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Spectral domain optical coherence tomographic findings at convalescent stage of acute zonal occult outer retinopathy.

Ohta K, Sato A, Fukui E - Clin Ophthalmol (2009)

Bottom Line: In both cases, the anterior and posterior segments were almost normal, although both patients had a sudden unilateral vision decrease and photopsia.The retina in these areas was thinner due to a decrease in the thickness of both the outer nuclear layer (ONL) and inner nuclear layer (INL) in Case 2.The decrease in retinal thickness at the convalescent stage of AZOOR is most likely due to a shortening of not only the photoreceptors and ONL but also to a thinning of the INL in a severe case.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Matsumoto Dental University, shiojiri, Nagano, Japan.

ABSTRACT

Purpose: To describe the morphology of the retina at the convalescent stage of acute zonal occult outer retinopathy (AZOOR) from images obtained by spectral domain optical coherence tomography (SD-OCT).

Methods: The visual fields, electroretinograms (ERGs), and OCT images were reviewed in two women aged 24 and 33 years. The patients were followed for one and four years, respectively.

Results: In both cases, the anterior and posterior segments were almost normal, although both patients had a sudden unilateral vision decrease and photopsia. Goldmann perimetry revealed enlarged blind spots and scotomas. The ERGs were reduced in both cases. SD-OCT showed that the junction of the inner and outer segment, the IS/OS line, of the photoreceptors was irregular or lost in the affected retinas. The retina in these areas was thinner due to a decrease in the thickness of both the outer nuclear layer (ONL) and inner nuclear layer (INL) in Case 2.

Conclusions: The decrease in retinal thickness at the convalescent stage of AZOOR is most likely due to a shortening of not only the photoreceptors and ONL but also to a thinning of the INL in a severe case.

No MeSH data available.


Related in: MedlinePlus

Case 2 Findings in a 29-year-old woman with AZOOr at onset. A) Nearly normal fundus photograph of posterior pole of the left eye. B) Dense superior visual field defects. C) Topographic map of multifocal ERGs showing markedly reduced responses in the macular area. D) Time-domain optical coherence tomography image showing a reduction of the outer nuclear layer.Abbreviations: S, superior; I, inferior.
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f4-opth-3-423: Case 2 Findings in a 29-year-old woman with AZOOr at onset. A) Nearly normal fundus photograph of posterior pole of the left eye. B) Dense superior visual field defects. C) Topographic map of multifocal ERGs showing markedly reduced responses in the macular area. D) Time-domain optical coherence tomography image showing a reduction of the outer nuclear layer.Abbreviations: S, superior; I, inferior.

Mentions: A 29-year-old woman was referred complaining of a sudden blurring of vision with photopsia of two days duration in her left eye. Her BCVA was 1.5 OD and 0.2 OS, and her refractive errors were −9.0 Ds OU. The anterior segment and ophthalmoscopic findings appeared normal (Figure 4A) except for an old focal retinal detachment without macular involvement in the inferotemporal area of the left eye. A strongly pigmented demarcation line was seen peripheral to the vascular arcade but probably was not associated with the acute central visual field loss. A dense visual field defect was detected in the superior field (Figure 4B). Fluorescein angiography showed no leakage or delayed filling in the macular lesion. The multifocal ERGs recorded from the macular area of the left eye were reduced (Figure 4C). Time-domain OCT (OCT3000; Zeiss, Oberkochen, Germany) showed an irregularity or loss of the IS/OS line in the fovea and a reduction in the thickness of the outer nuclear layer (ONL) (Figure 4D). The brain MRI findings were normal. Although oral prednisone (30 mg/day) was administered, the BCVA and the VF defect were unchanged.


Spectral domain optical coherence tomographic findings at convalescent stage of acute zonal occult outer retinopathy.

Ohta K, Sato A, Fukui E - Clin Ophthalmol (2009)

Case 2 Findings in a 29-year-old woman with AZOOr at onset. A) Nearly normal fundus photograph of posterior pole of the left eye. B) Dense superior visual field defects. C) Topographic map of multifocal ERGs showing markedly reduced responses in the macular area. D) Time-domain optical coherence tomography image showing a reduction of the outer nuclear layer.Abbreviations: S, superior; I, inferior.
© Copyright Policy
Related In: Results  -  Collection

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getmorefigures.php?uid=PMC2724032&req=5

f4-opth-3-423: Case 2 Findings in a 29-year-old woman with AZOOr at onset. A) Nearly normal fundus photograph of posterior pole of the left eye. B) Dense superior visual field defects. C) Topographic map of multifocal ERGs showing markedly reduced responses in the macular area. D) Time-domain optical coherence tomography image showing a reduction of the outer nuclear layer.Abbreviations: S, superior; I, inferior.
Mentions: A 29-year-old woman was referred complaining of a sudden blurring of vision with photopsia of two days duration in her left eye. Her BCVA was 1.5 OD and 0.2 OS, and her refractive errors were −9.0 Ds OU. The anterior segment and ophthalmoscopic findings appeared normal (Figure 4A) except for an old focal retinal detachment without macular involvement in the inferotemporal area of the left eye. A strongly pigmented demarcation line was seen peripheral to the vascular arcade but probably was not associated with the acute central visual field loss. A dense visual field defect was detected in the superior field (Figure 4B). Fluorescein angiography showed no leakage or delayed filling in the macular lesion. The multifocal ERGs recorded from the macular area of the left eye were reduced (Figure 4C). Time-domain OCT (OCT3000; Zeiss, Oberkochen, Germany) showed an irregularity or loss of the IS/OS line in the fovea and a reduction in the thickness of the outer nuclear layer (ONL) (Figure 4D). The brain MRI findings were normal. Although oral prednisone (30 mg/day) was administered, the BCVA and the VF defect were unchanged.

Bottom Line: In both cases, the anterior and posterior segments were almost normal, although both patients had a sudden unilateral vision decrease and photopsia.The retina in these areas was thinner due to a decrease in the thickness of both the outer nuclear layer (ONL) and inner nuclear layer (INL) in Case 2.The decrease in retinal thickness at the convalescent stage of AZOOR is most likely due to a shortening of not only the photoreceptors and ONL but also to a thinning of the INL in a severe case.

View Article: PubMed Central - PubMed

Affiliation: Department of Ophthalmology, Matsumoto Dental University, shiojiri, Nagano, Japan.

ABSTRACT

Purpose: To describe the morphology of the retina at the convalescent stage of acute zonal occult outer retinopathy (AZOOR) from images obtained by spectral domain optical coherence tomography (SD-OCT).

Methods: The visual fields, electroretinograms (ERGs), and OCT images were reviewed in two women aged 24 and 33 years. The patients were followed for one and four years, respectively.

Results: In both cases, the anterior and posterior segments were almost normal, although both patients had a sudden unilateral vision decrease and photopsia. Goldmann perimetry revealed enlarged blind spots and scotomas. The ERGs were reduced in both cases. SD-OCT showed that the junction of the inner and outer segment, the IS/OS line, of the photoreceptors was irregular or lost in the affected retinas. The retina in these areas was thinner due to a decrease in the thickness of both the outer nuclear layer (ONL) and inner nuclear layer (INL) in Case 2.

Conclusions: The decrease in retinal thickness at the convalescent stage of AZOOR is most likely due to a shortening of not only the photoreceptors and ONL but also to a thinning of the INL in a severe case.

No MeSH data available.


Related in: MedlinePlus