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Adhesion molecule-modified biomaterials for neural tissue engineering.

Rao SS, Winter JO - Front Neuroeng (2009)

Bottom Line: These tethered molecules provide cues to regenerating neurons that recapitulate the native brain environment.Improving cell adhesive potential of non-adhesive biomaterials is therefore a common goal in neural tissue engineering.Additionally, patterning of AMs for achieving specific neuronal responses is explored.

View Article: PubMed Central - PubMed

Affiliation: William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University Columbus, OH, USA.

ABSTRACT
Adhesion molecules (AMs) represent one class of biomolecules that promote central nervous system regeneration. These tethered molecules provide cues to regenerating neurons that recapitulate the native brain environment. Improving cell adhesive potential of non-adhesive biomaterials is therefore a common goal in neural tissue engineering. This review discusses common AMs used in neural biomaterials and the mechanism of cell attachment to these AMs. Methods to modify materials with AMs are discussed and compared. Additionally, patterning of AMs for achieving specific neuronal responses is explored.

No MeSH data available.


Related in: MedlinePlus

Neuroblastoma cell response on a coated neural probe (Cui et al., 2001). Reprinted with permission of John Wiley & Sons, Inc. © 2001 John Wiley & Sons, Inc.
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Figure 7: Neuroblastoma cell response on a coated neural probe (Cui et al., 2001). Reprinted with permission of John Wiley & Sons, Inc. © 2001 John Wiley & Sons, Inc.

Mentions: This method has been used to dope polypyrrole with CDPGYIGSR (Figure 6), an extended peptide sequence from laminin, on gold recording sites of Si-neural recording probes (Cui et al., 2001). In vitro, these materials demonstrated increased neuroblastoma cell adhesion compared to control films (Figure 7). In vivo, the coatings have been shown to be stable for at least 1 week and to promote neural adhesion (Cui et al., 2003). In later work, PPy/RNIAEIIKDI (a sequence from laminin) coatings were shown to be superior to the original PPy/CDPGYIGSR composites in promoting neural adhesion and axonal growth (Stauffer and Cui, 2006), demonstrating the importance of AM selection when creating modified biomaterials. This work has also been extended to other conducting polymers, for example poly(hydroxymethylated-3, 4-ethlenedioxythiophene) (PEDOT-MeOH) has been doped with the laminin fragment CDPGYIGSR (Xiao et al., 2006).


Adhesion molecule-modified biomaterials for neural tissue engineering.

Rao SS, Winter JO - Front Neuroeng (2009)

Neuroblastoma cell response on a coated neural probe (Cui et al., 2001). Reprinted with permission of John Wiley & Sons, Inc. © 2001 John Wiley & Sons, Inc.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2723915&req=5

Figure 7: Neuroblastoma cell response on a coated neural probe (Cui et al., 2001). Reprinted with permission of John Wiley & Sons, Inc. © 2001 John Wiley & Sons, Inc.
Mentions: This method has been used to dope polypyrrole with CDPGYIGSR (Figure 6), an extended peptide sequence from laminin, on gold recording sites of Si-neural recording probes (Cui et al., 2001). In vitro, these materials demonstrated increased neuroblastoma cell adhesion compared to control films (Figure 7). In vivo, the coatings have been shown to be stable for at least 1 week and to promote neural adhesion (Cui et al., 2003). In later work, PPy/RNIAEIIKDI (a sequence from laminin) coatings were shown to be superior to the original PPy/CDPGYIGSR composites in promoting neural adhesion and axonal growth (Stauffer and Cui, 2006), demonstrating the importance of AM selection when creating modified biomaterials. This work has also been extended to other conducting polymers, for example poly(hydroxymethylated-3, 4-ethlenedioxythiophene) (PEDOT-MeOH) has been doped with the laminin fragment CDPGYIGSR (Xiao et al., 2006).

Bottom Line: These tethered molecules provide cues to regenerating neurons that recapitulate the native brain environment.Improving cell adhesive potential of non-adhesive biomaterials is therefore a common goal in neural tissue engineering.Additionally, patterning of AMs for achieving specific neuronal responses is explored.

View Article: PubMed Central - PubMed

Affiliation: William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University Columbus, OH, USA.

ABSTRACT
Adhesion molecules (AMs) represent one class of biomolecules that promote central nervous system regeneration. These tethered molecules provide cues to regenerating neurons that recapitulate the native brain environment. Improving cell adhesive potential of non-adhesive biomaterials is therefore a common goal in neural tissue engineering. This review discusses common AMs used in neural biomaterials and the mechanism of cell attachment to these AMs. Methods to modify materials with AMs are discussed and compared. Additionally, patterning of AMs for achieving specific neuronal responses is explored.

No MeSH data available.


Related in: MedlinePlus