Limits...
Sentinel lymph node radiolocalization with 99mTc filtered tin colloid in clinically node-negative squamous cell carcinomas of the oral cavity.

Jeong HS, Baek CH, Son YI, Cho DY, Chung MK, Min JY, Ko YH, Kim BT - J. Korean Med. Sci. (2006)

Bottom Line: In all cases, the status of the sentinel node accurately predicted the pathologic status of the neck with the false negative rate being 0%.The negative predictive value for the absence of cervical metastases was 100%.In conclusion, our radiolocalization technique of sentinel nodes using 99mTc filtered tin colloid in N0 squamous cell carcinomas of the oral cavity is technically feasible and appears to accurately predict the presence of the occult metastatic disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
The objective of this study was to evaluate the feasibility of sentinel lymph node biopsy by using a radiotracer lymphatic mapping technique in patients with squamous cell carcinoma of the oral cavity, and the diagnostic value of this technique. We studied twenty patients with previously untreated squamous cell carcinomas of the oral cavity and N0 necks. After the peritumoral injection of 99mTc filtered tin colloid preoperatively, lymphoscintigraphy and intraoperative mapping using a gamma detector were performed to localize sentinel nodes. An open biopsy of the sentinel node was followed by complete neck dissection. We identified the sentinel nodes in 19 of 20 patients (95.0%) by lymphoscintigraphy and in all (100%) by intraoperative gamma detector. In all cases, the status of the sentinel node accurately predicted the pathologic status of the neck with the false negative rate being 0%. The negative predictive value for the absence of cervical metastases was 100%. In conclusion, our radiolocalization technique of sentinel nodes using 99mTc filtered tin colloid in N0 squamous cell carcinomas of the oral cavity is technically feasible and appears to accurately predict the presence of the occult metastatic disease.

Show MeSH

Related in: MedlinePlus

Confirmation of the radioactivity of sentinel nodes ex vivo. Sentinel nodes were labeled according to their radioactivity after the radioactivity within the node was confirmed ex vivo.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2721997&req=5

Figure 5: Confirmation of the radioactivity of sentinel nodes ex vivo. Sentinel nodes were labeled according to their radioactivity after the radioactivity within the node was confirmed ex vivo.

Mentions: Sentinel nodes were labeled according to their radioactivity and anatomic lymph node level after the radioactivity within the node was confirmed ex vivo (Fig. 5). The sentinel nodes were divided into three equal levels through their longest axis and frozen with Optimal Cutting Temperature compound separately. One section for each block was evaluated using frozen section analysis with hematoxylin-eosin staining.


Sentinel lymph node radiolocalization with 99mTc filtered tin colloid in clinically node-negative squamous cell carcinomas of the oral cavity.

Jeong HS, Baek CH, Son YI, Cho DY, Chung MK, Min JY, Ko YH, Kim BT - J. Korean Med. Sci. (2006)

Confirmation of the radioactivity of sentinel nodes ex vivo. Sentinel nodes were labeled according to their radioactivity after the radioactivity within the node was confirmed ex vivo.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2721997&req=5

Figure 5: Confirmation of the radioactivity of sentinel nodes ex vivo. Sentinel nodes were labeled according to their radioactivity after the radioactivity within the node was confirmed ex vivo.
Mentions: Sentinel nodes were labeled according to their radioactivity and anatomic lymph node level after the radioactivity within the node was confirmed ex vivo (Fig. 5). The sentinel nodes were divided into three equal levels through their longest axis and frozen with Optimal Cutting Temperature compound separately. One section for each block was evaluated using frozen section analysis with hematoxylin-eosin staining.

Bottom Line: In all cases, the status of the sentinel node accurately predicted the pathologic status of the neck with the false negative rate being 0%.The negative predictive value for the absence of cervical metastases was 100%.In conclusion, our radiolocalization technique of sentinel nodes using 99mTc filtered tin colloid in N0 squamous cell carcinomas of the oral cavity is technically feasible and appears to accurately predict the presence of the occult metastatic disease.

View Article: PubMed Central - PubMed

Affiliation: Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.

ABSTRACT
The objective of this study was to evaluate the feasibility of sentinel lymph node biopsy by using a radiotracer lymphatic mapping technique in patients with squamous cell carcinoma of the oral cavity, and the diagnostic value of this technique. We studied twenty patients with previously untreated squamous cell carcinomas of the oral cavity and N0 necks. After the peritumoral injection of 99mTc filtered tin colloid preoperatively, lymphoscintigraphy and intraoperative mapping using a gamma detector were performed to localize sentinel nodes. An open biopsy of the sentinel node was followed by complete neck dissection. We identified the sentinel nodes in 19 of 20 patients (95.0%) by lymphoscintigraphy and in all (100%) by intraoperative gamma detector. In all cases, the status of the sentinel node accurately predicted the pathologic status of the neck with the false negative rate being 0%. The negative predictive value for the absence of cervical metastases was 100%. In conclusion, our radiolocalization technique of sentinel nodes using 99mTc filtered tin colloid in N0 squamous cell carcinomas of the oral cavity is technically feasible and appears to accurately predict the presence of the occult metastatic disease.

Show MeSH
Related in: MedlinePlus