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Lipid profile in oral submucous fibrosis.

Mehrotra R, Pandya S, Chaudhary AK, Singh HP, Jaiswal RK, Singh M, Gupta SC, Singh M - Lipids Health Dis (2009)

Bottom Line: A significant decrease in plasma total cholesterol, HDLC and Apo-A1 was observed in patients with OSMF as compared to the controls.Thus an inverse relationship between plasma lipid levels and patients was found in OSMF.The lower levels of plasma cholesterol and other lipid constituents in patients might be due to their increased utilization.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, M.L.N. Medical College, Allahabad, India. rm8509@gmail.com

ABSTRACT

Background: Changes in lipid profile have long been associated with malignancies as lipids play a key role in maintenance of cell integrity. This study evaluated the alterations in extended lipid profile in untreated patients of oral submucous fibrosis (OSMF) and studied the correlation between lipid levels with tobacco consumption.

Materials and methods: In this hospital-based study, 65 clinically diagnosed and histopathologically proven patients of OSMF and 42 age and sex matched controls were studied. In these samples serum lipids including: (i) Total cholesterol, (ii) LDL cholesterol (LDLC), (iii) HDL cholesterol (HDLC) (iv) VLDL cholesterol (VLDLC) (v) triglycerides (vi) Apo-A1 (viii) Apo-B and (viii) LPa were analyzed.

Results: A significant decrease in plasma total cholesterol, HDLC and Apo-A1 was observed in patients with OSMF as compared to the controls. Thus an inverse relationship between plasma lipid levels and patients was found in OSMF.

Conclusion: The lower levels of plasma cholesterol and other lipid constituents in patients might be due to their increased utilization. The findings strongly warrant an in-depth study of alterations in plasma lipid profile in patients with oral precancerous conditions.

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Related in: MedlinePlus

Showing clinical picture (blanching and fibrosis) in oral submucous fibrosis.
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Figure 1: Showing clinical picture (blanching and fibrosis) in oral submucous fibrosis.

Mentions: Sixty five cases of OSMF were studied. Maximum patients (30; 46.2%) were in their second decade (21–30 yrs) of life with a male predominance. According to the addiction habits, 26 (40%) consumed paan masala or dohra (a locally available combination of slaked lime and areca nut), 30.8% patients were addicted to betel quid with tobacco while 16 (24.6%) were smokers. Only 3 (6.6%) did not have any habit. 12 (18.5%) patients had a burning sensation in mouth, 16 (24.6%) had ulceration in the oral cavity, 15 (23%) had excessive salivation while 22 (33.7%) had difficulty in opening the mouth (trismus) (Figure 1). On clinical grading of trismus, 5 patients were found to have grade I (>3 cm), 34 had grade II (2–3 cm), and 26 had grade III (<2 cm) (Table 1). 28 patients consumed paan masala and betel quid with tobacco for 11–15 years (1–10 times/day), while 17 patients were addicted for 6–10 years (11–20 times/day) (Table 2).


Lipid profile in oral submucous fibrosis.

Mehrotra R, Pandya S, Chaudhary AK, Singh HP, Jaiswal RK, Singh M, Gupta SC, Singh M - Lipids Health Dis (2009)

Showing clinical picture (blanching and fibrosis) in oral submucous fibrosis.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2721834&req=5

Figure 1: Showing clinical picture (blanching and fibrosis) in oral submucous fibrosis.
Mentions: Sixty five cases of OSMF were studied. Maximum patients (30; 46.2%) were in their second decade (21–30 yrs) of life with a male predominance. According to the addiction habits, 26 (40%) consumed paan masala or dohra (a locally available combination of slaked lime and areca nut), 30.8% patients were addicted to betel quid with tobacco while 16 (24.6%) were smokers. Only 3 (6.6%) did not have any habit. 12 (18.5%) patients had a burning sensation in mouth, 16 (24.6%) had ulceration in the oral cavity, 15 (23%) had excessive salivation while 22 (33.7%) had difficulty in opening the mouth (trismus) (Figure 1). On clinical grading of trismus, 5 patients were found to have grade I (>3 cm), 34 had grade II (2–3 cm), and 26 had grade III (<2 cm) (Table 1). 28 patients consumed paan masala and betel quid with tobacco for 11–15 years (1–10 times/day), while 17 patients were addicted for 6–10 years (11–20 times/day) (Table 2).

Bottom Line: A significant decrease in plasma total cholesterol, HDLC and Apo-A1 was observed in patients with OSMF as compared to the controls.Thus an inverse relationship between plasma lipid levels and patients was found in OSMF.The lower levels of plasma cholesterol and other lipid constituents in patients might be due to their increased utilization.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Pathology, M.L.N. Medical College, Allahabad, India. rm8509@gmail.com

ABSTRACT

Background: Changes in lipid profile have long been associated with malignancies as lipids play a key role in maintenance of cell integrity. This study evaluated the alterations in extended lipid profile in untreated patients of oral submucous fibrosis (OSMF) and studied the correlation between lipid levels with tobacco consumption.

Materials and methods: In this hospital-based study, 65 clinically diagnosed and histopathologically proven patients of OSMF and 42 age and sex matched controls were studied. In these samples serum lipids including: (i) Total cholesterol, (ii) LDL cholesterol (LDLC), (iii) HDL cholesterol (HDLC) (iv) VLDL cholesterol (VLDLC) (v) triglycerides (vi) Apo-A1 (viii) Apo-B and (viii) LPa were analyzed.

Results: A significant decrease in plasma total cholesterol, HDLC and Apo-A1 was observed in patients with OSMF as compared to the controls. Thus an inverse relationship between plasma lipid levels and patients was found in OSMF.

Conclusion: The lower levels of plasma cholesterol and other lipid constituents in patients might be due to their increased utilization. The findings strongly warrant an in-depth study of alterations in plasma lipid profile in patients with oral precancerous conditions.

Show MeSH
Related in: MedlinePlus