Limits...
Influence of lactate dehydrogenase and cyclosporine A level on the incidence of acute graft-versus-host disease after allogeneic stem cell transplantation.

Song MK, Chung JS, Seol YM, Kwon BR, Shin HJ, Choi YJ, Cho GJ - J. Korean Med. Sci. (2009)

Bottom Line: An elevated serum lactate dehydrogenase (LDH) level has been reported to be an adverse predictor of outcome in stem cell transplantation (SCT) for acute myeloid leukemia.Univariate analysis showed that two factors (the serum CsA level at the third week after SCT and the LDH level at the third week after SCT) were significantly associated with the incidence of aGVHD among several variables (age, sex, stem cell source, cell dose, C-reactive protein, absolute lymphocyte count, conditioning regimens, and time to engraftment).We conclude that a high CsA level and low LDH level might predict a low cumulative incidence of aGVHD after allogeneic transplantation from a matched sibling donor.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Medical Research Institute, Pusan National University Hospital, Busan, Korea.

ABSTRACT
Previous reports have suggested that a high serum cyclosporine A (CsA) level could result in a lower incidence of acute-graft-versus-host disease (aGVHD). An elevated serum lactate dehydrogenase (LDH) level has been reported to be an adverse predictor of outcome in stem cell transplantation (SCT) for acute myeloid leukemia. In this study, we retrospectively analyzed the records of 24 patients who received allogeneic SCT from an HLA-matched sibling donor for acute and chronic myelogenous leukemia. Univariate analysis showed that two factors (the serum CsA level at the third week after SCT and the LDH level at the third week after SCT) were significantly associated with the incidence of aGVHD among several variables (age, sex, stem cell source, cell dose, C-reactive protein, absolute lymphocyte count, conditioning regimens, and time to engraftment). A higher serum level of CsA and lower serum LDH level at the third week after SCT were associated with a lower incidence of aGVHD (P=0.015, 0.030). In multivariate analysis, the serum CsA level (hazard ratio [HR], 0.12; 95% confidence interval [CI], 0.022-0.652, P=0.0014) and serum LDH level (HR, 6.59; 95% CI, 1.197-36.316, P=0.030) at the third week after SCT were found to be independent factors that were significantly associated with the development of aGVHD. We conclude that a high CsA level and low LDH level might predict a low cumulative incidence of aGVHD after allogeneic transplantation from a matched sibling donor.

Show MeSH

Related in: MedlinePlus

The cumulative incidence of aGVHD of four groups (HCsA+LLDH, HCsA+HLDH, LCsA+LLDH, and LCsA+HLDH group) at the third week after transplantation. The HCsA+LLDH group showed significantly better results than the other groups (P=0.0016).aGVHD, acute graft-versus-host disease; HCsA, higher cyclosporine A; LCsA, lower cyclosporine A; HLDH, higher lactate dehydrogenase; LCsA, lower cyclosporine A.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
getmorefigures.php?uid=PMC2719215&req=5

Figure 3: The cumulative incidence of aGVHD of four groups (HCsA+LLDH, HCsA+HLDH, LCsA+LLDH, and LCsA+HLDH group) at the third week after transplantation. The HCsA+LLDH group showed significantly better results than the other groups (P=0.0016).aGVHD, acute graft-versus-host disease; HCsA, higher cyclosporine A; LCsA, lower cyclosporine A; HLDH, higher lactate dehydrogenase; LCsA, lower cyclosporine A.

Mentions: These findings prompted us to measure the predictive value of the combination of these two factors (CsA and LDH) for the cumulative incidence of aGVHD above grade II. The lowest incidence of aGVHD was observed in the HCsA+LLDH group, and the incidence of aGVHD was lower in the HCsA+HLDH group than in the LCsA+LLDH group. The highest incidence of aGVHD was observed in the LCsA+HLDH group (P=0.0016, Fig. 3).


Influence of lactate dehydrogenase and cyclosporine A level on the incidence of acute graft-versus-host disease after allogeneic stem cell transplantation.

Song MK, Chung JS, Seol YM, Kwon BR, Shin HJ, Choi YJ, Cho GJ - J. Korean Med. Sci. (2009)

The cumulative incidence of aGVHD of four groups (HCsA+LLDH, HCsA+HLDH, LCsA+LLDH, and LCsA+HLDH group) at the third week after transplantation. The HCsA+LLDH group showed significantly better results than the other groups (P=0.0016).aGVHD, acute graft-versus-host disease; HCsA, higher cyclosporine A; LCsA, lower cyclosporine A; HLDH, higher lactate dehydrogenase; LCsA, lower cyclosporine A.
© Copyright Policy - open-access
Related In: Results  -  Collection

License
Show All Figures
getmorefigures.php?uid=PMC2719215&req=5

Figure 3: The cumulative incidence of aGVHD of four groups (HCsA+LLDH, HCsA+HLDH, LCsA+LLDH, and LCsA+HLDH group) at the third week after transplantation. The HCsA+LLDH group showed significantly better results than the other groups (P=0.0016).aGVHD, acute graft-versus-host disease; HCsA, higher cyclosporine A; LCsA, lower cyclosporine A; HLDH, higher lactate dehydrogenase; LCsA, lower cyclosporine A.
Mentions: These findings prompted us to measure the predictive value of the combination of these two factors (CsA and LDH) for the cumulative incidence of aGVHD above grade II. The lowest incidence of aGVHD was observed in the HCsA+LLDH group, and the incidence of aGVHD was lower in the HCsA+HLDH group than in the LCsA+LLDH group. The highest incidence of aGVHD was observed in the LCsA+HLDH group (P=0.0016, Fig. 3).

Bottom Line: An elevated serum lactate dehydrogenase (LDH) level has been reported to be an adverse predictor of outcome in stem cell transplantation (SCT) for acute myeloid leukemia.Univariate analysis showed that two factors (the serum CsA level at the third week after SCT and the LDH level at the third week after SCT) were significantly associated with the incidence of aGVHD among several variables (age, sex, stem cell source, cell dose, C-reactive protein, absolute lymphocyte count, conditioning regimens, and time to engraftment).We conclude that a high CsA level and low LDH level might predict a low cumulative incidence of aGVHD after allogeneic transplantation from a matched sibling donor.

View Article: PubMed Central - PubMed

Affiliation: Department of Internal Medicine, Medical Research Institute, Pusan National University Hospital, Busan, Korea.

ABSTRACT
Previous reports have suggested that a high serum cyclosporine A (CsA) level could result in a lower incidence of acute-graft-versus-host disease (aGVHD). An elevated serum lactate dehydrogenase (LDH) level has been reported to be an adverse predictor of outcome in stem cell transplantation (SCT) for acute myeloid leukemia. In this study, we retrospectively analyzed the records of 24 patients who received allogeneic SCT from an HLA-matched sibling donor for acute and chronic myelogenous leukemia. Univariate analysis showed that two factors (the serum CsA level at the third week after SCT and the LDH level at the third week after SCT) were significantly associated with the incidence of aGVHD among several variables (age, sex, stem cell source, cell dose, C-reactive protein, absolute lymphocyte count, conditioning regimens, and time to engraftment). A higher serum level of CsA and lower serum LDH level at the third week after SCT were associated with a lower incidence of aGVHD (P=0.015, 0.030). In multivariate analysis, the serum CsA level (hazard ratio [HR], 0.12; 95% confidence interval [CI], 0.022-0.652, P=0.0014) and serum LDH level (HR, 6.59; 95% CI, 1.197-36.316, P=0.030) at the third week after SCT were found to be independent factors that were significantly associated with the development of aGVHD. We conclude that a high CsA level and low LDH level might predict a low cumulative incidence of aGVHD after allogeneic transplantation from a matched sibling donor.

Show MeSH
Related in: MedlinePlus