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Measurement of pharyngeal sensory cortical processing: technique and physiologic implications.

Teismann IK, Steinstraeter O, Warnecke T, Ringelstein EB, Pantev C, Dziewas R - BMC Neurosci (2009)

Bottom Line: The results are in keeping with previous findings showing bihemispheric involvement in the complex task of sensory pharyngeal processing.They might also explain changes in deglutition after hemispheric strokes.The ipsilaterally lateralized processing is surprising and needs further investigation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute for Biomagnetism and Biosignalanalysis, University of Muenster, Malmedyweg 15, 48149 Muenster, Germany. i.teismann@uni-muenster.de

ABSTRACT

Background: Dysphagia is a major complication of different diseases affecting both the central and peripheral nervous system. Pharyngeal sensory impairment is one of the main features of neurogenic dysphagia. Therefore an objective technique to examine the cortical processing of pharyngeal sensory input would be a helpful diagnostic tool in this context. We developed a simple paradigm to perform pneumatic stimulation to both sides of the pharyngeal wall. Whole-head MEG was employed to study changes in cortical activation during this pharyngeal stimulation in nine healthy subjects. Data were analyzed by means of synthetic aperture magnetometry (SAM) and the group analysis of individual SAM data was performed using a permutation test.

Results: Our results revealed bilateral activation of the caudolateral primary somatosensory cortex following sensory pharyngeal stimulation with a slight lateralization to the side of stimulation.

Conclusion: The method introduced here is simple and easy to perform and might be applicable in the clinical setting. The results are in keeping with previous findings showing bihemispheric involvement in the complex task of sensory pharyngeal processing. They might also explain changes in deglutition after hemispheric strokes. The ipsilaterally lateralized processing is surprising and needs further investigation.

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Event related desynchronization. Significant activation in group analysis is shown (p < 0.05). Changes in the beta-frequency-band during pneumatic pharyngeal activation compared to the resting stage. a) ERD evoked by pneumatic stimulation to the left side of the pharyngeal wall. Stronger and broader activation is found in the temporal lobe of the left hemisphere. b) ERD evoked by pneumatic stimulation of the right side of the pharyngeal wall. Here a right hemispheric lateralization of temporal activation can be seen. The color bar represents the t-value.
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Figure 2: Event related desynchronization. Significant activation in group analysis is shown (p < 0.05). Changes in the beta-frequency-band during pneumatic pharyngeal activation compared to the resting stage. a) ERD evoked by pneumatic stimulation to the left side of the pharyngeal wall. Stronger and broader activation is found in the temporal lobe of the left hemisphere. b) ERD evoked by pneumatic stimulation of the right side of the pharyngeal wall. Here a right hemispheric lateralization of temporal activation can be seen. The color bar represents the t-value.

Mentions: SAM group analysis resulted in significant beta ERD for both stimulated sides (p < 0.05). Again maximum ERD were located bilaterally within the caudolateral primary somatosensory cortex, corresponding to Brodmann areas (BA) 1, 2, and 3 but also spread into the motor cortex and secondary somatosensory areas (BA 4, 6, 5, and 40) [see table 1 and figure 2]. No significant activation in group analysis was observed in any other cortical area or in the alpha frequency range.


Measurement of pharyngeal sensory cortical processing: technique and physiologic implications.

Teismann IK, Steinstraeter O, Warnecke T, Ringelstein EB, Pantev C, Dziewas R - BMC Neurosci (2009)

Event related desynchronization. Significant activation in group analysis is shown (p < 0.05). Changes in the beta-frequency-band during pneumatic pharyngeal activation compared to the resting stage. a) ERD evoked by pneumatic stimulation to the left side of the pharyngeal wall. Stronger and broader activation is found in the temporal lobe of the left hemisphere. b) ERD evoked by pneumatic stimulation of the right side of the pharyngeal wall. Here a right hemispheric lateralization of temporal activation can be seen. The color bar represents the t-value.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2719647&req=5

Figure 2: Event related desynchronization. Significant activation in group analysis is shown (p < 0.05). Changes in the beta-frequency-band during pneumatic pharyngeal activation compared to the resting stage. a) ERD evoked by pneumatic stimulation to the left side of the pharyngeal wall. Stronger and broader activation is found in the temporal lobe of the left hemisphere. b) ERD evoked by pneumatic stimulation of the right side of the pharyngeal wall. Here a right hemispheric lateralization of temporal activation can be seen. The color bar represents the t-value.
Mentions: SAM group analysis resulted in significant beta ERD for both stimulated sides (p < 0.05). Again maximum ERD were located bilaterally within the caudolateral primary somatosensory cortex, corresponding to Brodmann areas (BA) 1, 2, and 3 but also spread into the motor cortex and secondary somatosensory areas (BA 4, 6, 5, and 40) [see table 1 and figure 2]. No significant activation in group analysis was observed in any other cortical area or in the alpha frequency range.

Bottom Line: The results are in keeping with previous findings showing bihemispheric involvement in the complex task of sensory pharyngeal processing.They might also explain changes in deglutition after hemispheric strokes.The ipsilaterally lateralized processing is surprising and needs further investigation.

View Article: PubMed Central - HTML - PubMed

Affiliation: Institute for Biomagnetism and Biosignalanalysis, University of Muenster, Malmedyweg 15, 48149 Muenster, Germany. i.teismann@uni-muenster.de

ABSTRACT

Background: Dysphagia is a major complication of different diseases affecting both the central and peripheral nervous system. Pharyngeal sensory impairment is one of the main features of neurogenic dysphagia. Therefore an objective technique to examine the cortical processing of pharyngeal sensory input would be a helpful diagnostic tool in this context. We developed a simple paradigm to perform pneumatic stimulation to both sides of the pharyngeal wall. Whole-head MEG was employed to study changes in cortical activation during this pharyngeal stimulation in nine healthy subjects. Data were analyzed by means of synthetic aperture magnetometry (SAM) and the group analysis of individual SAM data was performed using a permutation test.

Results: Our results revealed bilateral activation of the caudolateral primary somatosensory cortex following sensory pharyngeal stimulation with a slight lateralization to the side of stimulation.

Conclusion: The method introduced here is simple and easy to perform and might be applicable in the clinical setting. The results are in keeping with previous findings showing bihemispheric involvement in the complex task of sensory pharyngeal processing. They might also explain changes in deglutition after hemispheric strokes. The ipsilaterally lateralized processing is surprising and needs further investigation.

Show MeSH
Related in: MedlinePlus