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Activation of the pre-supplementary motor area but not inferior prefrontal cortex in association with short stop signal reaction time--an intra-subject analysis.

Chao HH, Luo X, Chang JL, Li CS - BMC Neurosci (2009)

Bottom Line: The pre-supplementary motor area (preSMA), which shows greater activity in individuals with short as compared to those with long SSRT, plays a role in mediating response inhibition.In contrast, the right inferior prefrontal cortex (rIFC) showed greater activity during stop success as compared to stop error.By comparing regional brain activation between the two sessions, we confirmed greater preSMA but not rIFC activity during short as compared to long SSRT session within individuals.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA. herta.chao@yale.edu

ABSTRACT

Background: Our previous work described the neural processes of motor response inhibition during a stop signal task (SST). Employing the race model, we computed the stop signal reaction time (SSRT) to index individuals' ability in inhibitory control. The pre-supplementary motor area (preSMA), which shows greater activity in individuals with short as compared to those with long SSRT, plays a role in mediating response inhibition. In contrast, the right inferior prefrontal cortex (rIFC) showed greater activity during stop success as compared to stop error. Here we further pursued this functional differentiation of preSMA and rIFC on the basis of an intra-subject approach.

Results: Of 65 subjects who participated in four sessions of the SST, we identified 30 individuals who showed a difference in SSRT but were identical in other aspects of stop signal performance between the first ("early") and last two ("late") sessions. By comparing regional brain activation between the two sessions, we confirmed greater preSMA but not rIFC activity during short as compared to long SSRT session within individuals. Furthermore, putamen, anterior cerebellum and middle/posterior cingulate cortex also showed greater activity in association with short SSRT.

Conclusion: These results are consistent with a role of medial prefrontal cortex in controlled action and inferior frontal cortex in orienting attention. We discussed these findings with respect to the process of attentional monitoring and inhibitory motor control during stop signal inhibition.

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Effect sizes of stop signal inhibition in association with stop signal reaction time (SSRT): (a) Pre-supplementary motor area (preSMA) and effect size (mean ± standard deviation) of stop success (SS) > stop error (SE) for short and long SSRT sessions and subject groups; group 1 = long SSRT during "early" sessions; group 2 = short SSRT during "early" sessions; (b) Right inferior prefrontal cortex (rIFC) and effect size (mean ± standard deviation) of SS > stop error SE for short and long SSRT sessions and subject groups.
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Figure 2: Effect sizes of stop signal inhibition in association with stop signal reaction time (SSRT): (a) Pre-supplementary motor area (preSMA) and effect size (mean ± standard deviation) of stop success (SS) > stop error (SE) for short and long SSRT sessions and subject groups; group 1 = long SSRT during "early" sessions; group 2 = short SSRT during "early" sessions; (b) Right inferior prefrontal cortex (rIFC) and effect size (mean ± standard deviation) of SS > stop error SE for short and long SSRT sessions and subject groups.

Mentions: To test our hypothesis, we compared short and long SSRT sessions with a paired sample t test with small volume correction for the preSMA and rIFC masks. The results showed greater activity in the preSMA in the short as compared to long SSRT sessions (p < 0.020, corrected for family-wise error of multiple comparison, x = 0, y = 40, z = 56; voxel Z = 2.96). In contrast, neither rIFC mask differentiated between short and long SSRT sessions at a threshold of p = 0.05, uncorrected. Likewise, because of potential "order" effect, we compared the effect size of stop success > stop error each for preSMA and rIFC masks on the basis of a 2-factor repeated measure ANOVA with SSRT (short vs. long) session as a within-subject variable and group (early vs. late session with short SSRT) as a between-subject variable. The results showed greater activity in the preSMA (F1,28 = 4.843, p = 0.030) but not in the rIFC mask (F1,28 = 0.808 and 0.916, p = 0.376 and 0.371) in the short as compared to long SSRT session (within-subject factor). Figure 2 illustrated these results for preSMA and one rIFC mask.


Activation of the pre-supplementary motor area but not inferior prefrontal cortex in association with short stop signal reaction time--an intra-subject analysis.

Chao HH, Luo X, Chang JL, Li CS - BMC Neurosci (2009)

Effect sizes of stop signal inhibition in association with stop signal reaction time (SSRT): (a) Pre-supplementary motor area (preSMA) and effect size (mean ± standard deviation) of stop success (SS) > stop error (SE) for short and long SSRT sessions and subject groups; group 1 = long SSRT during "early" sessions; group 2 = short SSRT during "early" sessions; (b) Right inferior prefrontal cortex (rIFC) and effect size (mean ± standard deviation) of SS > stop error SE for short and long SSRT sessions and subject groups.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2719646&req=5

Figure 2: Effect sizes of stop signal inhibition in association with stop signal reaction time (SSRT): (a) Pre-supplementary motor area (preSMA) and effect size (mean ± standard deviation) of stop success (SS) > stop error (SE) for short and long SSRT sessions and subject groups; group 1 = long SSRT during "early" sessions; group 2 = short SSRT during "early" sessions; (b) Right inferior prefrontal cortex (rIFC) and effect size (mean ± standard deviation) of SS > stop error SE for short and long SSRT sessions and subject groups.
Mentions: To test our hypothesis, we compared short and long SSRT sessions with a paired sample t test with small volume correction for the preSMA and rIFC masks. The results showed greater activity in the preSMA in the short as compared to long SSRT sessions (p < 0.020, corrected for family-wise error of multiple comparison, x = 0, y = 40, z = 56; voxel Z = 2.96). In contrast, neither rIFC mask differentiated between short and long SSRT sessions at a threshold of p = 0.05, uncorrected. Likewise, because of potential "order" effect, we compared the effect size of stop success > stop error each for preSMA and rIFC masks on the basis of a 2-factor repeated measure ANOVA with SSRT (short vs. long) session as a within-subject variable and group (early vs. late session with short SSRT) as a between-subject variable. The results showed greater activity in the preSMA (F1,28 = 4.843, p = 0.030) but not in the rIFC mask (F1,28 = 0.808 and 0.916, p = 0.376 and 0.371) in the short as compared to long SSRT session (within-subject factor). Figure 2 illustrated these results for preSMA and one rIFC mask.

Bottom Line: The pre-supplementary motor area (preSMA), which shows greater activity in individuals with short as compared to those with long SSRT, plays a role in mediating response inhibition.In contrast, the right inferior prefrontal cortex (rIFC) showed greater activity during stop success as compared to stop error.By comparing regional brain activation between the two sessions, we confirmed greater preSMA but not rIFC activity during short as compared to long SSRT session within individuals.

View Article: PubMed Central - HTML - PubMed

Affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA. herta.chao@yale.edu

ABSTRACT

Background: Our previous work described the neural processes of motor response inhibition during a stop signal task (SST). Employing the race model, we computed the stop signal reaction time (SSRT) to index individuals' ability in inhibitory control. The pre-supplementary motor area (preSMA), which shows greater activity in individuals with short as compared to those with long SSRT, plays a role in mediating response inhibition. In contrast, the right inferior prefrontal cortex (rIFC) showed greater activity during stop success as compared to stop error. Here we further pursued this functional differentiation of preSMA and rIFC on the basis of an intra-subject approach.

Results: Of 65 subjects who participated in four sessions of the SST, we identified 30 individuals who showed a difference in SSRT but were identical in other aspects of stop signal performance between the first ("early") and last two ("late") sessions. By comparing regional brain activation between the two sessions, we confirmed greater preSMA but not rIFC activity during short as compared to long SSRT session within individuals. Furthermore, putamen, anterior cerebellum and middle/posterior cingulate cortex also showed greater activity in association with short SSRT.

Conclusion: These results are consistent with a role of medial prefrontal cortex in controlled action and inferior frontal cortex in orienting attention. We discussed these findings with respect to the process of attentional monitoring and inhibitory motor control during stop signal inhibition.

Show MeSH