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Protective effects of Salvia miltiorrhizae on multiple organs of rats with obstructive jaundice.

Ling Z, Xiping Z, Fengmei Q, Ping Y, Qihui C - Mediators Inflamm. (2009)

Bottom Line: The pathological alterations in the liver, kidney, and spleen in treated group showed varying degrees of mitigation.At all time points, the contents of plasma endotoxin declined significantly.On day 28, plasma PLA(2) content in treated group was significantly lower than that in model-control group.

View Article: PubMed Central - PubMed

Affiliation: The Cardiovascular Research Laboratory, Lakehead University, 290 Munro Street, Thunder Bay, ON, Canada P7A 7 T1.

ABSTRACT

Purpose: we aim to explore the protective effects of Salvia miltiorrhizae injection on multiple organs of obstructive jaundice (OJ) rats through observing the impact of this injection on the pathological alterations in these organs and the contents of endotoxin, PLA(2), and TNF-alpha in the blood.

Methods: A total of 90 mice were randomly divided into sham-operated group, model-control group, and Salvia miltiorrhizae-treated group (n = 30). According to the duration of postoperative administration, each group was further divided into two subgroups, namely, 21 d subgroup (consecutive administration for 21 d, n = 15) and 28 d subgroup (consecutive administration for 28 d, n = 15). After administration, the pathological alterations in multiple organs were observed and the contents of endotoxin, PLA(2), and TNF-alpha in the blood were determined.

Results: Compared to model control group, the number of dead rats in treated group decreased though there was no statistical difference between the two groups. The pathological alterations in the liver, kidney, and spleen in treated group showed varying degrees of mitigation. At all time points, the contents of plasma endotoxin declined significantly. On day 28, plasma PLA(2) content in treated group was significantly lower than that in model-control group.

Conclusion: Salvia miltiorrhizae injection is able to obviously reduce the contents of inflammatory mediators in the blood of OJ rats and exert some protective effects on multiple organs of these rats.

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Related in: MedlinePlus

Treated group 28 days; capillary distension and congestion in the alveolar wall as well as inflammatory cell infiltration in the alveolar septum; HE × 400.
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fig8: Treated group 28 days; capillary distension and congestion in the alveolar wall as well as inflammatory cell infiltration in the alveolar septum; HE × 400.

Mentions: On day 21, the lung of the majority of rats showed edema in the alveolar wall and inflammatory cell infiltration in the interstitium. The lung of some rats showed hyperplasia and widening of the alveolar wall as well as vascular distention. The lung of individual rats was normal. On day 28, the lung of the majority of rats showed edema and inflammatory cell infiltration in the interstitium and alveolar wall as well as hyperplasia and widening of interstitial fiber while the lung of individual rats was normal. Overall, the pathological alterations in treated group were milder than those in model-control group, see Figure 8.


Protective effects of Salvia miltiorrhizae on multiple organs of rats with obstructive jaundice.

Ling Z, Xiping Z, Fengmei Q, Ping Y, Qihui C - Mediators Inflamm. (2009)

Treated group 28 days; capillary distension and congestion in the alveolar wall as well as inflammatory cell infiltration in the alveolar septum; HE × 400.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2722062&req=5

fig8: Treated group 28 days; capillary distension and congestion in the alveolar wall as well as inflammatory cell infiltration in the alveolar septum; HE × 400.
Mentions: On day 21, the lung of the majority of rats showed edema in the alveolar wall and inflammatory cell infiltration in the interstitium. The lung of some rats showed hyperplasia and widening of the alveolar wall as well as vascular distention. The lung of individual rats was normal. On day 28, the lung of the majority of rats showed edema and inflammatory cell infiltration in the interstitium and alveolar wall as well as hyperplasia and widening of interstitial fiber while the lung of individual rats was normal. Overall, the pathological alterations in treated group were milder than those in model-control group, see Figure 8.

Bottom Line: The pathological alterations in the liver, kidney, and spleen in treated group showed varying degrees of mitigation.At all time points, the contents of plasma endotoxin declined significantly.On day 28, plasma PLA(2) content in treated group was significantly lower than that in model-control group.

View Article: PubMed Central - PubMed

Affiliation: The Cardiovascular Research Laboratory, Lakehead University, 290 Munro Street, Thunder Bay, ON, Canada P7A 7 T1.

ABSTRACT

Purpose: we aim to explore the protective effects of Salvia miltiorrhizae injection on multiple organs of obstructive jaundice (OJ) rats through observing the impact of this injection on the pathological alterations in these organs and the contents of endotoxin, PLA(2), and TNF-alpha in the blood.

Methods: A total of 90 mice were randomly divided into sham-operated group, model-control group, and Salvia miltiorrhizae-treated group (n = 30). According to the duration of postoperative administration, each group was further divided into two subgroups, namely, 21 d subgroup (consecutive administration for 21 d, n = 15) and 28 d subgroup (consecutive administration for 28 d, n = 15). After administration, the pathological alterations in multiple organs were observed and the contents of endotoxin, PLA(2), and TNF-alpha in the blood were determined.

Results: Compared to model control group, the number of dead rats in treated group decreased though there was no statistical difference between the two groups. The pathological alterations in the liver, kidney, and spleen in treated group showed varying degrees of mitigation. At all time points, the contents of plasma endotoxin declined significantly. On day 28, plasma PLA(2) content in treated group was significantly lower than that in model-control group.

Conclusion: Salvia miltiorrhizae injection is able to obviously reduce the contents of inflammatory mediators in the blood of OJ rats and exert some protective effects on multiple organs of these rats.

Show MeSH
Related in: MedlinePlus