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Primary non-Hodgkin lymphoma of liver.

Masood A, Kairouz S, Hudhud KH, Hegazi AZ, Banu A, Gupta NC - Curr Oncol (2009)

Bottom Line: The patient is currently being treated with a CHOP-R (cyclophosphamide-doxorubicin-vincristine-prednisolone/rituximab) regimen.The case has many unique features, including normal liver function tests, especially that for lactate dehydrogenase; no type B symptoms; and negative serology for viruses.The case demonstrates that primary hepatic lymphoma should be considered in the differential diagnosis of space-occupying liver lesions in presence of normal levels of alpha-fetoprotein and carcinoembryonic antigen.

View Article: PubMed Central - PubMed

Affiliation: Cancer Care Center of Frederick, 46B Thomas Johnson Drive, Frederick, Maryland, 21702, USA. ashiqmsd@gmail.com

ABSTRACT
Primary non-Hodgkin lymphoma (NHL) of liver is a very rare malignancy. Here, we report the case of a 65-year-old man who presented with constipation and right groin pain of 2 months' duration. A computed tomography (CT) scan of the abdomen incidentally detected multiple hypodense nodules in both lobes of the liver. Diagnosis of primary NHL of liver was made using ultrasound-guided biopsy. Extensive investigations--which included bone marrow biopsy; fluorescence in situ hybridization; flow cytometry; CT scan of chest, abdomen, and pelvis; and whole-body positron-emission tomography--showed no involvement of bone marrow, lymph nodes, spleen, or any other organ. The patient is currently being treated with a CHOP-R (cyclophosphamide-doxorubicin-vincristine-prednisolone/rituximab) regimen. The case has many unique features, including normal liver function tests, especially that for lactate dehydrogenase; no type B symptoms; and negative serology for viruses. The case demonstrates that primary hepatic lymphoma should be considered in the differential diagnosis of space-occupying liver lesions in presence of normal levels of alpha-fetoprotein and carcinoembryonic antigen. The literature is extensively reviewed.

No MeSH data available.


Related in: MedlinePlus

A photomicrograph shows tumour cells positive for CD45.
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f6-co16-4-74: A photomicrograph shows tumour cells positive for CD45.

Mentions: Histologic analysis after ultrasound-guided biopsy of the lesion showed diffuse infiltrates and small-to-intermediate atypical cells consistent with lymphoma (Figure 4). Immunostaining of the tumour cells showed reactivity for CD20, CD5, CD45, and Bcl6 (Figures 5 and 6).


Primary non-Hodgkin lymphoma of liver.

Masood A, Kairouz S, Hudhud KH, Hegazi AZ, Banu A, Gupta NC - Curr Oncol (2009)

A photomicrograph shows tumour cells positive for CD45.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2722057&req=5

f6-co16-4-74: A photomicrograph shows tumour cells positive for CD45.
Mentions: Histologic analysis after ultrasound-guided biopsy of the lesion showed diffuse infiltrates and small-to-intermediate atypical cells consistent with lymphoma (Figure 4). Immunostaining of the tumour cells showed reactivity for CD20, CD5, CD45, and Bcl6 (Figures 5 and 6).

Bottom Line: The patient is currently being treated with a CHOP-R (cyclophosphamide-doxorubicin-vincristine-prednisolone/rituximab) regimen.The case has many unique features, including normal liver function tests, especially that for lactate dehydrogenase; no type B symptoms; and negative serology for viruses.The case demonstrates that primary hepatic lymphoma should be considered in the differential diagnosis of space-occupying liver lesions in presence of normal levels of alpha-fetoprotein and carcinoembryonic antigen.

View Article: PubMed Central - PubMed

Affiliation: Cancer Care Center of Frederick, 46B Thomas Johnson Drive, Frederick, Maryland, 21702, USA. ashiqmsd@gmail.com

ABSTRACT
Primary non-Hodgkin lymphoma (NHL) of liver is a very rare malignancy. Here, we report the case of a 65-year-old man who presented with constipation and right groin pain of 2 months' duration. A computed tomography (CT) scan of the abdomen incidentally detected multiple hypodense nodules in both lobes of the liver. Diagnosis of primary NHL of liver was made using ultrasound-guided biopsy. Extensive investigations--which included bone marrow biopsy; fluorescence in situ hybridization; flow cytometry; CT scan of chest, abdomen, and pelvis; and whole-body positron-emission tomography--showed no involvement of bone marrow, lymph nodes, spleen, or any other organ. The patient is currently being treated with a CHOP-R (cyclophosphamide-doxorubicin-vincristine-prednisolone/rituximab) regimen. The case has many unique features, including normal liver function tests, especially that for lactate dehydrogenase; no type B symptoms; and negative serology for viruses. The case demonstrates that primary hepatic lymphoma should be considered in the differential diagnosis of space-occupying liver lesions in presence of normal levels of alpha-fetoprotein and carcinoembryonic antigen. The literature is extensively reviewed.

No MeSH data available.


Related in: MedlinePlus