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Efficacy of two triple eradication regimens in children with Helicobacter pylori infection.

Choi J, Jang JY, Kim JS, Park HY, Choe YH, Kim KM - J. Korean Med. Sci. (2006)

Bottom Line: Triple therapy with bismuth subsalicylate, amoxicillin, metronidazole (BAM) or with omeprazole, amoxicillin, clarithromycin (OAC) has been commonly used for the eradication of Helicobacter pylori infection.Overall eradication rates of triple therapy with OAC and BAM were 74% and 85%, respectively, which showed no statistical difference.Our study showed that the triple therapy with BAM was more effective for the first-line eradication of H. pylori infection in Korean children, but has no statistical difference with OAC regimen.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Songpa-Gu, Seoul, Korea.

ABSTRACT
Triple therapy with bismuth subsalicylate, amoxicillin, metronidazole (BAM) or with omeprazole, amoxicillin, clarithromycin (OAC) has been commonly used for the eradication of Helicobacter pylori infection. We compared the efficacy of these triple therapies in children with H. pylori infection. We retrospectively analyzed results in 233 children with H. pylori infection and treated with OAC (n=141) or BAM (n=92). Overall eradication rates of triple therapy with OAC and BAM were 74% and 85%, respectively, which showed no statistical difference. Our study showed that the triple therapy with BAM was more effective for the first-line eradication of H. pylori infection in Korean children, but has no statistical difference with OAC regimen.

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Related in: MedlinePlus

Treatment strategies and outcomes of the study population. OAC, omeprazole+amoxicillin+clarithromycin; BAM, bismuth subsalicylate+amoxicillin+metronidazole; UBT, urea breath test.
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Figure 1: Treatment strategies and outcomes of the study population. OAC, omeprazole+amoxicillin+clarithromycin; BAM, bismuth subsalicylate+amoxicillin+metronidazole; UBT, urea breath test.

Mentions: Of the 92 children treated with the BAM regimen, 78 were UBT negative after treatment. Of the 14 children who failed the BAM regimen, 7 were secondarily treated with the OAC regimen, of whom 6 became UBT negative (Fig. 1).


Efficacy of two triple eradication regimens in children with Helicobacter pylori infection.

Choi J, Jang JY, Kim JS, Park HY, Choe YH, Kim KM - J. Korean Med. Sci. (2006)

Treatment strategies and outcomes of the study population. OAC, omeprazole+amoxicillin+clarithromycin; BAM, bismuth subsalicylate+amoxicillin+metronidazole; UBT, urea breath test.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2721925&req=5

Figure 1: Treatment strategies and outcomes of the study population. OAC, omeprazole+amoxicillin+clarithromycin; BAM, bismuth subsalicylate+amoxicillin+metronidazole; UBT, urea breath test.
Mentions: Of the 92 children treated with the BAM regimen, 78 were UBT negative after treatment. Of the 14 children who failed the BAM regimen, 7 were secondarily treated with the OAC regimen, of whom 6 became UBT negative (Fig. 1).

Bottom Line: Triple therapy with bismuth subsalicylate, amoxicillin, metronidazole (BAM) or with omeprazole, amoxicillin, clarithromycin (OAC) has been commonly used for the eradication of Helicobacter pylori infection.Overall eradication rates of triple therapy with OAC and BAM were 74% and 85%, respectively, which showed no statistical difference.Our study showed that the triple therapy with BAM was more effective for the first-line eradication of H. pylori infection in Korean children, but has no statistical difference with OAC regimen.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Songpa-Gu, Seoul, Korea.

ABSTRACT
Triple therapy with bismuth subsalicylate, amoxicillin, metronidazole (BAM) or with omeprazole, amoxicillin, clarithromycin (OAC) has been commonly used for the eradication of Helicobacter pylori infection. We compared the efficacy of these triple therapies in children with H. pylori infection. We retrospectively analyzed results in 233 children with H. pylori infection and treated with OAC (n=141) or BAM (n=92). Overall eradication rates of triple therapy with OAC and BAM were 74% and 85%, respectively, which showed no statistical difference. Our study showed that the triple therapy with BAM was more effective for the first-line eradication of H. pylori infection in Korean children, but has no statistical difference with OAC regimen.

Show MeSH
Related in: MedlinePlus