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Adhesion molecule-modified biomaterials for neural tissue engineering.

Rao SS, Winter JO - Front Neuroeng (2009)

Bottom Line: These tethered molecules provide cues to regenerating neurons that recapitulate the native brain environment.Improving cell adhesive potential of non-adhesive biomaterials is therefore a common goal in neural tissue engineering.Additionally, patterning of AMs for achieving specific neuronal responses is explored.

View Article: PubMed Central - PubMed

Affiliation: William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University Columbus, OH, USA.

ABSTRACT
Adhesion molecules (AMs) represent one class of biomolecules that promote central nervous system regeneration. These tethered molecules provide cues to regenerating neurons that recapitulate the native brain environment. Improving cell adhesive potential of non-adhesive biomaterials is therefore a common goal in neural tissue engineering. This review discusses common AMs used in neural biomaterials and the mechanism of cell attachment to these AMs. Methods to modify materials with AMs are discussed and compared. Additionally, patterning of AMs for achieving specific neuronal responses is explored.

No MeSH data available.


Related in: MedlinePlus

Adapted from (Hermanson, 1996).
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S5: Adapted from (Hermanson, 1996).

Mentions: Perhaps the most popular method used for covalent biomaterial modification is EDC chemistry, which proceeds via reaction with carboxylate (–COOH) groups. EDC or EDAC [1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride] is a water soluble, zero length cross linker. Generally, EDC is used to covalently link a carboxylate (–COOH) or a phosphate (–PO4) compound with an amine (–NH2) (Scheme 5).


Adhesion molecule-modified biomaterials for neural tissue engineering.

Rao SS, Winter JO - Front Neuroeng (2009)

Adapted from (Hermanson, 1996).
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2723915&req=5

S5: Adapted from (Hermanson, 1996).
Mentions: Perhaps the most popular method used for covalent biomaterial modification is EDC chemistry, which proceeds via reaction with carboxylate (–COOH) groups. EDC or EDAC [1-ethyl-3-(3-dimethylaminopropyl) carbodiimide hydrochloride] is a water soluble, zero length cross linker. Generally, EDC is used to covalently link a carboxylate (–COOH) or a phosphate (–PO4) compound with an amine (–NH2) (Scheme 5).

Bottom Line: These tethered molecules provide cues to regenerating neurons that recapitulate the native brain environment.Improving cell adhesive potential of non-adhesive biomaterials is therefore a common goal in neural tissue engineering.Additionally, patterning of AMs for achieving specific neuronal responses is explored.

View Article: PubMed Central - PubMed

Affiliation: William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University Columbus, OH, USA.

ABSTRACT
Adhesion molecules (AMs) represent one class of biomolecules that promote central nervous system regeneration. These tethered molecules provide cues to regenerating neurons that recapitulate the native brain environment. Improving cell adhesive potential of non-adhesive biomaterials is therefore a common goal in neural tissue engineering. This review discusses common AMs used in neural biomaterials and the mechanism of cell attachment to these AMs. Methods to modify materials with AMs are discussed and compared. Additionally, patterning of AMs for achieving specific neuronal responses is explored.

No MeSH data available.


Related in: MedlinePlus