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The prevalence and evolution of anemia associated with tuberculosis.

Lee SW, Kang YA, Yoon YS, Um SW, Lee SM, Yoo CG, Kim YW, Han SK, Shim YS, Yim JJ - J. Korean Med. Sci. (2006)

Bottom Line: The medical records of adult patients with TB diagnosed between June 2000 and May 2001 were reviewed.The mean duration of resolution from the initiation of anti-TB treatment was 118.8+/-113.2 days.In conclusion, anemia is a common hematological abnormality in patients with TB and close observation is sufficient for patients with TB-associated anemia, because TB-associated anemia is usually mild and resolves with anti-TB treatment.

View Article: PubMed Central - PubMed

Affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT
Tuberculosis (TB) may produce abnormalities in the peripheral blood, including anemia. However, the evolution of TB-associated anemia with short-term combination anti-TB chemotherapy has not been well elucidated. The aim of this study was to characterize TB-associated anemia by clarifying its prevalence, characteristics, and evolution, through involving large numbers of patients with TB. The medical records of adult patients with TB diagnosed between June 2000 and May 2001 were reviewed. Among 880 patients with TB, 281 (31.9%) had anemia on diagnosis of TB, however, the hemoglobin concentration was less than 10 g/dL in only 45 patients (5.0%). Anemia was more frequently associated with the female and old age. Good treatment response, young age (< or =65 yr-old) and initial high hemoglobin were the predictive factor for resolution of anemia. In 202 patients with anemia (71.9%), anemia was normocytic and normochromic. During or after anti-TB treatment, anemia was resolved in 175 (64.6%) out of 271 patients without iron intake. The mean duration of resolution from the initiation of anti-TB treatment was 118.8+/-113.2 days. In conclusion, anemia is a common hematological abnormality in patients with TB and close observation is sufficient for patients with TB-associated anemia, because TB-associated anemia is usually mild and resolves with anti-TB treatment.

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Prevalence and evolution of anemia in 892 patients with TB. *hemoglobin.
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Figure 1: Prevalence and evolution of anemia in 892 patients with TB. *hemoglobin.

Mentions: Among the other 96 patients with persistent anemia, the hemoglobin concentration increased more than 1 g/dL in 25 patients and was stationary within 1 g/dL from the initial level in the other 71 patients. There were no patients in whom the hemoglobin concentration decreased by more than 1 g/dL. In 63 of the 71 patients with stable hemoglobin levels, the initial hemoglobin concentration was greater than 11.0 g/dL. Seven of the remaining eight patients with persistent anemia, whose hemoglobin concentration was less than 11.0 g/dL, had a poor performance status; poor oral intake, severe parkinsonism, old age (85 yr old), or were bedridden. The remaining patient had endometrial polyps with menorrhagia (Fig. 1).


The prevalence and evolution of anemia associated with tuberculosis.

Lee SW, Kang YA, Yoon YS, Um SW, Lee SM, Yoo CG, Kim YW, Han SK, Shim YS, Yim JJ - J. Korean Med. Sci. (2006)

Prevalence and evolution of anemia in 892 patients with TB. *hemoglobin.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2721923&req=5

Figure 1: Prevalence and evolution of anemia in 892 patients with TB. *hemoglobin.
Mentions: Among the other 96 patients with persistent anemia, the hemoglobin concentration increased more than 1 g/dL in 25 patients and was stationary within 1 g/dL from the initial level in the other 71 patients. There were no patients in whom the hemoglobin concentration decreased by more than 1 g/dL. In 63 of the 71 patients with stable hemoglobin levels, the initial hemoglobin concentration was greater than 11.0 g/dL. Seven of the remaining eight patients with persistent anemia, whose hemoglobin concentration was less than 11.0 g/dL, had a poor performance status; poor oral intake, severe parkinsonism, old age (85 yr old), or were bedridden. The remaining patient had endometrial polyps with menorrhagia (Fig. 1).

Bottom Line: The medical records of adult patients with TB diagnosed between June 2000 and May 2001 were reviewed.The mean duration of resolution from the initiation of anti-TB treatment was 118.8+/-113.2 days.In conclusion, anemia is a common hematological abnormality in patients with TB and close observation is sufficient for patients with TB-associated anemia, because TB-associated anemia is usually mild and resolves with anti-TB treatment.

View Article: PubMed Central - PubMed

Affiliation: Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Korea.

ABSTRACT
Tuberculosis (TB) may produce abnormalities in the peripheral blood, including anemia. However, the evolution of TB-associated anemia with short-term combination anti-TB chemotherapy has not been well elucidated. The aim of this study was to characterize TB-associated anemia by clarifying its prevalence, characteristics, and evolution, through involving large numbers of patients with TB. The medical records of adult patients with TB diagnosed between June 2000 and May 2001 were reviewed. Among 880 patients with TB, 281 (31.9%) had anemia on diagnosis of TB, however, the hemoglobin concentration was less than 10 g/dL in only 45 patients (5.0%). Anemia was more frequently associated with the female and old age. Good treatment response, young age (< or =65 yr-old) and initial high hemoglobin were the predictive factor for resolution of anemia. In 202 patients with anemia (71.9%), anemia was normocytic and normochromic. During or after anti-TB treatment, anemia was resolved in 175 (64.6%) out of 271 patients without iron intake. The mean duration of resolution from the initiation of anti-TB treatment was 118.8+/-113.2 days. In conclusion, anemia is a common hematological abnormality in patients with TB and close observation is sufficient for patients with TB-associated anemia, because TB-associated anemia is usually mild and resolves with anti-TB treatment.

Show MeSH
Related in: MedlinePlus