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Changes of serum cytokines after the long term immunotherapy with Japanese hop pollen extracts.

Ye YM, Lee SK, Kim SH, Nahm DH, Suh CH, Park HS - J. Korean Med. Sci. (2006)

Bottom Line: Skin reactivity and airway hyper-responsiveness to methacholine were improved during the study period.Specific IgG1 increased at 1 yr then decreased again at 3 yr, and specific IgG4 levels increased progressively (p<0.05, respectively), whereas total and specific IgE levels showed variable responses with no statistical significance.IL-10, TGF-beta1 and soluble CD23 level began to decrease during first year and then further decreased during next two years with statistical significances. (p<0.05, respectively).

View Article: PubMed Central - PubMed

Affiliation: Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea.

ABSTRACT
Japanese hop (Hop J) pollen has been considered as one of the major causative pollen allergens in the autumn season. We developed a new Hop J immunotherapy extract in collaboration with Allergopharma (Reinbeck, Germany) and investigated immunologic mechanisms during 3 yr immunotherapy. Twenty patients (13 asthma with rhinitis and 7 hay fever) were enrolled from Ajou University Hospital. Sera were collected before, 1 yr, and 3 yr after the immunotherapy. Changes of serum specific IgE, IgG1, and IgG4 levels to Hop J pollen extracts and serum IL-10, IL-12, TGF-beta1 and soluble CD23 levels were monitored by ELISA. Skin reactivity and airway hyper-responsiveness to methacholine were improved during the study period. Specific IgG1 increased at 1 yr then decreased again at 3 yr, and specific IgG4 levels increased progressively (p<0.05, respectively), whereas total and specific IgE levels showed variable responses with no statistical significance. IL-10, TGF-beta1 and soluble CD23 level began to decrease during first year and then further decreased during next two years with statistical significances. (p<0.05, respectively). In conclusion, these findings suggested the favorable effect of long term immunotherapy with Hop J pollen extracts can be explained by lowered IgE affinity and generation of specific IgG4, which may be mediated by IL-10 and TGF-beta1.

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Changes of serum specific IgE (A) and sCD23 (B) level during the 3 yr immunotherapy.
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Figure 2: Changes of serum specific IgE (A) and sCD23 (B) level during the 3 yr immunotherapy.

Mentions: Fig. 2 shows the changes of serum specific IgE to Hop J pollen extracts and sCD23 levels during 3 yr study period. There were no significant changes in either total (data not shown) or specific IgE antibody levels during the 3-yr of immunotherapy (p>0.05, respectively), however sCD23 level began to decrease during the first year and significantly decreased during next two years. (p=0.003)


Changes of serum cytokines after the long term immunotherapy with Japanese hop pollen extracts.

Ye YM, Lee SK, Kim SH, Nahm DH, Suh CH, Park HS - J. Korean Med. Sci. (2006)

Changes of serum specific IgE (A) and sCD23 (B) level during the 3 yr immunotherapy.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2721987&req=5

Figure 2: Changes of serum specific IgE (A) and sCD23 (B) level during the 3 yr immunotherapy.
Mentions: Fig. 2 shows the changes of serum specific IgE to Hop J pollen extracts and sCD23 levels during 3 yr study period. There were no significant changes in either total (data not shown) or specific IgE antibody levels during the 3-yr of immunotherapy (p>0.05, respectively), however sCD23 level began to decrease during the first year and significantly decreased during next two years. (p=0.003)

Bottom Line: Skin reactivity and airway hyper-responsiveness to methacholine were improved during the study period.Specific IgG1 increased at 1 yr then decreased again at 3 yr, and specific IgG4 levels increased progressively (p<0.05, respectively), whereas total and specific IgE levels showed variable responses with no statistical significance.IL-10, TGF-beta1 and soluble CD23 level began to decrease during first year and then further decreased during next two years with statistical significances. (p<0.05, respectively).

View Article: PubMed Central - PubMed

Affiliation: Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea.

ABSTRACT
Japanese hop (Hop J) pollen has been considered as one of the major causative pollen allergens in the autumn season. We developed a new Hop J immunotherapy extract in collaboration with Allergopharma (Reinbeck, Germany) and investigated immunologic mechanisms during 3 yr immunotherapy. Twenty patients (13 asthma with rhinitis and 7 hay fever) were enrolled from Ajou University Hospital. Sera were collected before, 1 yr, and 3 yr after the immunotherapy. Changes of serum specific IgE, IgG1, and IgG4 levels to Hop J pollen extracts and serum IL-10, IL-12, TGF-beta1 and soluble CD23 levels were monitored by ELISA. Skin reactivity and airway hyper-responsiveness to methacholine were improved during the study period. Specific IgG1 increased at 1 yr then decreased again at 3 yr, and specific IgG4 levels increased progressively (p<0.05, respectively), whereas total and specific IgE levels showed variable responses with no statistical significance. IL-10, TGF-beta1 and soluble CD23 level began to decrease during first year and then further decreased during next two years with statistical significances. (p<0.05, respectively). In conclusion, these findings suggested the favorable effect of long term immunotherapy with Hop J pollen extracts can be explained by lowered IgE affinity and generation of specific IgG4, which may be mediated by IL-10 and TGF-beta1.

Show MeSH
Related in: MedlinePlus