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Primary leptomeningeal oligodendrogliomatosis.

Mathews MS, Paré LS, Kuo JV, Kim RC - J. Neurooncol. (2009)

Bottom Line: Primary leptomeningeal oligodendrogliomas (PLOs) are rare intracranial malignancies where tumors grow in the subarachnoid space without an obvious connection to the brain or spinal cord parenchyma.Adding to the three previously reported cases of PLO with no parenchymal involvement we report a fourth case of the same in this paper in a 50-year-old woman presenting with unrelenting headaches.Our case suggests that PLO can mimic diffuse forms of granulomatous meningitis and should be suspected in patients that clinically and radiographically present like granulomatous meningitis but without blood or CSF markers for the same.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurological Surgery, State University New York at Buffalo, Buffalo, USA. mmathews@buffns.com

ABSTRACT
Primary leptomeningeal oligodendrogliomas (PLOs) are rare intracranial malignancies where tumors grow in the subarachnoid space without an obvious connection to the brain or spinal cord parenchyma. Adding to the three previously reported cases of PLO with no parenchymal involvement we report a fourth case of the same in this paper in a 50-year-old woman presenting with unrelenting headaches. CT scan of her head revealed hydrocephalus and MRI revealed diffuse enhancement of her leptomeninges throughout her brain and spine, prominent over the basilar region. Biopsy obtained using a frameless stereotactic biopsy showed sharply defined cell borders, clear cytoplasm, and rounded nuclei consistent with an oligodendroglioma. Our case suggests that PLO can mimic diffuse forms of granulomatous meningitis and should be suspected in patients that clinically and radiographically present like granulomatous meningitis but without blood or CSF markers for the same.

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Hematoxylin-eosin stained biopsy specimen under high magnification shows tumor cells with the sharply defined cell borders, clear cytoplasm, and rounded nuclei
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Fig2: Hematoxylin-eosin stained biopsy specimen under high magnification shows tumor cells with the sharply defined cell borders, clear cytoplasm, and rounded nuclei

Mentions: Biopsy findings showed tumor cells with sharply defined cell borders, clear cytoplasm, and rounded nuclei consistent with an oligodendroglioma (Fig. 2). The pathologic specimens were negative for 1p or 19q chromosomal deletions. These findings were present when read at our institution as well as that of a large center where the tissue specimen were sent for histopathologic confirmation. The tissue did not stain with immunohistochemical stains for systemic cancers (such as cytokeratin).Fig. 2


Primary leptomeningeal oligodendrogliomatosis.

Mathews MS, Paré LS, Kuo JV, Kim RC - J. Neurooncol. (2009)

Hematoxylin-eosin stained biopsy specimen under high magnification shows tumor cells with the sharply defined cell borders, clear cytoplasm, and rounded nuclei
© Copyright Policy
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2724631&req=5

Fig2: Hematoxylin-eosin stained biopsy specimen under high magnification shows tumor cells with the sharply defined cell borders, clear cytoplasm, and rounded nuclei
Mentions: Biopsy findings showed tumor cells with sharply defined cell borders, clear cytoplasm, and rounded nuclei consistent with an oligodendroglioma (Fig. 2). The pathologic specimens were negative for 1p or 19q chromosomal deletions. These findings were present when read at our institution as well as that of a large center where the tissue specimen were sent for histopathologic confirmation. The tissue did not stain with immunohistochemical stains for systemic cancers (such as cytokeratin).Fig. 2

Bottom Line: Primary leptomeningeal oligodendrogliomas (PLOs) are rare intracranial malignancies where tumors grow in the subarachnoid space without an obvious connection to the brain or spinal cord parenchyma.Adding to the three previously reported cases of PLO with no parenchymal involvement we report a fourth case of the same in this paper in a 50-year-old woman presenting with unrelenting headaches.Our case suggests that PLO can mimic diffuse forms of granulomatous meningitis and should be suspected in patients that clinically and radiographically present like granulomatous meningitis but without blood or CSF markers for the same.

View Article: PubMed Central - PubMed

Affiliation: Department of Neurological Surgery, State University New York at Buffalo, Buffalo, USA. mmathews@buffns.com

ABSTRACT
Primary leptomeningeal oligodendrogliomas (PLOs) are rare intracranial malignancies where tumors grow in the subarachnoid space without an obvious connection to the brain or spinal cord parenchyma. Adding to the three previously reported cases of PLO with no parenchymal involvement we report a fourth case of the same in this paper in a 50-year-old woman presenting with unrelenting headaches. CT scan of her head revealed hydrocephalus and MRI revealed diffuse enhancement of her leptomeninges throughout her brain and spine, prominent over the basilar region. Biopsy obtained using a frameless stereotactic biopsy showed sharply defined cell borders, clear cytoplasm, and rounded nuclei consistent with an oligodendroglioma. Our case suggests that PLO can mimic diffuse forms of granulomatous meningitis and should be suspected in patients that clinically and radiographically present like granulomatous meningitis but without blood or CSF markers for the same.

Show MeSH
Related in: MedlinePlus