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Primary ovarian leiomyoma associated with endometriotic cyst presenting with symptoms of acute appendicitis: a case report.

Tomas D, Lenicek T, Tuckar N, Puljiz Z, Ledinsky M, Kruslin B - Diagn Pathol (2009)

Bottom Line: Additionally, smooth muscle metaplasia of endometriotic stroma, smooth muscle present in mature cystic teratomas, and smooth muscle in the walls of mucinous cystic tumor may explain their occurrence in the ovary in some cases.A 31-year-old woman was admitted to our surgical emergency service with a one-day history of appendicitis-like symptoms.Appropriate diagnosis may require additional immunohistochemical analysis in some cases.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Sestre Milosrdnice University Hospital, Zagreb, Croatia. dtomas@kbsm.hr

ABSTRACT

Background: Ovarian leiomyoma is a rare benign tumor that accounts for 0.5 to 1% of all benign ovarian tumors. It probably arises from smooth muscle cells in the ovarian hilar blood vessels but there are other possible origins including cells in the ovarian ligament, smooth muscle cells or multipotential cells in the ovarian stroma, undifferentiated germ cells, or cortical smooth muscle metaplasia. Additionally, smooth muscle metaplasia of endometriotic stroma, smooth muscle present in mature cystic teratomas, and smooth muscle in the walls of mucinous cystic tumor may explain their occurrence in the ovary in some cases.

Case presentation: A 31-year-old woman was admitted to our surgical emergency service with a one-day history of appendicitis-like symptoms. Upon laparotomy, there was a solid, oval left-sided ovarian tumor located behind the uterus. The tumor was sent to the pathology department. A diagnosis of primary ovarian leiomyoma associated with an endometriotic cyst was established.

Conclusion: The origin of ovarian leiomyoma is still unresolved. In our case, the tumor probably arose from smooth muscle cells derived from myofibroblasts that originate from metaplastic ovarian stromal cells present in the rim of the endometriotic cyst. Despite its rarity, ovarian leiomyoma should be considered in the differential diagnosis of ovarian spindle cell tumors. Appropriate diagnosis may require additional immunohistochemical analysis in some cases.

No MeSH data available.


Related in: MedlinePlus

Grossly, the tumor was white-gray in color and the cut surface displayed a whorled pattern. On the pole beneath the salpinx there was a cyst measuring 3 cm in greatest diameter filled with brownish material that was included in the tumor (A). Microscopically, the tumor was composed of whorled interlacing fascicles of typical smooth muscle cells, and the lumen of the cyst was covered with cuboidal epithelial cells surrounded by endometrial-type stroma (B, 40×, H&E). Immunohistochemically, the tumor cells were positive for desmin (C, 100×) and α-smooth muscle actin (D, 100×).
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Figure 1: Grossly, the tumor was white-gray in color and the cut surface displayed a whorled pattern. On the pole beneath the salpinx there was a cyst measuring 3 cm in greatest diameter filled with brownish material that was included in the tumor (A). Microscopically, the tumor was composed of whorled interlacing fascicles of typical smooth muscle cells, and the lumen of the cyst was covered with cuboidal epithelial cells surrounded by endometrial-type stroma (B, 40×, H&E). Immunohistochemically, the tumor cells were positive for desmin (C, 100×) and α-smooth muscle actin (D, 100×).

Mentions: The tumor was firm, had a smooth and shiny surface and measured 11 × 10 × 6 cm. The cut surface of the tumor was white-gray in color and displayed a whorled pattern. On the pole beneath the salpinx there was a cyst measuring 3 cm in greatest diameter filled with brownish material that was included in the tumor (Fig. 1A). In the vicinity of the cyst, there were signs of hemorrhage and a thin, brownish, coarse layer of fibrin covered the tumor surface in this area. Grossly, there was no recognizable normal ovarian tissue. The left salpinx was unremarkable. The serosal surface of the appendix, which measured 4.5 × 1 cm, was opacified.


Primary ovarian leiomyoma associated with endometriotic cyst presenting with symptoms of acute appendicitis: a case report.

Tomas D, Lenicek T, Tuckar N, Puljiz Z, Ledinsky M, Kruslin B - Diagn Pathol (2009)

Grossly, the tumor was white-gray in color and the cut surface displayed a whorled pattern. On the pole beneath the salpinx there was a cyst measuring 3 cm in greatest diameter filled with brownish material that was included in the tumor (A). Microscopically, the tumor was composed of whorled interlacing fascicles of typical smooth muscle cells, and the lumen of the cyst was covered with cuboidal epithelial cells surrounded by endometrial-type stroma (B, 40×, H&E). Immunohistochemically, the tumor cells were positive for desmin (C, 100×) and α-smooth muscle actin (D, 100×).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2724421&req=5

Figure 1: Grossly, the tumor was white-gray in color and the cut surface displayed a whorled pattern. On the pole beneath the salpinx there was a cyst measuring 3 cm in greatest diameter filled with brownish material that was included in the tumor (A). Microscopically, the tumor was composed of whorled interlacing fascicles of typical smooth muscle cells, and the lumen of the cyst was covered with cuboidal epithelial cells surrounded by endometrial-type stroma (B, 40×, H&E). Immunohistochemically, the tumor cells were positive for desmin (C, 100×) and α-smooth muscle actin (D, 100×).
Mentions: The tumor was firm, had a smooth and shiny surface and measured 11 × 10 × 6 cm. The cut surface of the tumor was white-gray in color and displayed a whorled pattern. On the pole beneath the salpinx there was a cyst measuring 3 cm in greatest diameter filled with brownish material that was included in the tumor (Fig. 1A). In the vicinity of the cyst, there were signs of hemorrhage and a thin, brownish, coarse layer of fibrin covered the tumor surface in this area. Grossly, there was no recognizable normal ovarian tissue. The left salpinx was unremarkable. The serosal surface of the appendix, which measured 4.5 × 1 cm, was opacified.

Bottom Line: Additionally, smooth muscle metaplasia of endometriotic stroma, smooth muscle present in mature cystic teratomas, and smooth muscle in the walls of mucinous cystic tumor may explain their occurrence in the ovary in some cases.A 31-year-old woman was admitted to our surgical emergency service with a one-day history of appendicitis-like symptoms.Appropriate diagnosis may require additional immunohistochemical analysis in some cases.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, Sestre Milosrdnice University Hospital, Zagreb, Croatia. dtomas@kbsm.hr

ABSTRACT

Background: Ovarian leiomyoma is a rare benign tumor that accounts for 0.5 to 1% of all benign ovarian tumors. It probably arises from smooth muscle cells in the ovarian hilar blood vessels but there are other possible origins including cells in the ovarian ligament, smooth muscle cells or multipotential cells in the ovarian stroma, undifferentiated germ cells, or cortical smooth muscle metaplasia. Additionally, smooth muscle metaplasia of endometriotic stroma, smooth muscle present in mature cystic teratomas, and smooth muscle in the walls of mucinous cystic tumor may explain their occurrence in the ovary in some cases.

Case presentation: A 31-year-old woman was admitted to our surgical emergency service with a one-day history of appendicitis-like symptoms. Upon laparotomy, there was a solid, oval left-sided ovarian tumor located behind the uterus. The tumor was sent to the pathology department. A diagnosis of primary ovarian leiomyoma associated with an endometriotic cyst was established.

Conclusion: The origin of ovarian leiomyoma is still unresolved. In our case, the tumor probably arose from smooth muscle cells derived from myofibroblasts that originate from metaplastic ovarian stromal cells present in the rim of the endometriotic cyst. Despite its rarity, ovarian leiomyoma should be considered in the differential diagnosis of ovarian spindle cell tumors. Appropriate diagnosis may require additional immunohistochemical analysis in some cases.

No MeSH data available.


Related in: MedlinePlus