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Protective effects of Salvia miltiorrhizae on multiple organs of rats with obstructive jaundice.

Ling Z, Xiping Z, Fengmei Q, Ping Y, Qihui C - Mediators Inflamm. (2009)

Bottom Line: The pathological alterations in the liver, kidney, and spleen in treated group showed varying degrees of mitigation.At all time points, the contents of plasma endotoxin declined significantly.On day 28, plasma PLA(2) content in treated group was significantly lower than that in model-control group.

View Article: PubMed Central - PubMed

Affiliation: The Cardiovascular Research Laboratory, Lakehead University, 290 Munro Street, Thunder Bay, ON, Canada P7A 7 T1.

ABSTRACT

Purpose: we aim to explore the protective effects of Salvia miltiorrhizae injection on multiple organs of obstructive jaundice (OJ) rats through observing the impact of this injection on the pathological alterations in these organs and the contents of endotoxin, PLA(2), and TNF-alpha in the blood.

Methods: A total of 90 mice were randomly divided into sham-operated group, model-control group, and Salvia miltiorrhizae-treated group (n = 30). According to the duration of postoperative administration, each group was further divided into two subgroups, namely, 21 d subgroup (consecutive administration for 21 d, n = 15) and 28 d subgroup (consecutive administration for 28 d, n = 15). After administration, the pathological alterations in multiple organs were observed and the contents of endotoxin, PLA(2), and TNF-alpha in the blood were determined.

Results: Compared to model control group, the number of dead rats in treated group decreased though there was no statistical difference between the two groups. The pathological alterations in the liver, kidney, and spleen in treated group showed varying degrees of mitigation. At all time points, the contents of plasma endotoxin declined significantly. On day 28, plasma PLA(2) content in treated group was significantly lower than that in model-control group.

Conclusion: Salvia miltiorrhizae injection is able to obviously reduce the contents of inflammatory mediators in the blood of OJ rats and exert some protective effects on multiple organs of these rats.

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Related in: MedlinePlus

Model-control group 21 days; degeneration and swelling of hepatic cells as well as hyperplasia of bile ducts; HE × 200.
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fig2: Model-control group 21 days; degeneration and swelling of hepatic cells as well as hyperplasia of bile ducts; HE × 200.

Mentions: There were aggravated with the increase of postoperative duration. These pathological changes mainly manifested as swelling and obscure boundary in the majority of hepatic cells, the narrowing or partial disappearance of some hepatic sinusoids, as well as vascuolation and dissolution of hepatic cells in occasional part of the liver. The number of apoptotic bodies increased. The connective tissue in the most part of the portal area showed stellated hyperplasia. The bile ducts, whose surroundings revealed acute and chronic inflammatory cell infiltration, were enlarged and hyperproliferated. The limiting plate of hepatocytes were destroyed and showed focal necrosis, see Figures 2 and 3.


Protective effects of Salvia miltiorrhizae on multiple organs of rats with obstructive jaundice.

Ling Z, Xiping Z, Fengmei Q, Ping Y, Qihui C - Mediators Inflamm. (2009)

Model-control group 21 days; degeneration and swelling of hepatic cells as well as hyperplasia of bile ducts; HE × 200.
© Copyright Policy - open-access
Related In: Results  -  Collection

Show All Figures
getmorefigures.php?uid=PMC2722062&req=5

fig2: Model-control group 21 days; degeneration and swelling of hepatic cells as well as hyperplasia of bile ducts; HE × 200.
Mentions: There were aggravated with the increase of postoperative duration. These pathological changes mainly manifested as swelling and obscure boundary in the majority of hepatic cells, the narrowing or partial disappearance of some hepatic sinusoids, as well as vascuolation and dissolution of hepatic cells in occasional part of the liver. The number of apoptotic bodies increased. The connective tissue in the most part of the portal area showed stellated hyperplasia. The bile ducts, whose surroundings revealed acute and chronic inflammatory cell infiltration, were enlarged and hyperproliferated. The limiting plate of hepatocytes were destroyed and showed focal necrosis, see Figures 2 and 3.

Bottom Line: The pathological alterations in the liver, kidney, and spleen in treated group showed varying degrees of mitigation.At all time points, the contents of plasma endotoxin declined significantly.On day 28, plasma PLA(2) content in treated group was significantly lower than that in model-control group.

View Article: PubMed Central - PubMed

Affiliation: The Cardiovascular Research Laboratory, Lakehead University, 290 Munro Street, Thunder Bay, ON, Canada P7A 7 T1.

ABSTRACT

Purpose: we aim to explore the protective effects of Salvia miltiorrhizae injection on multiple organs of obstructive jaundice (OJ) rats through observing the impact of this injection on the pathological alterations in these organs and the contents of endotoxin, PLA(2), and TNF-alpha in the blood.

Methods: A total of 90 mice were randomly divided into sham-operated group, model-control group, and Salvia miltiorrhizae-treated group (n = 30). According to the duration of postoperative administration, each group was further divided into two subgroups, namely, 21 d subgroup (consecutive administration for 21 d, n = 15) and 28 d subgroup (consecutive administration for 28 d, n = 15). After administration, the pathological alterations in multiple organs were observed and the contents of endotoxin, PLA(2), and TNF-alpha in the blood were determined.

Results: Compared to model control group, the number of dead rats in treated group decreased though there was no statistical difference between the two groups. The pathological alterations in the liver, kidney, and spleen in treated group showed varying degrees of mitigation. At all time points, the contents of plasma endotoxin declined significantly. On day 28, plasma PLA(2) content in treated group was significantly lower than that in model-control group.

Conclusion: Salvia miltiorrhizae injection is able to obviously reduce the contents of inflammatory mediators in the blood of OJ rats and exert some protective effects on multiple organs of these rats.

Show MeSH
Related in: MedlinePlus