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Evaluation of the Wound-healing Activity of Ethanolic Extract of Morinda citrifolia L. Leaf.

Nayak BS, Sandiford S, Maxwell A - Evid Based Complement Alternat Med (2007)

Bottom Line: The primary indigenous use of this plant appears to be of the leaves, as a topical treatment for wound healing.On day 11, the extract-treated animals exhibited 71% reduction in the wound area when compared with controls which exhibited 57%.The granulation tissue weight and hydroxyproline content in the dead space wounds were also increased significantly in noni-treated animals compared with controls (P < 0.002).

View Article: PubMed Central - PubMed

Affiliation: Department of Pre clinical Sciences, Biochemistry unit, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad. shiv25@gmail.com.

ABSTRACT
Morinda citrifolia L. (noni) is one of the most important traditional Polynesian medicinal plants. The primary indigenous use of this plant appears to be of the leaves, as a topical treatment for wound healing. The ethanol extract of noni leaves (150 mg kg(-1) day(-1)) was used to evaluate the wound-healing activity on rats, using excision and dead space wound models. Animals were randomly divided into two groups of six for each model. Test group animals in each model were treated with the ethanol extract of noni orally by mixing in drinking water and the control group animals were maintained with plain drinking water. Healing was assessed by the rate of wound contraction, time until complete epithelialization, granulation tissue weight and hydoxyproline content. On day 11, the extract-treated animals exhibited 71% reduction in the wound area when compared with controls which exhibited 57%. The granulation tissue weight and hydroxyproline content in the dead space wounds were also increased significantly in noni-treated animals compared with controls (P < 0.002). Enhanced wound contraction, decreased epithelialization time, increased hydroxyproline content and histological characteristics suggest that noni leaf extract may have therapeutic benefits in wound healing.

No MeSH data available.


Related in: MedlinePlus

The schematic diagram showing the possible effect of the M. citrifolia leaf extract in promoting wound-healing activity.
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Figure 6: The schematic diagram showing the possible effect of the M. citrifolia leaf extract in promoting wound-healing activity.

Mentions: In our study, the ethanol extract of noni significantly increased the rate of wound contraction, the rate of epithelialization and weight of the granulation tissue. Granulation tissue formed in the final part of the proliferative phase is primarily composed of fibroblasts, collagen, edema and new small blood vessels. The increase in dry granulation tissue content of wounds in extract treated animals suggests higher collagen content. The constituents present in the noni extract may be responsible for promoting the collagen formation at the proliferative stage of wound healing (Fig. 6).Figure 6.


Evaluation of the Wound-healing Activity of Ethanolic Extract of Morinda citrifolia L. Leaf.

Nayak BS, Sandiford S, Maxwell A - Evid Based Complement Alternat Med (2007)

The schematic diagram showing the possible effect of the M. citrifolia leaf extract in promoting wound-healing activity.
© Copyright Policy - creative-commons
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2722214&req=5

Figure 6: The schematic diagram showing the possible effect of the M. citrifolia leaf extract in promoting wound-healing activity.
Mentions: In our study, the ethanol extract of noni significantly increased the rate of wound contraction, the rate of epithelialization and weight of the granulation tissue. Granulation tissue formed in the final part of the proliferative phase is primarily composed of fibroblasts, collagen, edema and new small blood vessels. The increase in dry granulation tissue content of wounds in extract treated animals suggests higher collagen content. The constituents present in the noni extract may be responsible for promoting the collagen formation at the proliferative stage of wound healing (Fig. 6).Figure 6.

Bottom Line: The primary indigenous use of this plant appears to be of the leaves, as a topical treatment for wound healing.On day 11, the extract-treated animals exhibited 71% reduction in the wound area when compared with controls which exhibited 57%.The granulation tissue weight and hydroxyproline content in the dead space wounds were also increased significantly in noni-treated animals compared with controls (P < 0.002).

View Article: PubMed Central - PubMed

Affiliation: Department of Pre clinical Sciences, Biochemistry unit, Faculty of Medical Sciences, The University of the West Indies, St Augustine, Trinidad. shiv25@gmail.com.

ABSTRACT
Morinda citrifolia L. (noni) is one of the most important traditional Polynesian medicinal plants. The primary indigenous use of this plant appears to be of the leaves, as a topical treatment for wound healing. The ethanol extract of noni leaves (150 mg kg(-1) day(-1)) was used to evaluate the wound-healing activity on rats, using excision and dead space wound models. Animals were randomly divided into two groups of six for each model. Test group animals in each model were treated with the ethanol extract of noni orally by mixing in drinking water and the control group animals were maintained with plain drinking water. Healing was assessed by the rate of wound contraction, time until complete epithelialization, granulation tissue weight and hydoxyproline content. On day 11, the extract-treated animals exhibited 71% reduction in the wound area when compared with controls which exhibited 57%. The granulation tissue weight and hydroxyproline content in the dead space wounds were also increased significantly in noni-treated animals compared with controls (P < 0.002). Enhanced wound contraction, decreased epithelialization time, increased hydroxyproline content and histological characteristics suggest that noni leaf extract may have therapeutic benefits in wound healing.

No MeSH data available.


Related in: MedlinePlus