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Comparison of allergic indices in monosensitized and polysensitized patients with childhood asthma.

Kim KW, Kim EA, Kwon BC, Kim ES, Song TW, Sohn MH, Kim KE - J. Korean Med. Sci. (2006)

Bottom Line: Measurements included symptom scores, eosinophil counts, skin prick tests, serum total and specific IgE levels, and IL-10 levels, and were used to compare allergic indices between the two groups.Symptom scores and total IgE levels were significantly higher in the polysensitized group than those in the monosensitized group (p<0.05).The levels of skin test response decreased significantly in both groups following immunotherapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics and Institute of Allergy, Biomolecule Secretion Research Center, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT
Monosensitization differs both immunologically and clinically from polysensitization, and specific immunotherapy is more effective in patients sensitized only to a single pollen than in multiple-pollen sensitized patients. To further examine the differences between monosensitized and polysensitized allergies, allergic indices were examined in 68 monosensitized and 62 polysensitized patients with childhood asthma. Measurements included symptom scores, eosinophil counts, skin prick tests, serum total and specific IgE levels, and IL-10 levels, and were used to compare allergic indices between the two groups. Patients were followed for 18 months following immunotherapy to examine the effectiveness of the treatment. Symptom scores and total IgE levels were significantly higher in the polysensitized group than those in the monosensitized group (p<0.05). The levels of skin test response decreased significantly in both groups following immunotherapy. In the monosensitized group, symptom scores and specific IgE levels were significantly reduced after immunotherapy (p<0.05). In the polysensitized group, symptom scores were reduced after immunotherapy (p<0.05), but the degree of reduction was less than that of the monosensitized group (p<0.05). Moreover, in the polysensitized group, specific IgE levels after immunotherapy did not differ from that before immunotherapy. Serum IL-10 levels were not significantly increased after immunotherapy in either group. In conclusion, polysensitized patients tend to show higher allergic indices and immunotherapy might be less effective for these patients.

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The level of IgE specific to house dust mite (D. farinae) decreases significantly after immunotherapy in the monosensitized group (p<0.05), but not in the polysensitized group. Error bars represent standard deviation. NS, not significant.
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Figure 2: The level of IgE specific to house dust mite (D. farinae) decreases significantly after immunotherapy in the monosensitized group (p<0.05), but not in the polysensitized group. Error bars represent standard deviation. NS, not significant.

Mentions: The results of tests conducted before and after immunotherapy showed that changes in the total serum IgE levels, eosinophil counts and serum IL-10 levels were not statistically different between the monosensitized group and polysensitized group (Table 2). In the monosensitized group, symptom scores were decreased from 5.0±0.1 before immunotherapy to 1.7±0.1 after immunotherapy (p<0.05) (Fig. 1). The levels of house dust mite-specific IgE were decreased significantly from 97.3±34.2 IU/mL before immunotherapy to 59.2±21.9 IU/mL after immunotherapy (p<0.05) (Fig. 2). The levels of skin test response were also decreased significantly after immunotherapy (p<0.05) (Table 2). In the polysensitized group, symptom scores were decreased from 5.3±0.1 before immunotherapy to 2.4±0.1 after immunotherapy (p<0.05), less of a decrease than the monosensitized group (p<0.05). The levels of house dust mite-specific IgE actually increased from 65.8±21.6 IU/mL before immunotherapy to 73.2±40.2 IU/mL after immunotherapy (Fig. 2). However, the degree of skin test response was decreased significantly after immunotherapy (p<0.05) (Table 2).


Comparison of allergic indices in monosensitized and polysensitized patients with childhood asthma.

Kim KW, Kim EA, Kwon BC, Kim ES, Song TW, Sohn MH, Kim KE - J. Korean Med. Sci. (2006)

The level of IgE specific to house dust mite (D. farinae) decreases significantly after immunotherapy in the monosensitized group (p<0.05), but not in the polysensitized group. Error bars represent standard deviation. NS, not significant.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2721920&req=5

Figure 2: The level of IgE specific to house dust mite (D. farinae) decreases significantly after immunotherapy in the monosensitized group (p<0.05), but not in the polysensitized group. Error bars represent standard deviation. NS, not significant.
Mentions: The results of tests conducted before and after immunotherapy showed that changes in the total serum IgE levels, eosinophil counts and serum IL-10 levels were not statistically different between the monosensitized group and polysensitized group (Table 2). In the monosensitized group, symptom scores were decreased from 5.0±0.1 before immunotherapy to 1.7±0.1 after immunotherapy (p<0.05) (Fig. 1). The levels of house dust mite-specific IgE were decreased significantly from 97.3±34.2 IU/mL before immunotherapy to 59.2±21.9 IU/mL after immunotherapy (p<0.05) (Fig. 2). The levels of skin test response were also decreased significantly after immunotherapy (p<0.05) (Table 2). In the polysensitized group, symptom scores were decreased from 5.3±0.1 before immunotherapy to 2.4±0.1 after immunotherapy (p<0.05), less of a decrease than the monosensitized group (p<0.05). The levels of house dust mite-specific IgE actually increased from 65.8±21.6 IU/mL before immunotherapy to 73.2±40.2 IU/mL after immunotherapy (Fig. 2). However, the degree of skin test response was decreased significantly after immunotherapy (p<0.05) (Table 2).

Bottom Line: Measurements included symptom scores, eosinophil counts, skin prick tests, serum total and specific IgE levels, and IL-10 levels, and were used to compare allergic indices between the two groups.Symptom scores and total IgE levels were significantly higher in the polysensitized group than those in the monosensitized group (p<0.05).The levels of skin test response decreased significantly in both groups following immunotherapy.

View Article: PubMed Central - PubMed

Affiliation: Department of Pediatrics and Institute of Allergy, Biomolecule Secretion Research Center, Yonsei University College of Medicine, Seoul, Korea.

ABSTRACT
Monosensitization differs both immunologically and clinically from polysensitization, and specific immunotherapy is more effective in patients sensitized only to a single pollen than in multiple-pollen sensitized patients. To further examine the differences between monosensitized and polysensitized allergies, allergic indices were examined in 68 monosensitized and 62 polysensitized patients with childhood asthma. Measurements included symptom scores, eosinophil counts, skin prick tests, serum total and specific IgE levels, and IL-10 levels, and were used to compare allergic indices between the two groups. Patients were followed for 18 months following immunotherapy to examine the effectiveness of the treatment. Symptom scores and total IgE levels were significantly higher in the polysensitized group than those in the monosensitized group (p<0.05). The levels of skin test response decreased significantly in both groups following immunotherapy. In the monosensitized group, symptom scores and specific IgE levels were significantly reduced after immunotherapy (p<0.05). In the polysensitized group, symptom scores were reduced after immunotherapy (p<0.05), but the degree of reduction was less than that of the monosensitized group (p<0.05). Moreover, in the polysensitized group, specific IgE levels after immunotherapy did not differ from that before immunotherapy. Serum IL-10 levels were not significantly increased after immunotherapy in either group. In conclusion, polysensitized patients tend to show higher allergic indices and immunotherapy might be less effective for these patients.

Show MeSH
Related in: MedlinePlus