery and Wound Healing Research Laboratory, Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

ABSTRACT
Diabetic neuropathic foot ulcers represent a serious health care burden to patients and to society. While the management of chronic diabetic foot ulcers has improved in recent years, it remains a frustrating problem for a variety of clinicians. This review examines the scientific underpinnings supporting the use of becaplermin (Regranex((R)); Ortho-McNeil Pharmaceutical, Raritan, NJ), or recombinant human platelet-derived growth factor (rhPDGF-BB), in diabetic forefoot wounds. An emphasis is placed upon proper medical and surgical care of diabetic foot wounds, as multiple studies have demonstrated that the success of this growth factor in accelerating healing is ultimately dependent on proper ulcer care. A focus on the cost-effectiveness of this form of therapy in the treatment of diabetic foot ulcers is also outlined.

No MeSH data available.


Related in: MedlinePlus